Module for determining diffusing capacity of the lungs for carbon monoxide and method

• US 5,022,406 A
• Filed: 12/22/1989
• Issued: 06/11/1991
• Est. Priority Date: 08/01/1988
• Status: Expired due to Fees

• Current Assignee: Harold W. Tomlinson
• Original Assignee: Harold W. Tomlinson
• Inventors: Tomlinson, Harold W.
• Primary Examiner(s): Green, Randall L.
• Assistant Examiner(s): REICHLE, KARIN M
• Application Number:
  US07/455,263
• Time in Patent Office: 536 Days
• Field of Search: 128/719, 128/730, 128/716, 128/718, 128/725
• US Class Current: 600/532
• CPC Class Codes: A61B 5/0813 Measurement of pulmonary parameters by tracers, e.g. radioactive tracers
• CPC Class Codes: A61B 5/087 Measuring breath flow
• CPC Class Codes: G01N 33/497 of gaseous biological material, e.g. breath

Abstract

An apparatus for introducing test gas commonly containing an inert gas and carbon monoxide to a patient through a mouthpiece which, in turn, is attached to a sample chamber within which are arranged sensors enabling measuring of carbon monoxide, carbon dioxide, an inert gas or other gases. Valving permits the test gas to be inhaled by the patient and then exhaled into the chamber. Further valving at the outlet of the chamber permits evacuation through a gas volume measuring device after measurements within the chamber have been completed. Sample chambers may be of various shapes but preferred forms are essentially linear or closed loop arrangements.

Claims

1. An apparatus for determining the various parameters related to the interaction of human lungs with one or more specified gases, comprising:

a sample chamber;

means within the chamber for sensing the gaseous components of the contents of the chamber;

mixing means within the chamber for mixing the gaseous components of the contents of the chamber;

a mouthpiece connected into said sample chamber for input of gases expired from the lungs of a patient under test;

a test gas input connection attached at one end to the sample chamber and having means for connection with a source of standard test gas containing a predetermined concentration of one or more specified gases and valve means, including a demand valve, for allowing test gas to flow from the source through the sample chamber to the mouthpiece by its own pressure or on demand when the patient inspires through the mouthpiece;

mouthpiece valve means between the mouthpiece and the sample chamber for opening to enable the standard test gas to flow to the mouthpiece through at least a portion of the sample chamber, closing entirely for a predetermined breath hold period and then opening to enable expired gases to be breathed out into the sample chamber;

rebreath valve means between the mouthpiece and the mouthpiece valve means for connecting the mouthpiece to the atmosphere to allow normal breathing by the patient whereby the air inspired and the gases expired do not come from or go into the sample chamber when the rebreath valve means is open and the mouthpiece valve means is closed;

a gas volume measuring device between the test gas input connection and the sample chamber to measure the gas volume entering and exiting the sample chamber;

an exhaust valve between the gas volume measuring device and the test gas input connection to control exit of gases from the sample chamber; and

pneumotach valve means between the sample chamber and the exhaust valve for allowing connection of the chamber to the exhaust valve, whereby, by opening and closing the mouthpiece, rebreath and pneumotach valve means and exhaust valve, sequential portions of the expired gases can pass through the exhaust valve, be trapped and held in the chamber for mixing and measurement of its gaseous constituents by the mixing and sensing means within the chamber, respectively, and be passed to the atmosphere without entering the chamber, so that in addition to gas volume measurement as the gases leave the chamber, measurement may be made of expired gaseous constituents related to lung effectiveness using the sensing means within the chamber.

2. The apparatus of claim 1 in which the test gas includes a predetermined concentration of carbon monoxide and the sensing means includes a carbon monoxide sensor to measure the quantity of carbon monoxide present in the contents of the sample chamber.

3. The apparatus of claim 1 in which the sensing means includes means for measuring the quantity of carbon dioxide present in the contents of the sample chamber.

4. The apparatus of claim 1 in which the test gas includes a predetermined concentration of helium and the sensing means includes helium gas measurement means to measure the quantity of helium present in the contents of the sample chamber.

5. The apparatus of claim 1 in which the test gas contains predetermined concentrations of both carbon monoxide and helium and the sensing means includes means for measuring the quantities of carbon monoxide and helium as well as carbon dioxide present in the contents of the sample chamber.

