Dibenz[b,e]oxepin derivative and pharmaceutical compositions thereof

• US 5,116,863 A
• Filed: 03/02/1987
• Issued: 05/26/1992
• Est. Priority Date: 03/03/1986
• Status: Expired due to Term

• Current Assignee: Kyowa Hakko Kirin Company Limited (Kirin Holdings Company Limited)
• Original Assignee: Kyowa Hakko Kogyo Company Limited (Kirin Holdings Company Limited)
• Inventors: Otaki, Shizuo, Shuto, Katsuichi, Ohmori, Kenji, Tamura, Tadafumi, Manabe, Haruhiko, Kumazawa, Toshiaki, Ishii, Hidee, Obase, Hiroyuki, Oshima, Etsuo
• Primary Examiner(s): Raymond, Richard L.
• Application Number:
  US07/020,900
• Time in Patent Office: 1,912 Days
• Field of Search: 540/596, 540/602, 544/62, 544/137, 544/147, 544/369, 544/375, 544/98.7, 546/196, 548/215, 548/525, 549/354, 514/212, 514/222, 514/233, 514/234, 514/236, 514/237, 514/253, 514/320, 514/374, 514/422, 514/450, 514/228.2, 514/232.8
• US Class Current: 514/450
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: C07D 313/12 [b,e]-condensed
• CPC Class Codes: C07D 405/06 linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 405/12 linked by a chain containing hetero atoms as chain links

Abstract

Novel dibenz[b,e]oxepin derivatives are employed in the treatment and control of allergic conditions such as allergic asthma and also employed in the treatment of inflammation.

Claims

1. A dibenz[b,e]oxepin compound in cis form having the formula ##STR55## and pharmaceutically acceptable salts thereof.

2. A compound according to claim 1, wherein said salt is selected from the group consisting of acid addition salt, metal salt, ammonium salt, organic amine addition salt, and amino acid addition salt.

3. A pharmaceutical composition comprising a pharmaceutical carrier and as an active ingredient, an effective amount of a dibenz[b,e]oxepin compound defined in claim 1.