Human stem cells and monoclonal antibodies

  • US 4,965,204 A
  • Filed: 06/01/1987
  • Issued: 10/23/1990
  • Est. Priority Date: 02/06/1984
  • Status: Expired due to Term
First Claim
Patent Images

1. A monoclonal antibody which specifically binds to an antigen on non-malignant, immature human marrow cells, wherein said antigen is stage specific and not lineage dependent, and said antigen is also specifically bound by the antibody produced by the hybridoma deposited under ATCC Accession No. HB-8483;

  • (a) which antigen is present on non-malignant, human blood or bone marrow;

    (i) colony-forming cells for granulocytes and monocytes (CFC-GM),(ii) colony-forming cells for erythrocytes (BFU-E),(iii) colony-forming cells for eosinophils (CFC-Eo),(iv) multipotent colony-forming cells (CFC-GEMM), and(v) immature lymphoid precursor cells;

    (b) which antigen is present on a maximum of about 5% non-malignant, human marrow cells and a maximum of about 1% non-malignant, human peripheral blood cells; and

    (c) which antigen is not present on non-malignant, mature human myeloid and lymphoid cells.

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