Means for the application of transdermally absorbable active substances

• US 4,898,592 A
• Filed: 09/16/1988
• Issued: 02/06/1990
• Est. Priority Date: 08/23/1986
• Status: Expired due to Fees

• Current Assignee: Arno W. Latzke, Gert Latzke, Ralf Latzke
• Original Assignee: Arno W. Latzke, Gert Latzke, Ralf Latzke
• Inventors: Latzke, Ralf, Latzke, Arno W., Latzke, Gert
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Lewis, Ralph
• Application Number:
  US07/245,923
• Time in Patent Office: 508 Days
• Field of Search: 604/304-308, 604/890.1, 604/892.1, 128/156, 424/448, 424/449, 424/447
• US Class Current: 604/307
• CPC Class Codes: A61F 2007/0001 Body part
• CPC Class Codes: A61F 2007/0217 Oils
• CPC Class Codes: A61F 2007/0261 medicated
• CPC Class Codes: A61F 7/02 Compresses or poultices for effecting heating or cooling
• CPC Class Codes: A61K 9/703 characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches

Abstract

A device for the application of heated transdermally absorbable active substances has a carrier impregnated with a transdermally absorbable active substance and a support. The support is a laminate made up of one or more polymeric layers and optionally includes a heat conductive element. A preferred mode of carrier attachment involves the use of a magnetic connector.

Claims

1. A device for application of a heated transdermally absorbable active substance to skin, comprising at least one replaceable carrier impregnated with a transdermally absorbable active substance, and a laminate support housing the carrier comprising:

(a) a first closed-cell polyethylene foam layer having a thickness of 2 to 6 mm, said first foam layer including a foil-facing area and a laminate-contacting area defined on a first surface, and an opposite surface,

(b) a second closed-cell polyethylene foam layer having a thickness of 2 to 5 mm, said second foam layer including a laminate-contacting surface bonded to said laminate-contacting area of the first foam layer and an opposite, skin-contacting surface, wherein at least one portion of said second foam layer has been removed to define pink-shaped side walls housing the carrier, and

(c) a flexible heat-conductive metal foil, said metal foil including a first surface facing said foil-contacting surface of the first foam layer and an opposite surface facing said carrier.

2. A device according to claim 1, further comprising a fabric layer laminated onto the opposite surface of the first foam layer.

3. A device according to claim 1, wherein the skin-contacting surface of said second foam layer is covered with a skin-compatible fabric.

4. A device according to claim 1, wherein the support is in the shape of a headband.

5. A device according to claim 1, wherein the support is in the shape of a pad.

6. A device according to claim 1, wherein the skin-contacting surface of the second foam layer is surface texturized.

7. A device for application of a heated transdermally absorbable active substance to skin, comprising at least one replaceable carrier impregnated with a transdermally absorbable active substance, and a laminate support housing the carrier comprising:

(a) a first closed-cell polyethylene foam layer having a thickness of 1 to 5 mm, said first foam layer including a foil-bonding surface and an opposite surface,

(b) a flexible heat-conductive metal foil including a surface bonded to said foil-bonding surface of the first foam layer, and an opposite surface,

(c) a second closed-cell polyethylene foam layer having a thickness of 1 to 4 mm, said second foam layer including a surface bonded to said opposite surface of the metal foil, and an opposite surface, and

(d) a third closed-cell polyethylene foam layer having a thickness of 1 to 4 mm, said third foam layer including a laminate-contacting surface bonded to said opposite surface of the second foam layer and an opposite, skin-contacting surface, wherein at least one portion of said third foam layer has been removed to define side walls surrounding an area housing the carrier, the size of the housing area being equal to or slightly larger than the surface area of the carrier.

8. A device according to claim 7, wherein said side walls define a pinked shape.

9. A device according to claim 7, further comprising a fabric layer laminated onto the opposite surface of the first foam layer.

10. A device according to claim 7, wherein the support is in the shape of a headband.

11. A device according to claim 7, wherein the support is in the shape of a pad.

12. A device according to claim 7, wherein the skin-contacting surface of said third foam layer is covered with a skin-compatible fabric.

13. A device according to claim 7, further comprising a multiple interlocking hook-and-loop type fastener attaching said carrier to said support, said fastener including one side attached to a non-skin-contacting, support-facing surface of the carrier and an opposing side, interlocking with said one side, attached to an area of the opposite surface of the second foam layer facing the carrier, said area of the opposite surface of the second foam layer defining a bottom wall covering the housing area.

14. A device according to claim 7, wherein the skin-contacting surface of the third foam layer is surface texturized.

15. A device for application of a heated transdermally absorbable active substance to skin, comprising at least one replaceable carrier impregnated with a transdermally absorbable active substance, and a laminate support housing the carrier comprising:

(a) a first closed-cell polyethylene foam layer having a thickness of 2 to 5 mm, said first foam layer including a foil-bonding surface and an opposite surface,

(b) a flexible heat-conductive metal foil including a surface bonded to said foil-bonding surface of the first foam layer, and an opposite surface,

(c) a second closed-cell polyethylene foam layer having a thickness of 2 to 5 mm, said second foam layer including a laminate-contacting surface bonded to said opposite surface of the foil and an opposite, skin-contacting surface, wherein at least one portion of said second foam layer has been removed to define side walls surrounding an area housing the carrier, the size of the housing area being equal to or slightly larger than the surface area of the carrier.

16. A device according to claim 15, wherein said side walls define a pinked shaped.

17. A device according to claim 15, further comprising a fabric layer laminated onto the opposite surface of the first foam layer.

18. A device according to claim 15, wherein the support is in the shape of a headband.

19. A device according to claim 15, wherein the support is in the shape of a pad.

20. A device according to claim 15, wherein the skin-contacting surface of said second foam layer is covered with a skin-compatible fabric.

21. A device according to claim 15, further comprising a multiple interlocking hook-and-loop type fastener attaching said carrier to said support, said fastener including one side attached to a non-skin-contacting, support-facing surface of the carrier and an opposing side, interlocking with said one side, attached to an area of the opposite surface of the second foam layer facing the carrier, said area of the opposite surface of the second foam layer defining a bottom wall covering the housing area.

22. A device according to claim 15, wherein the skin-contacting surface of the second foam layer is surface texturized.