Electrode array for use in connection with a living body and method of manufacture

• US 4,969,468 A
• Filed: 01/24/1989
• Issued: 11/13/1990
• Est. Priority Date: 06/17/1986
• Status: Expired due to Term

• Current Assignee: Alfred E. Mann Foundation For Scientific Research
• Original Assignee: Alfred E. Mann Foundation For Scientific Research
• Inventors: Schulman, Joseph H., Byers, Charles L., Whitmoyer, David I.
• Primary Examiner(s): Cohen, Lee S.
• Application Number:
  US07/300,859
• Time in Patent Office: 658 Days
• Field of Search: 128/639-642, 128/644, 128/784, 427/79, 427/96, 427/99, 29/829
• US Class Current: 600/373
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61B 5/685 Microneedles
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: Y10T 29/49124 On flat or curved insulated base, e.g., printed circuit, etc.

Abstract

The electrode array is a device for making multiple electrical contacts with cellular tissue or organs. The electrode array includes a base (1), a two dimensional array of conducting protuberances (2) arising from the base and serving as electrodes, and conductors (3) embedded onto the base and connected to such protuberances for transmitting electrical signals to and/or from the protuberances. The protuberances may also include an insulating layer (15) which covers either the entire protuberance or which leaves the tips exposed for making focused electrical contact. Electrode arrays may be used used singly or in combination with a second electrode array so as to form a sandwich around a target tissue. The sandwich electrode array (16, 17) may employ indexing cones for aligning the opposing electrode arrays and for limiting their vertical proximity. The conductors of the electrode array may be electronically connected or coupled to processing circuitry which amplifies and analyzes the signal received from the tissue and/or which generates signals which are sent to the target tissue and possibly coordinates the generated signals with signals which originate with the tissue.

Claims

1. An electrode array for establishing electrical contact with tissue of a living body, the electrode array comprising:

a base having a support surface,

a plurality of electrically conductive protuberances extending substantially perpendicular to and from said support surface of said base in a two dimensional array, each of said protuberances having a tip for electrically contacting the tissue,

a plurality of conductors incorporated onto said base and electrically connected to said protuberances for conducting electric signals to or from said protuberances, and

a dielectric coat covering and electrically insulating said protuberances, exclusive of the tips.

2. An electrode array as described in claim 1 wherein:

said protuberances perpendicularly extend from said base with a range of heights from approximately 0.5 micrometers to on the order of 100 micrometers.

3. An electrode array as described in claim 1 wherein:

said protuberances are adjacently spaced with a range from approximately 0.5 micrometers to on the order of 100 micrometers upon said base.

4. An electrode array as described in claim 1 for establishing an array of electrical contacts with tissue, wherein:

each conductor is electrically connected to at least one of said protuberances for forming a two dimensional array, whereby each tip is capable of establishing an electrical contact with the tissue and the two dimensional array of said protuberances is capable of establishing an array of electrical contacts with the tissue.

5. An electrode array as described in claim 4 further comprising:

a plurality of means for generating a signal,

each of said generating means being electronically coupled to one of said conductors.

6. An electrode array as described in claim 4 further comprising:

means for analyzing a plurality of signals,

said analyzing means being electronically coupled to each of said conductors.

7. An electrode array as described in claim 4 wherein:

said protuberances perpendicularly extend from said base with a range of heights from approximately 0.5 micrometers to on the order of 100 micrometers, and

said protuberances are adjacently spaced with a range from approximately 0.5 micrometers to on the order of 100 micrometers upon said base.

8. An electrode array as described in claim 4 wherein the electrode array electrically contacts individual cellular components of the tissue of the living body and wherein:

each tip of said protuberances is sufficiently small and sharp to be capable of making electrical contact with a single cellular component within the tissue.

9. An electrode array as described in claim 4 wherein:

said dielectric coat has a biocompatible composition for rendering the electrode array implantable into the living body.

10. A capacitor electrode array for capacitively coupling with the tissue of a living body, the capacitor electrode array comprising:

a base having a support surface,

a plurality of electrically conductive protuberances extending substantially perpendicular to and from said support surface of said base in a two dimensional array, each of said protuberances having a tip,

a dielectric coat covering said protuberances for capacitively coupling each of said protuberances with the tissue, and

a plurality of conductors incorporated onto said base and electrically connected to said protuberances for conducting electric signals to or from said protuberances.

