"Triazolo-pyrimidine intermediates"
First Claim
1. A compound represented by the formula (VII'"'"'):
- ##STR23## where at least one of R2, R3 and R9 represent a group represented by the formula;
--A--OR4 where R4 represents a hydrogen or a lower alkyl group; and
A represents a straight or branched alkylene group having 1 to 6 carbon atoms; and
a remaining group or groups are each independently a hydrogen atom;
a cyano group;
a lower alkyl group which may be substituted by a halogen atom;
a carbamoyl group which may be substituted by a lower alkyl group;
a cycloalkyl group;
or a carboxyl group which may be substituted by a protective group or an eliminatable group which is easily hydrolyzable in a human body, and also when R9 is --A--OR4, R2 and R3 may be combined with each other to form an alkylene group having 3 to 4 carbon atoms;
Z represents a nitrogen atom or a group represented by the formula;
C--R10 where R10 represents a hydrogen atom, a carboxyl group or a lower alkyl group which may be substituted by a hydroxy group or a lower alkoxy group; and
X represents a hydrogen atom, a lower alkyl group, a lower alkoxy group or a halogen atom.
0 Assignments
0 Petitions
Accused Products
Abstract
There are disclosed a β-lactam compound represented by the formula (I): ##STR1## wherein R1 represents an acyl group; M represents a hydrogen atom, a protective group of an eliminatable group which is easily hydrolyzable in a human body; B represents a group represented by the formula (b): ##STR2## where at least one of R2, R3 and R9 represent a group represented by the formula: -A-OR4 where R4 represents a hydrogen or a lower alkyl group; and A represents a straight or branched alkylene group having 1 to 6 carbon atoms; and a remaining group or groups are each independently a hydrogen atom; a cyano group; a lower alkyl group which may be substituted by a halogen atom; a carbamoyl group which may be substituted by a lower alkyl group; a cycloalkyl group; or a carboxyl group which may be substituted by a protective group of an eliminatable group which is easily hydrolyzable in a human body, and also when R9 is -A-OR4, R2 and R3 may be combined with each other to form an alkylene group having 3 to 4 carbon atoms; and Z represents a nitrogen atom or a group represented by the formula: C-R10 where R10 represents a hydrogen atom, a carboxyl group or a lower alkyl group which may be substituted by a hydroxy group or a lower alkoxy group,
or its pharmaceutically acceptable salt, and a process for preparing the same, an intermediate for synthesis of the same and a medicinal composition for bacterially infectious disease therapy containing the same.
10 Citations
3 Claims
-
1. A compound represented by the formula (VII'"'"'):
- ##STR23## where at least one of R2, R3 and R9 represent a group represented by the formula;
--A--OR4 where R4 represents a hydrogen or a lower alkyl group; and
A represents a straight or branched alkylene group having 1 to 6 carbon atoms; and
a remaining group or groups are each independently a hydrogen atom;
a cyano group;
a lower alkyl group which may be substituted by a halogen atom;
a carbamoyl group which may be substituted by a lower alkyl group;
a cycloalkyl group;
or a carboxyl group which may be substituted by a protective group or an eliminatable group which is easily hydrolyzable in a human body, and also when R9 is --A--OR4, R2 and R3 may be combined with each other to form an alkylene group having 3 to 4 carbon atoms;
Z represents a nitrogen atom or a group represented by the formula;
C--R10 where R10 represents a hydrogen atom, a carboxyl group or a lower alkyl group which may be substituted by a hydroxy group or a lower alkoxy group; and
X represents a hydrogen atom, a lower alkyl group, a lower alkoxy group or a halogen atom. - View Dependent Claims (2, 3)
- ##STR23## where at least one of R2, R3 and R9 represent a group represented by the formula;
Specification