6. The apparatus of claim 5 in which the means for measuring helium include an ultrasound generator and an ultrasound detector spaced a fixed distance apart to measure the amount of helium in the sample chamber by its effect upon sound propagation between the ultrasound generator and the ultrasound detector.

7. The apparatus of claim 1 in which the chamber is configured as a closed loop with four-way valve means, having two alternative positions, located therein to enable in the first position for introduction of the expired gases from the mouthpiece into and through substantially the entire loop including the portion having the sensing means therein and in the second position for introduction of the standard test gas through the sample chamber to the mouthpiece without passing through the portion having the sensing means therein.

8. The apparatus of claim 7 in which temperature sensing means is provided in the vicinity of the means for sensing the gaseous components of the contents of the chamber.

9. The apparatus of claim 1 in which the sample chamber defines a substantially linear path between the mouthpiece valve means and the pneumotach valve means and said mixing means and said sensing means are located along said substantially linear path.

10. The apparatus of claim 1 in which the gas volume measuring device is located between the mouthpiece valve means and the pneumotach valve means.

11. A method of measuring the diffusing capacity of lungs using an apparatus as claimed in claim 1, comprising the following steps:

connecting the means for connection with a source of standard test gas;

connecting the mouthpiece to the mouth of a patient;

opening the rebreath valve means and closing the mouthpiece valve means and having the patient expire to residual volume;

closing the rebreath valve means and opening the mouthpiece and pneumotach valve means and having the patient inspire so that the test gas will flow through the volume measuring device, sample chamber and mouthpiece;

closing the mouthpiece and pneumotach valve means thereby closing the sample chamber off from the patient and the remainder of the apparatus for a predetermined period;

opening the mouthpiece and pneumotach valve means and having the patient expire through the mouthpiece, the mouthpiece valve means, the sample chamber, the pneumotach valve means and the volume measuring device;

closing the mouthpiece and pneumotach valve means thereby closing the sample chamber off from the mouthpiece and exhaust valve and retaining a sample of expired gases in the sample chamber after a predetermined volume of expired gases has passed through the volume measuring device;

mixing the expired gas sample and measuring the gaseous constituents of the contents of the sample chamber by said mixing and sensing means, respectively, within the sample chamber; and

opening the rebreath valve means and having the patient expire the balance of the expired gases to the atmosphere without entering the sample chamber.

12. An apparatus for determining the various parameters related to the interaction of human lungs with one or more specified gases, comprising:

a sample chamber;

means within the chamber for sensing the gaseous components of the contents of the chamber;

mixing means within the chamber for mixing the gaseous components of the contents of the chamber;

a mouthpiece connected into said sample chamber for input of gases expired from the lungs of a patient under test;

a test gas input connection attached at one end to the sample chamber and having means for connection with a source of standard test gas containing a predetermined concentration of one or more specified gases and valve means, including a demand valve, for allowing test gas to flow from the source through the sample chamber to the mouthpiece by its own pressure or on demand when the patient inspires through the mouthpiece;

mouthpiece valve means between the mouthpiece and the sample chamber for opening to enable the standard test gas to flow to the mouthpiece through at lest a portion of the sample chamber, closing entirely for a predetermined breath hold period and then opening to enable expired gases to be breathed out into the sample chamber;

rebreath valve means between the mouthpiece and the mouthpiece valve means for connecting the mouthpiece to the atmosphere to allow normal breathing by the patient whereby the air inspired and the gases expired do not come from or go into the sample chamber when the rebreath valve means is open and the mouthpiece valve means is closed;

a gas volume measuring device between the test gas input connection and the mouthpiece to measure the gas volume entering and exiting the sample chamber; and

a pneumotach valve means separated from the mouthpiece valve means by at least the sample chamber for closing off the sample chamber for preventing flow out of the sample chamber or into the sample chamber;

an exhaust valve between the rest of the apparatus and the test gas input connection to control exit of gases from the sample chamber,

whereby, by opening and closing the mouthpiece, pneumotach and rebreath valve means and exhaust valve, sequential portions of the expired gases can pass through the exhaust valve, be trapped and held in the chamber for mixing and measurement of its gaseous constituents by the mixing and sensing means within the chamber, respectively, so that in addition to gas volume measurement, measurement may be made of expired gaseous constituents related to lung effectiveness using the sensing means within the chamber.

