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Method and apparatus for pulsed iontophoretic drug delivery

  • US 5,047,007 A
  • Filed: 12/22/1989
  • Issued: 09/10/1991
  • Est. Priority Date: 12/22/1989
  • Status: Expired due to Term
First Claim
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1. In a method of pulsed iontophoretic drug therapy, of the type wherein periodic electrical pulses are generated and applied to drive an active electrode and an indifferent electrode of an iontophoresis device in contact with the skin of a living body to deliver drug therethrough, an improvement comprising:

  • generating a train of said periodic pulses at a predetermined frequency, each pulse thereof extending over a first interval of time which defines a predetermined pulse width of said pulse, each pulse thereof being separated from a subsequent pulse by a second interval of time which defines a pulse interval which immediately follows said pulse width, the summation of said pulse width and immediately following pulse interval comprising a cycle period which is the reciprocal of said frequency, wherein each pulse has waveform characteristics, comprising;

    a first pulse segment extending over a predetermined first portion of said pulse width and having a predetermined first average current amplitude; and

    a second pulse segment extending over a subsequent second portion comprising the remainder of said pulse width and having a predetermined second average current amplitude;

    wherein said first average current amplitude is greater than said second average current amplitude and said second average current amplitude is greater than an average current amplitude during the pulse interval; and

    wherein said first portion comprises not more than 50% of said pulse width.

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