Composition, apparatus and method for sensing ionic components

• US 4,999,306 A
• Filed: 04/28/1988
• Issued: 03/12/1991
• Est. Priority Date: 10/10/1986
• Status: Expired due to Term

• Current Assignee: Terumo Cardiovascular Systems Corporation (Terumo Corporation)
• Original Assignee: 3M Company
• Inventors: Hui, Henry K., Yafuso, Masao
• Primary Examiner(s): Lacey, David L.
• Assistant Examiner(s): Johnston, Jill
• Application Number:
  US07/188,414
• Time in Patent Office: 1,048 Days
• Field of Search: 422/58, 422/68, 422/82.06, 422/82.07, 436/68, 436/163, 436/172, 128/634, 250/227, 250/461.1, 250/227.14, 350/96.3, 356/39
• US Class Current: 436/68
• CPC Class Codes: G01N 2021/6434 Optrodes
• CPC Class Codes: G01N 2021/6439 with indicators, stains, dyes, tags, labels, marks
• CPC Class Codes: G01N 21/643 non-biological material
• CPC Class Codes: G01N 21/80 Indicating pH value

Abstract

A composition of matter useful for sensing the concentration of an ionic component in a medium comprising a cationic or anionic matrix material and a sensing component chemically bonded to the matrix material and being effective to provide a signal in response to the presence of the ionic component in the medium.

Claims

1. A composition of matter useful for sensing the concentration of an ionic component in a medium, comprising:

a matrix material having a cationic or anionic charge therewithin; and

a sensing component chemically bonded to said matrix material and being effective to provide a signal in response to the presence of said ionic component in said medium;

wherein said matrix material has sufficient cationic or anionic charge distributed within said matrix material such that the apparent ionic concentration sensed by said sensing component within said matrix material is higher or lower than the actual ionic concentration in said medium.

2. The composition of claim 1 wherein said sensing component is covalently bonded to said matrix material.

3. The composition of claim 1 wherein said ionic component is H⁺ or OH^-.

4. The composition of claim 1 wherein said signal varies as the concentration of said ionic component in said medium varies.

5. The composition of claim 1 wherein said sensing component is an optical indicator.

6. The composition of claim 1 wherein said sensing component is a fluorescence indicator.

7. The composition of claim 1 wherein said matrix material is polymeric.

8. A composition of matter useful for sensing the concentration of an ionic component in a medium, said composition comprising a combination of at least two of:

(1) a matrix material having a cationic charge therewithin and a first sensing component within said cationic matrix material, said first sensing component within said cationic matrix material being effective to provide a signal in response to the presence of said ionic component in said medium in a first concentration range;

(2) a substantially nonionic matrix material and a second sensing component within said nonionic matrix material, said second sensing component within said nonionic matrix material being effective to provide a signal in response to the presence of said ionic component in said medium in a second concentration range; and

(3) a matrix material having an anionic charge therewithin and a third sensing component within said anionic matrix material, said third sensing component within said anionic matrix material being effective to provide a signal in response to the presence of said ionic component in said medium in a third concentration range;

wherein said first, second, and third sensing components are made from the same indicator material.

9. The composition of claim 8 wherein said first, second, and third sensing components are chemically bonded to said cationic, substantially nonionic, and anionic matrix materials, respectively.

10. The composition of claim 8 wherein said first, second, and third sensing components are covalently bonded to said cationic, substantially nonionic, and anionic matrix materials, respectively.

11. The composition of claim 8 comprising the combination of all of (1), (2), and (3).

12. The composition of claim 8 wherein said first, second, and third sensing components are optical indicators made from the same optical indicator material.

13. The composition of claim 8 wherein said first, second, and third sensing components are fluorescence indicators made from the same fluorescence indicator material.

14. The composition of claim 8 wherein said ionic component is H⁺ or OH^-.

15. An apparatus for measuring the concentration of an ionic component in a medium, comprising:

sensor means including a matrix material having a cationic or anionic charge therewithin, and a sensing component chemically bonded to said matrix material and being effective to provide a signal in response to the presence of said ionic component in said medium, wherein said matrix material has sufficient cationic or anionic charge distributed within said matrix material such that the apparent ionic concentration sensed by said sensing component within said matrix material is higher or lower than the actual ionic concentration in said medium; and

signal means capable of transmitting said signal from said sensing component.

16. The apparatus of claim 15 wherein said sensing component is covalently bonded to said matrix material.

17. The apparatus of claim 15 wherein said ionic component is H⁺ or OH^-.

18. The apparatus of claim 15 wherein said signal varies as the concentration of said ionic component in said medium varies.

