Pharmaceutical composition using albumin as a carrier and process for producing the same
First Claim
1. A process for producing a pharmaceutical composition comprising mixing together at high speed in a solvent 1 to 250 parts by weight of a drug capable of binding to protein and 100 parts by weight of albumin, and thereafter(2) removing the solvent, wherein the drug is nifedipine, aspirin, nalidixic acid, piroxicam, sulindac, phenylbutazone, cefaclor, cefalexin, tetracycline hydrochloride, ampicillin, dexamethasone, dlα
- -tocopherol, haloperidol, diltazem hydrochloride, defalexin, griseofulvin, vincristine sulfate, cimetidine, ketotifen, glycyrrhizin or tranilast.
1 Assignment
0 Petitions
Accused Products
Abstract
The pharmaceutical composition of the present invention is a pharmaceutical composition of high drug content containing 1-200 parts by weight of a drug having a protein binding property and 100 parts by weight of albumin.
This pharmaceutical composition is produced by stirring the drug and albumin of the above proportions at a high speed in an aqueous solvent and then removing the solvent by distillation, and has effects of alleviating the side effect of the drug used therein and also of improving the absorption, light stability, etc. of the drug.
60 Citations
6 Claims
-
1. A process for producing a pharmaceutical composition comprising mixing together at high speed in a solvent 1 to 250 parts by weight of a drug capable of binding to protein and 100 parts by weight of albumin, and thereafter
(2) removing the solvent, wherein the drug is nifedipine, aspirin, nalidixic acid, piroxicam, sulindac, phenylbutazone, cefaclor, cefalexin, tetracycline hydrochloride, ampicillin, dexamethasone, dlα - -tocopherol, haloperidol, diltazem hydrochloride, defalexin, griseofulvin, vincristine sulfate, cimetidine, ketotifen, glycyrrhizin or tranilast.
- View Dependent Claims (2, 3, 4, 5, 6)
Specification