Device and method for depletion of the leukocyte content of blood and blood components
DCFirst Claim
1. A device for the depletion of the leukocyte content of a blood product comprising at least first, second, and third preformed porous elements with the second element interposed between the first and third elements, each successive element having a smaller pore diameter than that preceding it, the first element including means for removing gels, the second element including means for removing microaggregates, and the third element including means for removing leukocytes in which at least the third element has a CWST of from greater than 53 to less than 90 dynes/cm.
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Abstract
Devices for the depletion of leukocytes in blood products, preferably comprising an upstream porous element including means for removal of gels, at least one intermediate porous element including means for removal of microaggregates, and a downstream element including means for removal of leukocytes by both adsorption and filtration, preferably with at least one of the elements having been modified to a CWST in excess of 53 dynes/cm.
269 Citations
70 Claims
- 1. A device for the depletion of the leukocyte content of a blood product comprising at least first, second, and third preformed porous elements with the second element interposed between the first and third elements, each successive element having a smaller pore diameter than that preceding it, the first element including means for removing gels, the second element including means for removing microaggregates, and the third element including means for removing leukocytes in which at least the third element has a CWST of from greater than 53 to less than 90 dynes/cm.
- 22. A device for the depletion of the leukocyte content of a blood product comprising at least first, second, and third porous elements with the second element interposed between the first and third elements, each successive element having a smaller pore diameter than that preceding it, the first element including means for removing gels, the second element including means for removing microaggregates, and the third element including means for removing leukocytes, and at least the third element has been modified to a CWST of from greater than 53 to less than 90 dynes/cm.
- 37. A device for the depletion of the leukocyte content of a blood product comprising at least one integral element preformed of synthetic fibers, the surfaces of said fibers having been grafted to give the element a CWST of from greater than 53 to less than 90 dynes/cm.
- 43. A device for the depletion of leukocytes from a blood product comprising at least one preformed fibrous filter element in which the fibers of the element have been radiation-grafted and thereafter hot compressed to form a coherent filter element with a CWST of from greater than 53 to less than 90 dynes/cm.
- 48. A device for the depletion of the leukocyte content of a blood product comprising at least one preformed integral multilayer element of synthetic fibers including a layer having a CWST of from greater than 53 to less than 90 dynes/cm for removing leukocytes.
- 52. A device for filtering a blood product comprising at least three porous elements, the first element composed of at least in part a needled fibrous web, the second element having a smaller pore size than the first, and the third having a CWST of from greater than 53 to less than 90 dynes/cm.
- 68. A device for the depletion of the leukocyte content of a blood product comprising a housing including an inlet and an outlet and defining a fluid flow path between the inlet and the outlet, an upstream porous element, at least one intermediate porous element and a downstream porous element, the upstream element including means for removing gels, the intermediate element including means for removing microaggregates, and the downstream element including means for removing leukocytes and having a CWST of from greater than 53 to less than 90 dynes/cm, the upstream, intermediate, and downstream elements being secured within the housing by an interference fit.
Specification