19. The apparatus of claim 15 wherein said sensing component is an optical indicator.

20. The apparatus of claim 19 wherein said signal means comprises an optical fiber.

21. The apparatus of claim 15 wherein said sensing component is a fluorescence indicator.

22. The apparatus of claim 21 wherein said signal means comprises an optical fiber.

23. An apparatus for measuring the concentration of an ionic component in a medium, comprising:

sensor means including a combination of at least two of;

(1) a matrix material having a cationic charge therewithin and a first sensing component within said cationic matrix material, said first sensing component within said cationic matrix material being effective to provide a signal in response to the presence of said ionic component in said medium in a first concentration range;

(2) a substantially nonionic matrix material and a second sensing component within said nonionic matrix material, said second sensing component within said nonionic matrix material being effective to provide a signal in response to the presence of said ionic component in said medium in a second concentration range; and

(3) a matrix material having an anionic charge therewithin and a third sensing component within said anionic matrix material, said third sensing component within said anionic matrix material being effective to provide a signal in response to the presence of said ionic component in said medium in a third concentration range;

wherein said first, second, and third sensing components are made from the same indicator material; and

signal means capable of transmitting said signals from said first, second, and third sensing components.

24. The apparatus of claim 23 wherein said first, second, and third sensing components are chemically bonded to said cationic, substantially nonionic, and anionic matrix materials, respectively.

25. The apparatus of claim 23 wherein said first, second, and third sensing components are covalently bonded to said cationic, substantially nonionic, and anionic matrix materials, respectively.

26. The apparatus of claim 23 wherein said sensor means includes the combination of all of (1), (2), and (3).

27. The apparatus of claim 23 wherein said ionic component is H⁺ or OH^-.

28. The apparatus of claim 23 wherein said first, second, and third sensing components are optical indicators made from the same optical indicator material.

29. The apparatus of claim 28 wherein said signal means comprises an optical fiber.

30. The apparatus of claim 23 wherein said first, second, and third sensing components are fluorescence indicators made from the same fluorescence indicator material.

31. The apparatus of claim 30 wherein said signal means comprises an optical fiber.

32. A method for sensing the concentration of an ionic component in a medium, comprising:

contacting said medium with a composition comprising;

a matrix material having a cationic or anionic charge therewithin; and

a sensing component chemically bonded to said matrix material and being effective to provide a signal in response to the presence of said ionic component in said medium;

wherein said matrix material has sufficient cationic or anionic charge distributed within said matrix material such that the apparent ionic concentration sensed by said sensing component within said matrix material is higher or lower than the actual ionic concentration in said medium; and

analyzing said signal to determine the concentration of said ionic component in said medium.

33. The method of claim 32 wherein said sensing component is covalently bonded to said matrix material.

34. The method of claim 32 wherein said ionic component is H⁺ or OH^-.

35. The method of claim 32 wherein said signal varies as the concentration of said ionic component in said medium varies.

36. The method of claim 32 wherein said sensing component is a fluorescence indicator.

37. The method of claim 32 wherein said matrix material is polymeric.

38. The method of claim 32 wherein said sensing component is an optical indicator.

39. The method of claim 38 wherein said signal is transmitted prior to being analyzed.

40. The method of claim 39 wherein said signal is transmitted by an optical fiber.

41. A method for sensing the concentration of an ionic component in a medium, comprising:

contacting said medium with a composition comprising a combination of at least two of;

(1) a matrix material having a cationic charge therewithin and a first sensing component within said cationic matrix material, said first sensing component within said cationic matrix material being effective to provide a signal in response to the presence of said ionic component in said medium in a first concentration range;

(2) a substantially nonionic matrix material and a second sensing component within said nonionic matrix material, said second sensing component within said nonionic matrix material being effective to provide a signal in response to the presence of said ionic component in said medium in a second concentration range; and

(3) a matrix material having an anionic charge therewithin and a third sensing component within said anionic matrix material, said third sensing component within said anionic matrix material being effective to provide a signal in response to the presence of said ionic component in said medium in a third concentration range;

wherein said first, second, and third sensing components are made from the same indicator material; and

analyzing said signal or signals provided by said sensing components to determine the concentration of said ionic component in said medium.

42. The method of claim 41 wherein said composition comprises the combination of all of (1), (2), and (3).

43. The method of claim 41 wherein said first, second, and third sensing components are chemically bonded to said cationic, substantially nonionic, and anionic matrix materials, respectively.

44. The method of claim 41 wherein said first, second, and third sensing components are covalently bonded to said cationic, substantially nonionic, and anionic matrix materials, respectively.

45. The method of claim 41 wherein said first, second, and third sensing components are fluorescence indicators made from the same fluorescence indicator material.

46. The method of claim 41 wherein said ionic component is H⁺ or OH^-.

47. The method of claim 41 wherein said first, second, and third sensing components are optical indicators made from the same optical indicator material.

48. The method of claim 47 wherein each said signal is transmitted prior to being analyzed.

49. The method of claim 48 wherein each said signal is transmitted by an optical fiber.