Method and apparatus for breast imaging and tumor detection using modal vibration analysis

• US 5,099,848 A
• Filed: 11/02/1990
• Issued: 03/31/1992
• Est. Priority Date: 11/02/1990
• Status: Expired due to Term

• Current Assignee: University of Rochester
• Original Assignee: University of Rochester
• Inventors: Parker, Kevin J., Huang, Sung-Rung, Lerner, Robert M.
• Primary Examiner(s): Jaworski, Francis
• Assistant Examiner(s): MANUEL, GEORGE C
• Application Number:
  US07/608,391
• Time in Patent Office: 515 Days
• Field of Search: 128/660.01, 128/660.05, 128/661.09, 128/774, 128/661.07, 73/575
• US Class Current: 600/443
• CPC Class Codes: A61B 5/0051 by applying vibrations
• CPC Class Codes: A61B 8/0825 for diagnosis of the breast, e.g. mammography
• CPC Class Codes: A61B 8/485 involving measuring strain or elastic properties
• CPC Class Codes: G01S 15/895 characterised by the transmitted frequency spectrum
• CPC Class Codes: G01S 15/8979 Combined Doppler and pulse-echo imaging systems
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

A system for using Doppler modulation parameters for producing an estimation of the vibration amplitude of an object under investigation is disclosed in which a low frequency vibration source is used to force the oscillation of the object under investigation and a coherent or pulsed ultrasound imaging system is utilized to detect the spatial distribution of the vibration amplitude of the object in real-time. The reflected Doppler shifted waveform generated by reflecting the ultrasound waves off of the vibrating object under investigation is used to compute the vibration amplitude and frequency of the object using two alternative methods, either on a frequency domain estimator basis or on a time domain estimator basis. The system may also be utilized for breast imaging and tumor detection. By conforming the breast to a regular geometry, exciting specific vibrational eigenmodes, and analyzing the Doppler modulation parameters, the inherent shear and longitudinal wave parameters of breast tissue can be calculated. These are useful for detection of tumors and other abnormalities.

Claims

1. A method for determining the elastic constants of breast tissue in order to detect the presence of tumors or other abnormalities in said tissue using Doppler shifted signals reflected from said breast tissue, comprising the steps of:

conforming the breast tissue to a predetermined regular geometry;

exciting specific vibrational eigenmodes in said breast tissue;

scanning said breast tissue with coherent radiation and receiving Doppler shifted signals reflected by said breast tissue; and

analyzing said Doppler shifted signals to derive the vibration amplitude of said breast tissue.

2. The method of claim 1, wherein said step of analyzing includes analyzing an image created by exciting said specific vibrational eigenmodes in said breast tissue.

3. The method of claim 2, wherein said image has dominant pattern spacing at the wavelengths of said vibrational eigenmodes.

4. The method of claim 1, wherein said step of scanning uses pulsed coherent radiation.

5. The method of claim 1, wherein said step of analyzing comprises forming an image of the vibration amplitude within said conformed breast tissue and analyzing said image with respect to said specific vibrational eigenmodes in said breast tissue.

6. The method of claim 1, wherein said coherent radiation is pulsed electromagnetic radiation.

7. The method of claim 1, wherein said coherent radiation is acoustic radiation.

8. A method for characterizing breast tissue by modal vibration analysis in real-time, using Doppler shifted signals reflected from said breast tissue, comprising the steps of:

conforming said breast tissue to a predetermined regular geometry;

vibrating said conformed breast tissue using a source of vibration;

impinging coherent radiation on the surface of said conformed breast tissue;

receiving said Doppler shifted signals reflected from said surface of breast tissue; and

analyzing said Doppler shifted signals to determine discrete eigenmodes and eigenfrequencies.

9. The method of claim 8, further including the step of scanning the surface of said object with said impinging coherent radiation.

