Chromatographic purification process

  • US 4,874,843 A
  • Filed: 12/03/1987
  • Issued: 10/17/1989
  • Est. Priority Date: 12/03/1987
  • Status: Expired due to Term
First Claim
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1. A process for purifying fermentation products which comprises:

  • a. contacting an aqueous solution of a fermentation product with a non-functionalized macroporous copolymer of styrene and divinylbenzene in aqueous phase;

    b. physically removing the water from the charged resin;

    c. rewetting the charged resin with a polar organic solvent;

    d. washing the resin with a polar organic solvent that is the same as or different than the polar organic solvent used in step (C) to remove non-uv impurities;

    e. eluting the fermentation product from the non-functional resin by increasing the polarity of the solvent; and

    f. recovering the fermentation product.

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