Microwave frequency modulation of x-ray beam for radio therapy treatment system

• US 5,044,006 A
• Filed: 04/27/1990
• Issued: 08/27/1991
• Est. Priority Date: 04/27/1990
• Status: Expired due to Term

• Current Assignee: Reuven A. Cyrulnik
• Original Assignee: Reuven A. Cyrulnik
• Inventors: Cyrulnik, Reuven A.
• Primary Examiner(s): Westin, Edward P.
• Assistant Examiner(s): CHU, KIM KWOK
• Application Number:
  US07/515,192
• Time in Patent Office: 487 Days
• Field of Search: 378/64, 378/65, 378/113, 378/138, 378/145, 128/422, 128/364, 128/736, 128/664, 128/665, 600/1, 600/2
• US Class Current: 378/145
• CPC Class Codes: A61N 5/10 X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy A61N5/01 takes precedence
• CPC Class Codes: G21K 1/00 Arrangements for handling particles or ionising radiation, e.g. focusing or moderating production or acceleration of neutrons, electrically-charged particles, neutral molecular beams or neutral atomic beams H05H3/00 - H05H15/00
• CPC Class Codes: G21K 5/02 having no beam-forming means

Abstract

Radiation of specific material within a subject is accomplished by use of a beam of x-radiation modulated at a microwave frequency. The beam with its modulation is directed at the subject wherein the material interacts with the beam to extract a portion of the radiant energy carried by the beam. In the interaction, an electric field at the modulating frequency appears at the material. By selecting the modulated frequency equal to a resonant interactive microwave frequency of the material, a photon at the microwave frequency is absorbed by the material to alter its physical and chemical properties. By way of example, the material may be an oncogene or virus having a macromolecule and constituting a malignancy within a living subject. Absorption of the modulated radiation selectively destroys the malignancy. The klystron is disposed along the path of an electron beam in an x-ray source for modulating the electron beam and the resulting x-ray beam. An array of x-ray sources and detectors is arranged symmetrically about a site of the subject. Sequential activation of the x-ray sources along with a scanning of the microwave modulating frequency permits measurement of absorption of radiant energy at the various modulation frequencies. This information is used to select the appropriate modulation frequency.

Claims

1. A radio therapy treatment system for radiating a subject comprising:

means for generating an x-ray beam; and

amplitude modulation means operative with said generating means for providing amplitude modulation of the x-ray beam at a predetermined microwave frequency.

2. A system according to claim 1 further comprising selecting means including means operatively coupled to said modulation means for selecting a value of microwave modulation frequency equal to a resonant interactive frequency of material within the subject for absorption of radiant energy from the beam by the material.

3. A system according to claim 2 wherein said selecting means includes means for scanning the frequency of modulation, the system further comprising:

means for detecting radiation propagating through the subject, the detecting means signaling absorption and presence of radiant energy; and

means coupled to said detecting means for recording a frequency at which radiant energy is absorbed.

4. A system according to claim 3 wherein said x-ray generating means comprises:

a target and an electron gun for generating a beam of electrons impinging on said target; and

a klystron disposed along a path of travel of the electrons for modulating an electric field of said gun, the modulating of the electric field producing a bunching of electrons resulting in amplitude modulation of the x-ray beam.

5. A system according to claim 4 further comprising:

additional ones of said x-ray generating means, said first-mentioned generating means and said additional generating means constituting a plurality of generating means;

additional ones of said detecting means, said first-mentioned detecting means and said additional detecting means constituting a plurality of detecting means; and

wherein said plurality of generating means and said plurality of detecting means are distributed symmetrically about a site of the subject, the system further comprising means for sequentially activating said generating means.

6. A system according to claim 1 wherein said modulation of the x-ray beam provides a train of pulses of x-radiation.

7. A method of radio therapy treatment by radiating a subject with radiant energy at a resonant frequency for interaction with selected material of the subject comprising steps of:

amplitude modulating an x-ray beam with an amplitude modulating signal at a predetermined microwave frequency;

directing said beam upon the subject;

sweeping the modulating microwave frequency;

detecting radiant energy of said beam after passing of said beam through the subject;

determining a microwave frequency at which absorption of radiant energy of said beam occurs in the subject;

amplitude modulating said beam at a microwave frequency at which absorption occurs; and

radiating the subject with the beam, the beam being modulated at the absorption microwave frequency.

8. A method of radio therapy treatment by selective irradiation of pathological material in situ, comprising the steps of:

amplitude modulating an x-ray beam with an amplitude modulating signal, the modulating signal being at the microwave frequency of selective absorption of radiant energy by the selected pathological material; and

irradiating the pathological material with the modulated beam, whereby the selected pathological material absorbs the radiant energy of the beam.

9. The method of claim 8;

pathological material consists of malignant cells or part thereof.

10. The method of claim 8, wherein the selected pathological material consists of viruses or part thereof.

11. The method of claim 8, wherein the selected pathological material consists of macromolecules.

12. The method of claim 8, and further comprising the step of positionally directing the beam to a specific region of the pathological material.

13. The method of claim 8, further comprising the steps of:

modulating the x-ray beam with said modulating signal;

directing said beam upon the pathological material;

sweeping the modulating frequency;

detecting radiant energy of said beam after passing of said beam through the selected pathological material; and

using the detected frequency to modulate the beam for said irradiating step.

14. The method of claim 13, wherein said modulating signal is within the microwave range of frequencies.