Method for noninvasive intermittent and/or continuous hemoglobin, arterial oxygen content, and hematocrit determination
First Claim
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1. A method for noninvasively determining one or more of the following blood parameters:
- total hemoglobin, arterial oxygen content, and hematocrit, in an animal or human;
said method comprising one or more of the following;
(a) measuring changes in the mass of total hemoglobin in a specified portion of said human or animal, as a function of changes in blood volume in said specified portion of said animal or human to obtain a value for Δ
THb/Δ
V and calculating at least one of the above parameters using known relationships between Δ
THb/Δ
V and the parameter of interest;
(b) measuring changes in mass of oxyhemoglobin in a specified portion of said animal or human as a function of changes in blood volume in said specified portion of said animal or human to obtain a value for Δ
HbO2/Δ
V and calculating at least one of the above parameters using known relationships between Δ
HbO2/Δ
V and the parameter of interest; and
(c) measuring changes in mass of reduced hemoglobin in a specified portion of said animal or human as a function of changes in blood volume in said specified portion of said animal or human to obtain a value for Δ
RHb/Δ
V and calculating at least one of the above parameters using known relationships between Δ
RHb/Δ
V and the parameter of interest.
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Abstract
Described here are a novel means and device for noninvasively quantifying important blood constituents. Total hemoglobin, arterial oxygen content, hematocrit, and other parameters can all be determined quickly and easily without the need for skin puncture or lengthy laboratory analysis. The invention described here concerns the simultaneous measurement of volume changes and changes in the mass of either oxyhemoglobin, total hemoglobin, or reduced hemoglobin. The data obtained by these measurements is used to quantify the parameters of interest.
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14 Claims
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1. A method for noninvasively determining one or more of the following blood parameters:
- total hemoglobin, arterial oxygen content, and hematocrit, in an animal or human;
said method comprising one or more of the following;(a) measuring changes in the mass of total hemoglobin in a specified portion of said human or animal, as a function of changes in blood volume in said specified portion of said animal or human to obtain a value for Δ
THb/Δ
V and calculating at least one of the above parameters using known relationships between Δ
THb/Δ
V and the parameter of interest;(b) measuring changes in mass of oxyhemoglobin in a specified portion of said animal or human as a function of changes in blood volume in said specified portion of said animal or human to obtain a value for Δ
HbO2/Δ
V and calculating at least one of the above parameters using known relationships between Δ
HbO2/Δ
V and the parameter of interest; and(c) measuring changes in mass of reduced hemoglobin in a specified portion of said animal or human as a function of changes in blood volume in said specified portion of said animal or human to obtain a value for Δ
RHb/Δ
V and calculating at least one of the above parameters using known relationships between Δ
RHb/Δ
V and the parameter of interest. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
- total hemoglobin, arterial oxygen content, and hematocrit, in an animal or human;
Specification