Intraoperative beta probe and method of using the same

• US 5,008,546 A
• Filed: 06/18/1990
• Issued: 04/16/1991
• Est. Priority Date: 06/18/1990
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Hoffman, Edward J., Mazziotta, John C., Daghighian, Farhad
• Primary Examiner(s): Berman, Jack I.
• Assistant Examiner(s): HANIG, RICHARD E
• Application Number:
  US07/539,794
• Time in Patent Office: 302 Days
• Field of Search: 250/366, 250/367, 250/308, 250/303, 250/486.1, 250/482.1, 250/370.11, 128/654
• US Class Current: 250/366
• CPC Class Codes: A61B 6/425 using detectors specially adapted to be used in the interior of the body
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: G01T 1/161 Applications in the field of nuclear medicine, e.g. in vivo counting apparatus for radiation diagnosis A61B6/00
• CPC Class Codes: G01T 1/169 Exploration, location of contaminated surface areas
• CPC Class Codes: G01T 1/20 with scintillation detectors

Abstract

An intraoperative radiation probe is devised to detect radiolabelled malignant tissues by being selectively sensitive to beta radiation while insensitive to gamma radiation. The probe is comprised of two plastic scintillators optically coupled to corresponding photomultiplier tubes via corresponding light pipes. One of the plastic scintillators is shielded against beta radiation while the other is left to detect both beta and gamma radiation. The gamma radiation sensitivity of the dual probes is empirically established and used as a weighted factor to subtract the outputs of the two probes to leave a signal indicative of the beta radiation emitted by the radiolabelled tissue. Because of the shorter range of beta radiation within tissue, only near radiolabelled tissue is detected by the probe while strongly radiolabelled, more distant tissues exposing the probe to gamma radiation are ignored. The reliably identified near radiolabelled tissues can then be surgically removed. The probe is usable in any application where local beta radiation is to be differentiated from other types and sources of radiation.

Claims

1. A probe system for preferentially detecting beta radiation over background gamma radiation from a source of beta and gamma radiation comprising:

a first means for detecting beta and gamma radiation at an arbitrarily selected location; and

a second means for selectively detecting only one type of radiation of said beta and gamma radiation, said second and first means coupled together,

whereby beta radiation from near sources is reliably detected and differentiated from gamma radiation emitted from far sources.

2. The probe system of claim 1 wherein said first means comprises a scintillation detector and said second means comprises a circuit for adjusting the detection threshold energy of said scintillation detector above the Compton edge of said source of beta and gamma radiation.

3. The probe system of claim 1:

wherein said first means comprises a first scintillation detector arranged and configured to detect beta and gamma radiation from said source; and

wherein said second means comprises a second scintillation detector for detecting only gamma radiation from said source and means for generating a weighted difference between said outputs of said first and second detectors, said difference being representative of beta radiation detection by said probe system.

4. The probe system of claim 3 wherein said second scintillation detector is identical to said first scintillation detector and further comprises means for shielding said second scintillation detector from beta radiation.

5. The probe system of claim 4 wherein said means for shielding said second scintillation detector is a conductive covering of a predetermined thickness sufficient to absorb substantially all beta radiation emitted by said source.

6. The probe system of claim 2 wherein said scintillation detector comprises:

a plastic scintillator;

a light tube optically coupled to said plastic scintillator; and

circuit means for converting light received through said light tube from said plastic scintillator into an electrical signal.

7. The probe system of claim 3 wherein said scintillation detector comprises:

a plastic scintillator;

a light tube optically coupled to said plastic scintillator; and

circuit means for converting light received through said light tube from said plastic scintillator into an electrical signal.

8. The probe system of claim 5 wherein said scintillation detector comprises:

a plastic scintillator;

a light tube optically coupled to said plastic scintillator; and

circuit means for converting light received through said light tube from said plastic scintillator into an electrical signal.

9. The probe system of claim 6 further comprising means for rendering said plastic scintillator light tight without substantial interference to penetration of beta and gamma radiation into said plastic scintillator.

10. A dual probe system for preferentially detecting beta radiation emitted by radiopharmaceutically marked tissue marked with isotopes emitting beta and gamma radiation in intraoperative surgery comprising:

a first detector for detecting beta and gamma radiation, said first detector having an output;

a second detector for detecting gamma radiation, said second detector having an output; and

means for subtracting a weighted value of said output of said second detector from said output of said first detector to derive a signal indicative of beta radiation detected from said tissue by said dual probe system,

whereby the location of radioactively tagged tissues may be reliably and accurately identified utilizing beta radiation notwithstanding gamma radiation originating in adjacent tissues.

11. The dual probe system of claim 10 wherein said first and second detectors are scintillation detectors utilizing a plastic scintillator.

12. The dual probe system of claim 11 wherein said first and second detectors further comprise a first and second corresponding photomultiplier tube means for generating an electrical signal in response to an optical input, and light conveyance means for coupling scintillation events within said first and second plastic scintillators to said first and second photomultiplier tube means respectively.

13. The dual probe system of claim 10 wherein said second detector comprises means for shielding said second detector from beta radiation.

14. The dual probe system of claim 13 further comprising means for rendering said first and second detectors light tight without substantially interfering with beta and gamma radiation detection by said detectors.

15. The dual probe system of claim 10 wherein said means for subtracting uses a weighted factor empirically determined by flooding said first and second detector with gamma radiation only and generating a ratio of their respective gamma radiation sensitivities.

16. A method for intraoperatively identifying the location of small masses of radioactively tagged tissues comprising the steps of:

detecting beta and gamma radiation from said tissue in a first detector;

simultaneously detecting at substantially the same location gamma radiation from said tissue in a second detector; and

comparing the amount of beta and gamma radiation detected by said first detector with the amount of gamma radiation detected by said second detector to generate a weighted difference of the amount of radiation detected by said first and second detectors representative of the amount of beta radiation emitted by said tissue,

whereby small masses of tissue radioactively tagged with beta and gamma radiation isotopes may be detected near said location of said first and second detectors notwithstanding the presence of gamma radiation from said tissue more distantly located from said location.

17. The method of claim 16 wherein said steps of detecting said beta and gamma radiation and detecting said gamma radiation are performed in said first and second detectors by exposing said first detector to beta and gamma radiation while simultaneously exposing said second detector only to gamma radiation by the step of providing a beta radiation shield for said second detector.

18. The method of claim 17 further comprising the step of shielding said first and said second detectors from light without thereby providing substantial shielding from beta and gamma radiation.

19. An improvement in a method for intraoperatively locating small masses of radioactively tagged tissues in the presence of radioactively tagged distant tissue masses each tagged with a radioactive isotope comprising the steps of:

providing a scintillation detector having a plastic scintillator capable of detecting beta and gamma radiation; and

adjusting the threshold energy detectable by said scintillation detector to an energy threshold set at the Compton edge of said radioactive isotope,

whereby radioactively tagged near tissue is located notwithstanding the existence of gamma generating radioactively tagged distant tissue.

20. The improvement of claim 19 further comprising the step of rendering said scintillation detector light tight without substantially interfering with detection of beta and gamma radiation by said scintillation detector.