Dispensing devices powered by lyotropic liquid crystals

• US 5,108,756 A
• Filed: 11/08/1990
• Issued: 04/28/1992
• Est. Priority Date: 01/12/1989
• Status: Expired due to Fees

• Current Assignee: Pfizer Inc.
• Original Assignee: Pfizer Inc.
• Inventors: Curatolo, William J.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): MCPHAIL, DONALD
• Application Number:
  US07/611,212
• Time in Patent Office: 537 Days
• Field of Search: 424/450, 424/457, 424/468, 424/473, 424/420, 424/467, 424/438, 604/892.1
• US Class Current: 424/450
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

This invention relates to devices useful for the controlled delivery of one or more beneficial agents to an environment of use. More specifically, this invention concerns such devices which are powered by lyotropic liquid crystals. This invention also relates to the controlled delivery of one or more beneficial agents to an aqueous environment of use through the use of such lyotropic liquid crystal powered dispensing devices. Also disclosed are methods for the controlled delivery of one or more beneficial agents to an aqueous environment of use which comprise administering to or otherwise placing the devices of this invention in the environment of use.

Claims

1. A dispensing device which comprises:

(a) a mixture comprising a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and

(b) a coating containing a plurality of pores which coating surrounds the mixture.

2. The dispensing device according to claim 1 wherein the beneficial agent is a drug.

3. The dispensing device according to claim 2 wherein the lyotropic liquid crystal is a phospholipid.

4. The dispensing device according to claim 3 wherein the coating comprises cellulose acetate.

5. The dispensing device according to claim 2 wherein the lyotropic liquid crystal is a salt of a fatty acid and the coating comprises cellulose acetate.

6. The dispensing device according to claim 2 wherein the lyotropic liquid crystal comprises a mixture of a phospholipid and a salt of a fatty acid and the coating comprises cellulose acetate.

7. The dispensing device according to claim 1 wherein the mixture additionally comprises an osmotically effective solute.

40. A method for the controlled delivery of one or more beneficial agents to an environment of use which comprises placing the device of claim 1 into the environment of use.

8. A dispensing device which comprises:

(a) a mixture comprising a beneficial agents and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and

(b) a coating which surrounds the mixture and which comprises a polymer and one or more porosigens.

9. The dispensing device according to claim 8 wherein the beneficial agent is a drug.

10. The dispensing device according to claim 8 wherein the lyotropic liquid crystal is a phospholipid.

11. The dispensing device according to claim 10 wherein the coating polymer is cellulose acetate.

12. The dispensing device according to claim 11 wherein the porosigen is one or more water soluble polymers.

13. The dispensing device according to claim 12 wherein the water soluble polymer is selected from the group consisting of hydroxypropyl cellulose, polyethylene glycol and polyethylene oxide.

14. The dispensing device according to claim 11 wherein the porosigens are one or more water soluble polymers and one or more inorganic salts.

15. The dispensing device according to claim 11 wherein the porosigens are one or more water soluble polymers and one or more water soluble particulate organic compounds and the salts thereof.

16. The dispensing device according to claim 15 wherein the water soluble polymer is polyethylene glycol-600 and the water soluble particulate organic compound is sucrose.

17. The dispensing device according to claim 11 wherein the porosigen is one or more inorganic salts or one or more water soluble particulate organic compounds and salts thereof.

18. The dispensing device according to claim 9 wherein the lyotropic liquid crystal is a salt of a fatty acid and the coating comprises cellulose acetate.

19. The dispensing device according to claim 9 wherein the lyotropic liquid crystal comprises a mixture of a phospholipid and a salt of a fatty acid and the coating comprises cellulose acetate.

20. The dispensing device according to claim 8 wherein the mixture additionally comprises an osmotically effective solute.

41. A method for the controlled delivery of one or more beneficial agents to an environment of use which comprises placing the device of claim 8 into the environment of use.

46. A method for the controlled delivery of a drug to an animal which comprises administering to the animal the device according to claim 8 wherein the beneficial agent is a drug.

21. A dispensing device which comprises:

(a) a first layer comprising a mixture of a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and

(b) a second layer comprising a lyotropic liquid crystal which second layer is adjacent to the first layer and comprises an area in contact with the first layer; and

(c) a coating containing at least one hole adjacent to the first layer which coating surrounds the first and second layers except for said area in contact.

22. The dispensing device according to claim 21 wherein the first layer additionally comprises an osmotically effective solute.

23. The dispensing device according to claim 21 wherein the second layer additionally comprises an osmotically effective solute.

24. The dispensing device according to claim 21 wherein the first and second layers each additionally comprise an osmotically effective solute.

25. The dispensing device according to claim 21 wherein the coating containing at least one hole comprises a polymer and one or more porosigens.

42. A method for the controlled delivery of one or more beneficial agents to an environment of use which comprises placing the device of claim 21 into the environment of use.

26. A dispensing device which comprises:

(a) a mixture comprising a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and

(b) a coating containing a least one hole which coating surrounds the mixture.

27. The dispensing device according to claim 26 wherein the beneficial agent is a drug.

28. The dispensing device according to claim 27 wherein the lyotropic liquid crystal is a phospholipid.

29. The dispensing device according to claim 28 wherein the coating comprises cellulose acetate.

30. The dispensing device according to claim 26 wherein the mixture additionally comprises an osmotically effective solute.

31. The dispensing device according to claim 26 wherein at least one hole passes through the device.

43. A method for the controlled delivery of one or more beneficial agents to an environment of use which comprises placing the device of claim 26 into the environment of use.

32. A dispensing device which comprises:

(a) a first layer comprising a mixture of a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and

(b) a second layer comprising a lyotropic liquid crystal which second layer is adjacent to the first layer and comprising an area in contact with the first layer; and

(c) a coating containing a plurality of pores which coating surrounds the first and second layers except for said area in contact.

33. The dispensing device according to claim 32 wherein the first layer additionally comprises an osmotically effective solute.

34. The dispensing device according to claim 32 wherein the second layer additionally comprises an osmotically effective solute.

35. The dispensing device according to claim 32 wherein the first and second layers each additionally comprise an osmotically effective solute.

44. A method for the controlled delivery of one or more beneficial agents to an environment of use which comprises placing the device of claim 32 into the environment of use.

36. A dispensing device which comprises:

(a) a first layer comprising a mixture of a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and

(b) a second layer comprising a lyotropic liquid crystal which second layer is adjacent to the first layer and comprises an area in contact with the first layer; and

(c) a coating which surrounds the first and second layers except for said area in contact and which comprises a polymer and one or more porosigens.

37. The dispensing device according to claim 36 wherein the first layer additionally comprises an osmotically effective solute.

38. The dispensing device according to claim 36 wherein the second layer additionally comprises an osmotically effective solute.

39. The dispensing device according to claim 36 wherein the first and second layers each additionally comprise an osmotically effective solute.

45. A method for the controlled delivery of one or more beneficial agents to an environment of use which comprises placing the device of claim 36 into the environment of use.