11. A capacitor electrode array as described in claim 10 wherein:

said protuberances perpendicularly extend from said base with a range of heights from approximately 0.5 micrometers to on the order of 100 micrometers.

12. A capacitor electrode array as described in claim 10 wherein:

said protuberances are adjacently spaced with a range from approximately 0.5 micrometers to on the order of 100 micrometers upon said base.

13. A capacitor electrode array as described in claim 10 wherein:

said protuberances perpendicularly extend from said base with a range of heights from approximately 0.5 micrometers to on the order of 100 micrometers and

said protuberances are adjacently spaced with a range from approximately 0.5 micrometers to on the order of 100 micrometers upon said base.

14. A capacitor electrode array as described in claim 10 further comprising:

means for generating multiple electric signals,

said generating means being electronically coupled to said conductors.

15. A capacitor electrode array as described in claim 10 further comprising:

means for analyzing multiple electrical signals,

said analyzing means being electronically coupled to said conductors.

16. A combination of two electrode arrays for establishing electrical contact with a nerve, the combination comprising:

a first electrode array including a first base, a first array of electrically conductive protuberances supported by said first base, and a first set of conductors connected to the first array of protuberances,

a second electrode array including a second base, a second array of electrically conductive protuberances supported by said second base, and a second set of conductors connected to the second array of protuberances, and

cooperative means extending from the first and second bases for indexing and aligning the first electrode array opposite the second electrode array with the nerve sandwiched between the first and second electrode arrays and with the first and second array of protuberances penetrating and contacting the nerve.

17. A combination of two electrode arrays for capacitively coupling with a nerve, the combination comprising:

a first capacitor electrode array including a first base, a first array of electrically capacitive protuberances having a dielectric coat supported by the first base, and a first set of conductors connected to the first array of protuberances,

a second capacitor electrode array including a second base, a second array of electrically capacitive protuberances having a dielectric coat supported by the second base, and a second set of conductors connected to the second array of protuberances, and

cooperative means extending from the first and second bases for indexing and aligning the first capacitor electrode array opposite the second capacitor electrode array with the nerve sandwiched between the first and second capacitor electrode arrays and with the first and second array of capacitive protuberances penetrating and capacitively coupling with the nerve.

18. A method for establishing electrical contact with a nerve from a living body, the method comprising the following steps:

step (a);

contacting the nerve with a combination of two electrode arrays including a first electrode array, a second electrode array, and indexing means,

the first electrode array including a first base, a first array of electrically conductive protuberances supported by the first base, and a first set of conductors connected to the first array of protuberances,

the second electrode array including a second base, a second array of electrically conductive protuberances supported by the second base, and a second set of conductors connected to the second array of protuberances, and

the indexing means extending from the first and second bases for indexing and aligning the first electrode array opposite the second electrode array with the nerve sandwiched between the first and second electrode arrays and with the first and second array of protuberances penetrating and contacting the nerve, and

step (b);

connecting both the first and second set of conductors of each electrode array with electrical circuits.

19. A method for capacitively coupling to a nerve from a living body, the method comprising the following steps:

step (a);

contacting the nerve with a combination of two capacitive electrode arrays including a first capacitive electrode array, a second capacitive electrode array, and indexing means,

the first capacitive electrode array including a first base, a first array of electrically conductive protuberances supported by the first base, and a first set of conductors connected to the first array of protuberances, and

the second capacitive electrode array including a second base, a second array of electrically conductive protuberances supported by the second base, and a second set of conductors connected to the second array of protuberances, and

the indexing means for indexing and aligning the first capacitive electrode array opposite the second capacitive electrode array with the nerve sandwiched between the first and second capacitive electrode arrays and with the first and second arrays of protuberances penetrating and capacitively coupling with the nerve, and

step (b);

connecting both the first and second set of conductors of each electrode array with electrical circuits.

20. A method for making an electrode array comprising the steps of:

(a) obtaining a base with a non-conductive surface;

(b) depositing a layer of electrically conductive material atop the non-conductive surface;

(c) forming conductors on the base by partially removing the layer of electrically conductive material;

(d) defining sites upon the conductors for an array of protuberances;

(e) depositing electrically conductive protuberances upon the sites for the array; and

(f) forming a dielectric coat upon the protuberances.