Sensor with overcoating and process for making same

• US 5,075,127 A
• Filed: 03/12/1990
• Issued: 12/24/1991
• Est. Priority Date: 10/10/1986
• Status: Expired due to Term

• Current Assignee: Terumo Cardiovascular Systems Corporation (Terumo Corporation)
• Original Assignee: 3M Company
• Inventors: Hui, Henry K., Yafuso, Masao, Yan, Cheng F., Miller, William W.
• Primary Examiner(s): Bell, Janyce
• Application Number:
  US07/492,550
• Time in Patent Office: 652 Days
• Field of Search: 427/163, 427/164, 427/165, 427/169, 427/2, 427/339
• US Class Current: 427/2.11
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: G01N 2021/6434 Optrodes
• CPC Class Codes: G01N 2021/772 Tip coated light guide
• CPC Class Codes: G01N 21/6428 Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" in vivo A61B5/00; immunoassay G01N33/53
• CPC Class Codes: G01N 21/7703 using reagent-clad optical fibres or optical waveguides using measurement of total internal reflection or attenuated total reflection G01N21/552; optical fibres or waveguides per se G02B
• CPC Class Codes: G01N 21/81 Indicating humidity
• CPC Class Codes: G01N 31/223 for investigating presence of specific gases or aerosols G01N31/221, G01N31/222 take precedence; actuation of fire alarm by presence of smoke or gases G08B17/10

Abstract

A sensor comprising a sensing element capable of sensing a component in an aqueous medium and an overcoating at least partially covering the sensing element. The overcoating comprises a water insoluble, component permeable, cross-linked cellulosic material and an effective amount of an opaque agent.

Claims

1. A process for forming an overcoating on a sensing element, comprising the steps of:

contacting a sensing element with a composition comprising a solvent and a soluble cellulosic coating material or a soluble precursor of said cellulosic coating material to form a composition coated sensing element; and

treating said composition coated sensing element so as to cross-link said cellulosic coating material and form said overcoating on said sensing element.

2. The process of claim 1 wherein said composition and thus said overcoating includes an opaque agent.

3. The process of claim 1 further comprising the step of contacting said sensing element with an opaque agent to at least partially coat said sensing element with said opaque agent prior to contacting said sensing element with said composition.

4. The process of claim 2 wherein said composition further includes an additional component in an amount effective to enhance the permeability of said overcoating to an analyte to be sensed.

5. The process of claim 1 wherein said composition includes acylated cellulose as a soluble precursor of said cellulosic coating material.

6. The process of claim 1 wherein said treating step acts to both hydrolyze the cellulosic material or precursor and cross-link the hydrolyzed material to form said cross-linked cellulosic coating material-containing overcoating.

7. The process of claim 1 which further comprises the step of forming a blood compatible film on said overcoating.

8. The process of claim 2 wherein said opaque agent is a dye adsorptive opaque agent.

9. The process of claim 8 wherein said dye adsorptive opaque agent is carbon black.

10. The process of claim 4 wherein said additional component is substantially removed from said composition coated sensing element during said treating step.

11. The process of claim 10 wherein said additional component is water soluble and said treating step comprises contacting said sensing element containing said cross-linked cellulosic coating material with an aqueous liquid at conditions effective to substantially remove said additional component.

12. The process of claim 11 wherein said treating step comprises both contacting said composition coated sensing element at conditions effective to hydrolyze at least a portion of said cellulosic coating material on said sensing element, and contacting said sensing element containing said hydrolyzed cellulosic material with at least one cross-linking agent at conditions effective to form said cross-linked cellulosic coating material on said sensing element.

13. The process of claim 1 wherein said treating step comprises both contacting said composition coated sensing element at conditions effective to hydrolyze at least a portion of said cellulosic coating material on said sensing element, and contacting said sensing element containing said hydrolyzed cellulosic material with at least one cross-linking agent at conditions effective to form said cross-linked cellulosic coating material on said sensing element.

14. The process of claim 13 wherein said cross-linking agent is selected from the group consisting of ethylene glycol diglycidyl ether, butanediol diglycidyl ether, epichlorohydrine, 1,3 butadiene diepoxide, 1,2,7,8-diepoxy octane, 1,2,5,6-diepoxy cyclooctane, diethylene glycol diglycidyl ether, and mixtures thereof.

15. The process of claim 13 wherein said cross-linking agent is ethylene glycol diglycidyl ether.

16. The process of claim 1 wherein said composition includes a soluble precursor of said cellulosic coating material, said precursor comprising acylated cellulose wherein the acyl groups contain about 1 to about 10 carbon atoms per molecule.

17. The process of claim 1 wherein said composition includes a soluble precursor of said cellulosic coating material and wherein said precursor is cellulose acetate.

18. The process of claim 2 wherein said opaque agent is a dye non-adsorptive opaque agent.

19. The process of claim 18 wherein said dye non-adsorptive opaque agent is selected from the group consisting of ferric oxide, metallic phthalocyanines, and mixtures thereof.

20. The process of claim 19 wherein said dye non-adsorptive opaque agent is a metallic phthalocyanine and wherein the metallic portion of said phthalocyanine is selected from the group of metals consisting of copper, iron, cobalt, lithium, magnesium, nickel, zinc, vanadium, manganese, sodium, and mixtures thereof.