Hemodiafiltration system
First Claim
1. A process for purifying a body fluid by combined dialysis and filtration, comprising:
- (a) flowing the body fluid to be purified past one side of a semi-permeable membrane;
(b) simultaneously flowing dialyzate past the opposite side of said semi-permeable membrane, said flowing steps (a) and (b) being under conditions sufficient to permit purification of the body fluid by dialysis;
(c) over a first time span, and concurrently with said dialysis, causing the pressure on the dialyzate side of said semi-permeable membrane to be less than the pressure on the body fluid side thereof, said first time span and said pressure difference being sufficient to force middle and small molecular weight molecules to travel from the body fluid side to the dialyzate side of said semi-permeable membrane by filtration;
(d) over a second time span, subsequent to said first time span and concurrently with said dialysis, causing the pressure on the dialyzate side of said semi-permeable membrane to be greater than the pressure on the body fluid side thereof, said second time span and said pressure difference being sufficient to cause infusion through said semi-permeable membrane of an amount of dialyzate which is compensatory for the amount of fluid passing from the body fluid side to the dialyzate side during said first time span; and
(e) repeating said steps (c) and (d) in a manner such that alternating pressure differences occur across the same portion of said semi-permeable membrane at a rate which ensures efficient combined filtration and dialysis.
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Accused Products
Abstract
A hemodiafiltration system which enables concurrent performance, in a single system, of hemodialysis and hemofiltration includes a dialyzer, consisting of a casing and at least one semipermeable membrane accommodated therein for dialyzing and purifying body fluid such as blood, plasma, etc., through contacting of the body fluid and dialyzate via the semipermeable membrane, and pumps for causing the dialyzate to flow through the dialyzer. A controller repeatedly changes the difference between the inflow amount of the dialyzate into the dialyzer per unit time and the outflow amount of the same from the dialyzer per unit time from a positive value to a negative value and then from negative to positive, whereby the repeated operation of taking or sucking out aqueous component or constituent and accompanying waste molecules from the body fluid followed by infusing or forcing a compensatory amount of dialyzate into the body fluid is made possible.
105 Citations
8 Claims
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1. A process for purifying a body fluid by combined dialysis and filtration, comprising:
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(a) flowing the body fluid to be purified past one side of a semi-permeable membrane; (b) simultaneously flowing dialyzate past the opposite side of said semi-permeable membrane, said flowing steps (a) and (b) being under conditions sufficient to permit purification of the body fluid by dialysis; (c) over a first time span, and concurrently with said dialysis, causing the pressure on the dialyzate side of said semi-permeable membrane to be less than the pressure on the body fluid side thereof, said first time span and said pressure difference being sufficient to force middle and small molecular weight molecules to travel from the body fluid side to the dialyzate side of said semi-permeable membrane by filtration; (d) over a second time span, subsequent to said first time span and concurrently with said dialysis, causing the pressure on the dialyzate side of said semi-permeable membrane to be greater than the pressure on the body fluid side thereof, said second time span and said pressure difference being sufficient to cause infusion through said semi-permeable membrane of an amount of dialyzate which is compensatory for the amount of fluid passing from the body fluid side to the dialyzate side during said first time span; and (e) repeating said steps (c) and (d) in a manner such that alternating pressure differences occur across the same portion of said semi-permeable membrane at a rate which ensures efficient combined filtration and dialysis. - View Dependent Claims (2, 3, 4)
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5. An apparatus for purifying a body fluid by combined dialysis and filtration, comprising
(a) dialyzer means including a casing, a semi-permeable membrane, dialyzate inlet and outlet passages, and body fluid inlet and outlet passages, for permitting the simultaneous flow of dialyzate on one side of the membrane and flow of body fluid on the other side of the membrane; -
(b) pressure differential means communicating with said dialyzer means for causing variation of the pressure on the dialyzate side of said semi-permeable membrane with respect to that on the body fluid side thereof such that said pressure can be varied between a state at which the pressure on the dialyzate side of said semi-permeable membrane is less than the pressure on the body fluid side thereof and a state at which the pressure on the dialyzate side of said semi-permeable membrane is greater than the pressure on the body fluid side thereof; and (c) control means connected to said pressure differential means for controlling said pressure differential means, when the apparatus is in use, to cause the pressure on the dialyzate side of said semi-permeable membrane to be less than the pressure on the body fluid side thereof for sufficient time and with a sufficient pressure difference to force middle and small molecular weight molecules to travel from the body fluid side to the dialyzate side of said semi-permeable membrane by filtration, to subsequently cause the pressure on the dialyzate side of said semi-permeable membrane to be greater than the pressure on the body fluid side thereof for a period of time and with sufficient pressure difference to cause infusion through said semi-permeable membrane of an amount of dialyzate which is compensatory for the amount of fluid passing from the body fluid side to the dialyzate side during said first time span and for repeating said first and second time spans in a manner such that alternating pressure differences occur across the same portion of said semi-permeable membrane at a rate which ensures sufficient combined filtration and dialysis. - View Dependent Claims (6, 7, 8)
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Specification