13. The apparatus of claim 12 in which the test gas includes a predetermined concentration of carbon monoxide and the sensing means includes a carbon monoxide sensor to measure the quantity of carbon monoxide present in the contents of the sample chamber.

14. The apparatus of claim 12 in which the sensing means includes means for measuring the quantity of carbon dioxide present in the contents of the sample chamber.

15. The apparatus of claim 12 in which the test gas includes a predetermined concentration of helium and the sensing means includes helium gas measurement means to measure the quantity of helium present in the contents of the sample chamber.

16. The apparatus of claim 12 in which the test gas contains predetermined concentrations of both carbon monoxide and helium and the sensing means includes means for measuring the quantities of carbon monoxide and helium as well as carbon dioxide present in the contents of the sample chamber.

17. The apparatus of claim 16 in which the means for measuring helium include an ultrasound generator and an ultrasound detector spaced a fixed distance apart to measure the amount of helium in the sample chamber by its effect upon sound propagation between the ultrasound generator and the ultrasound detector.

18. The apparatus of claim 12 in which the chamber is configured as a closed loop with four-way valve means, having two alternative positions, located therein to enable in the first position for introduction of the expired gases from the mouthpiece into and through substantially the entire loop including the portion having the sensing means therein and in the second position for introduction of the standard test gas through the sample chamber to the mouthpiece without passing through the portion having the sensing means therein.

19. The apparatus of claim 18 in which temperature sensing means is provided in the vicinity of the means for sensing the gaseous components of the contents of the chamber.

20. The apparatus of claim 12 in which the sample chamber defines a substantially linear path between the mouthpiece valve means and the pneumotach valve means and said mixing means and said sensing means are located along said substantially linear path.

21. The apparatus of claim 12 in which the gas volume measuring device is located between the mouthpiece valve means and the pneumotach valve means.

22. A method of measuring the diffusing capacity of lungs using an apparatus as claimed in claim 14, comprising the following steps:

connecting the means for connection with a source of standard test gas;

connecting the mouthpiece to the mouth of a patient;

opening the rebreath valve means and closing the mouthpiece valve means and having the patient expire to residual volume;

closing the rebreath valve means and opening the mouthpiece and pneumotach valve means and having the patient inspire so that the test gas will flow through the volume measuring device, sample chamber and

mouthpiece;

closing the mouthpiece and pneumotach valve means thereby closing the sample chamber off from the patient and the remainder of the apparatus for a predetermined period;

opening the mouthpiece and pneumotach valve means and having the patient expire through the mouthpiece, the mouthpiece valve means, the sample chamber, the pneumotach valve means and the volume measuring device;

closing the mouthpiece and pneumotach valve means thereby closing the sample chamber off from the mouthpiece and exhaust valve and retaining a sample of expired gases in the sample chamber after a predetermined volume of expired gases has passes through the volume measuring device;

mixing the expired gas sample and measuring the gaseous constituents of the contents of the sample chamber by said mixing and sensing means, respectively, within the sample chamber; and

opening the rebreath valve means and having the patient expire the balance of the expired gases to the atmosphere without entering the sample chamber.

23. A method of measuring the diffusing capacity of lungs using an apparatus as claimed in claim 14, comprising the following steps:

connecting the means for connection with a source of standard test gas;

connecting the mouthpiece to the mouth of a patient;

opening the rebreath valve means and closing the mouthpiece valve means and having the patient expire to residual volume;

closing the rebreath valve means and opening the mouthpiece and pneumotach valve means and having the patient inspire so that the test gas will flow through the volume measuring device, sample chamber and mouthpiece;

closing the mouthpiece and pneumotach valve means thereby closing the sample chamber off from the patient and the remainder of the apparatus for a predetermined period;

opening the mouthpiece and pneumotach valve means and having the patient expire through the mouthpiece, the mouthpiece valve means, the sample chamber, and the volume measuring device;

closing the mouthpiece, pneumotach and exhaust valve means thereby closing the sample chamber off from the mouthpiece and retaining a sample of expired gases in the sample chamber after a predetermined volume of expired gases has passed through the volume measuring device; and

mixing the expired gas sample and measuring the gaseous constituents of the contents of the sample chamber by said mixing and sensing means, respectively, within the sample chamber.