Method of treating protozoal gastrointestinal disorders by administering hyperimmune milk product

  • US 5,106,618 A
  • Filed: 05/22/1989
  • Issued: 04/21/1992
  • Est. Priority Date: 07/02/1987
  • Status: Expired due to Term
First Claim
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1. A method of treating cryptosporidiosis or isosporiasis in an immunocompromised animal which comprises:

  • administering to said immunocompromised animal a hyperimmune milk product containing a biologically active component which reduces the number of oocysts in the stool, reduces the number of Cryptosporidia or Isospora parasites in the intestine or alleviates the symptoms of cryptosporidiosis or isosporiasis in a subject infected with Cryptosporidia or Isospora from a hyperimmunized milk-producing mammal selected from the group consisting of cows, sheep, and goats, in amounts sufficient to treat said cryptosporidiosis or isosporiasis, wherein said hyperimmune milk product is selected from the group consisting of hyperimmune whole milk, hyperimmune whole milk fractions, and derivatives of hyperimmune whole milk which contain said biologically active component and is prepared by a process comprising;

    (i) hyperimmunizing said milk-producing mammal with a mixture of non-protozoan bacterial antigens;

    (ii) collecting milk from said milk-producing mammal after said milk-producing mammal reaches a hyperimmune state;

    (iii) filtering said milk through a molecular sieve which excludes proteins of molecular weight greater than 100,000 daltons; and

    (iv) testing the retentate of step (iii) for its ability to reduce the number of oocysts in the stool, reduce the number of Cryptosporidia or Isospora parasites in the intestine or alleviate symptoms of cryptosporidiosis or isosporiasis in a subject infected with Cryptosporidia or Isospora by administering to said subject the retentate of step (iii) and measuring the reduction of said oocysts, parasites, or symptoms.

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