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Crosslinked hydrogel and method for making same

  • US 5,069,908 A
  • Filed: 06/06/1990
  • Issued: 12/03/1991
  • Est. Priority Date: 06/19/1989
  • Status: Expired due to Term
First Claim
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1. A crosslinked hydrogel for use in transcutaneous electrical nerve stimulation and iontophoresis to provide transdermal delivery of an active ingredient comprising:

  • (a) an active ingredient selected from the class of lidocainehydrochloride, hydrocortisone, menthol or methyl salicylate;

    (b) a crosslinking agent, aluminum acetate in a quantity of about 0.1% to about 0.5% by weight to provide ionic conductivity in said hydrogel;

    (c) water;

    (d) an emulsifier selected from the class of propyleneglycol, lanolin, stearic acid or ethyl alcohol; and

    (e) carboxymethylcellulose in an amount of between 1.1% to 1.7% by weight, wherein said hydrogel is characterized by having an electrical resistance of less than 10,000 ohms per linear centimeter.

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