10. The method of claim 8, wherein said source of vibration has a frequency of approximately 1-1000 Hertz.

11. The method of claim 8, wherein said step of analyzing is accomplished using a time domain estimator system.

12. The method of claim 8, wherein said step of analyzing is accomplished using a frequency domain estimator system.

13. The method of claim 8, wherein said step of analyzing comprises the steps of:

generating quadrature phase signals representative of said Doppler shifted signals;

deriving the phase and co-phase signals of said quadrature phase signals; and

calculating the vibration amplitude of said conformed breast tissue based upon said quadrature phase, phase and co-phase signals.

14. The method of claim 8, wherein said coherent radiation is pulsed electromagnetic radiation.

15. The method of claim 8, wherein said coherent radiation is acoustic radiation.

16. The method of claim 8, wherein said source of vibration produces one of pure tone and broad band signals.

17. A method for determining the elastic constants of soft tissue in order to detect the presence of tumors or other abnormalities in said tissue using Doppler shifted signals reflected from said soft tissue, comprising the steps of:

conforming the soft tissue to a predetermined regular geometry;

exciting specific vibrational eigenmodes in said soft tissue;

scanning said soft tissue with coherent radiation and receiving Doppler shifted signals reflected by said soft tissue; and

analyzing said Doppler shifted signals to derive the vibration amplitude of said soft tissue.

18. The method of claim 17, wherein said step of analyzing includes analyzing an image created by exciting said specific vibrational eigenmodes in said soft tissue.

19. The method of claim 18, wherein said image has dominant pattern spacing at the wavelengths of said vibrational eigenmodes.

20. The method of claim 17, wherein said step of analyzing comprises forming an image of the vibration amplitude within said conformed soft tissue and analyzing said image with respect to said specific vibrational eigenmodes in said soft tissue.

21. The method of claim 17, wherein said step of scanning used pulsed content radiation.

22. The method of claim 17, wherein the step of analyzing comprises forming an image of the vibration amplitude within said conformed soft tissue and analyzing said image with respect to said specific vibrational eigenmodes in said soft tissue.

23. A method for characterizing soft tissue by modal vibration analysis in real-time, using Doppler shifted signals reflected from said soft tissue, comprising the steps of:

conforming said soft tissue to a predetermined regular geometry;

vibrating said conformed soft tissue using a source of vibration;

impinging coherent radiation on the surface of said conformed soft tissue;

receiving said doppler shifted signals reflected from said surface of soft tissue; and

analyzing said doppler shifted signals to determine discrete eigenmodes and eigenfrequencies.

24. The method of claim 23, further including the step of scanning the surface of said soft tissue with said impinging coherent radiation.

25. The method of claim 23, wherein said source of vibration has a frequency of approximately 1-1000 Hertz.

26. The method of claim 23, wherein said step of analyzing is accomplished using a time domain estimator system.

27. The method of claim 23, wherein said step of analyzing is accomplished using a frequency domain estimator system.

28. The method of claim 23, wherein said step of analyzing comprises the steps of:

generating quadrature phase signals representative of said Doppler shifted signals;

deriving the phase and co-phase signals of said quadrature phase signals; and

calculating the vibration amplitude of said conformed soft tissue based upon said quadrature phase, phase and co-phase signals.

29. The method of claim 23, wherein said coherent radiation is pulsed electromagnetic radiation.

30. The method of claim 23, wherein said source of vibration produces one of pure tone and broadband signals.

31. A system for characterizing breast tissue, comprising:

means for conforming said breast tissue into a predetermined geometry;

a vibration source for exciting vibrational eigenmodes in said breast tissue;

a pulsed coherent energy imaging system for scanning said breast tissue and for receiving Doppler shifted signals representative of said vibrational eigenmodes reflected by said breast tissue resulting from said scanning; and

means for evaluating said vibrational eigenmodes occurring within said breast tissue.

32. The system of claim 31, wherein said vibration source produces one of pure tone and broadband signals.