Preparation of multiwall polymeric microcapsules

• US 4,861,627 A
• Filed: 05/01/1987
• Issued: 08/29/1989
• Est. Priority Date: 05/01/1987
• Status: Expired due to Term

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Langer, Robert S., Mathiowitz, Edith
• Primary Examiner(s): Lovering, Richard D.
• Application Number:
  US07/045,840
• Time in Patent Office: 851 Days
• Field of Search: 264/4.3, 264/4.32, 264/4.6, 427/213.31, 427/213.36, 424/462, 424/497, 514/963
• US Class Current: 427/213.31
• CPC Class Codes: A61K 9/1694 resulting in granules or microspheres of the matrix type containing more than 5% of excipient
• CPC Class Codes: A61K 9/5089 Processes
• CPC Class Codes: Y10T 428/2987 Addition polymer from unsaturated monomers only
• CPC Class Codes: Y10T 428/2989 Microcapsule with solid core [includes liposome]

Abstract

A single step method for preparation of multi-layer polymeric delivery systems. Any two or three different degradable or non-degradable polymers which are not soluble in each other at a particular concentration, as dictated by their phase diagram, can be used. The multi-layer microcapsules produced by the method are distinguished by extremely uniform dimensioned layers of polymer and actual incorporation of the substance to be delivered into the polymer layers.

In the preferred embodiment of the method, two polymers are dissolved in a volatile organic solvent, the substance to be encapsulated is dispersed or dissolved in the polymer solution, the mixture is suspended in an aqueous solution and stirred, and the solvent is slowly evaporated, creating microspheres with an inner core formed by one polymer and an outer layer formed by the second polymer. In another embodiment one polymer may be formed within a layer of the other polymer by increasing the rate of evaporation of the volatile solvent.

Claims

1. A method for forming multi-layered polymeric microcapsules comprising:

selecting first and second polymers, wherein the polymers are selected from the group consisting of polyanhydrides, polyorthoesters, polylactic acid, polystyrene, polyamides, ethylene vinyl acetate, polybutadiene, polyurethanes, and copolymers and combinations thereof, to form microcapsules;

selecting a substance to be incorporated into said microcapsules;

dissolving said polymers in a volatile solvent;

adding the substance to the polymer solution;

mixing the polymer and substance solution;

suspending the polymer substance mixture in a nonsolvent wherein said polymers separate into distinct phases; and

evaporating the volatile solvent to form microcapsules having at least one distinct polymer layer around a polymer core.

2. The method of claim 1 wherein the polymers are selected from the group consisting of polyanhydrides, polyorthoesters, polylactic acid, polystyrene, polyamides, ethylene vinyl acetate, polybutadiene, polyurethanes, and copolymers and combinations thereof, wherein the polymers separate on the basis of differences in molecular weight.

3. The method of claim 1 wherein the volatile solvent is an organic solvent.

4. The method of claim 1 wherein the first polymer is dissolved in a first solvent and the second polymer is dissolved in a second solvent prior to combining the polymers.

5. The method of claim 4 wherein a first substance to be incorporated is added to the first polymer solution.

6. The method of claim 5 wherein a second substance is added to the second polymer solution.

7. The method of claim 1 wherein the first and second polymers are dissolved together in a first solvent.

8. The method of claim 1 further comprising forming additional polymer layers around said microcapsules.

9. The method of claim 1 further comprising adding other polymers to the polymer-substance solution.

10. The method of claim 1 wherein said nonsolvent is an aqueous solution.

11. The method of claim 10 further comprising adding between 0 and 10% surface active agent to the aqueous solution.

12. The method of claim 11 wherein the surface active agent is an emulsifier.

13. The method of claim 1 wherein the volatile solvents are evaporated at a temperature between 0°

C. and 60°

C.

14. The method of claim 1 wherein said solvent is rapidly evaporated to form spheres of said first polymer within a layer of said second polymer.