Sensor assembly for measuring analytes in fluids

• US 5,046,496 A
• Filed: 04/26/1989
• Issued: 09/10/1991
• Est. Priority Date: 04/26/1989
• Status: Expired due to Fees

• Current Assignee: Radiometer California, Inc.
• Original Assignee: PPG Industries Incorporated (Nouryon BV)
• Inventors: Betts, Ronald E., Deetz, David W.
• Primary Examiner(s): Cohen, Lee S.
• Application Number:
  US07/343,234
• Time in Patent Office: 867 Days
• Field of Search: 128/635, 128/763, 128/767, 128/653, 204/403, 204/409, 525/524
• US Class Current: 600/352
• CPC Class Codes: G01N 2035/1062 for testing the liquid while it is in the transfer device
• CPC Class Codes: G01N 33/4925 measuring blood gas content, e.g. O2, CO2 , HCO3

Abstract

A sensor assembly for measuring analytes in fluids, e.g., blood, is described. The sensor assembly comprises a housing in the form of a flow-through cell containing one or more microsensors the housing disposed on the distal end of a hypodermic syringe.

Claims

1. Sensor assembly for measuring analytes in fluids comprising:

a syringe having a body portion with a piston slidable therein, said syringe having a distal end with an outlet port formed therein;

a housing that is a flow through cell having a proximate end with a port formed therein and a distal end with another port formed therein, where the proximate end of the housing engages with and connects to the distal end of the syringe so that a sample of fluid can be drawn through the housing by the syringe, the distal end of the housing adapted for engagement with means for withdrawing a sample of fluid;

sensing means disposed within said housing as an electrode assembly having at least one microsensor prepared by thick film processing for sensing at least one analyte in the sample of fluid including means for connecting said sensing means into a circuit and transmitting a signal to monitor means which measures and displays the value of the analyte sensed by the sensing means.

2. The sensor assembly of claim 1 wherein the fluid is blood and the distal end of the housing has a means for engagement through the other part with the means for withdrawing blood sample that is a hypodermic needle or an arterial catheter.

3. The sensor assembly of claim 1 wherein the sensing means has an electrode assembly that enables sensing of pH, PCO₂, and pO₂.

4. The sensor assembly of claim 1, wherein the electrode assembly of the sensing means is comprised of a ceramic substrate disposed within an coplanar with said housing, the substrate having formed thereon at least one thick film microsensor means for sensing at least one blood analyte.

5. The sensor assembly of claim 4 wherein the substrate has formed thereon three microsensor means for respectively sensing pH, pCO₂, and pO₂.

6. The sensor assembly of claim 5, wherein the electrode assembly of the sensing means has electric connectors and the sensing means includes a mating connector for the electric connectors of the electrode assembly and includes a cable connected to the mating connector.

7. The sensor assembly of claim 4, wherein the sensing means includes a heater and temperature sensing thermistor integrated onto the ceramic substrate with the at least one thick film microsensor means.

8. The sensor assembly of claim 1 wherein the syringe and associated piston and the housing are formed of plastic material.

9. The sensor assembly of claim 8 wherein the plastic material is polypropylene.

10. The sensor assembly of claim 1 wherein the sensing means are in direct contact with the fluid that is measured for analytes.

11. The sensor assembly of claim 1 wherein the sensing means includes a heater.

12. The sensor assembly of claim 1 wherein the sensing means includes a temperature sensing thermistor.

13. The sensor assembly of claim 1 that includes a means for withdrawing connected to the distal end of the housing and wherein the means for withdrawing and the distal and proximate ends of the housing and the distal end of the syringe are in alignment.

14. The sensor assembly of claim 1 wherein the electrode assembly is a ceramic substrate with a plurality of thick film microsensors.