Method for treating acne vulgaris with a composition containing a stable, high purity, substantially anhydrous complex of PVP-H.sub.2 O.sub. 2

• US 5,122,370 A
• Filed: 05/20/1991
• Issued: 06/16/1992
• Est. Priority Date: 05/20/1991
• Status: Expired due to Term

• Current Assignee: ISP Capital, Inc. (Ashland Global Holdings, Inc.)
• Original Assignee: ISP Investments, Inc. (Ashland Global Holdings, Inc.)
• Inventors: Merianos, John J., Helioff, Michael W.
• Primary Examiner(s): Schenkman, Leonard
• Application Number:
  US07/702,546
• Time in Patent Office: 393 Days
• Field of Search: 424/80, 424/616
• US Class Current: 424/78.05
• CPC Class Codes: A61K 2800/31 Anhydrous
• CPC Class Codes: A61K 33/40 Peroxides
• CPC Class Codes: A61K 47/58 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
• CPC Class Codes: A61K 8/22 Peroxides; Oxygen; Ozone
• CPC Class Codes: A61K 8/8176 Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

What is provided herein is a method for treating acne vulgaris with a composition containing a stable, high purity, substantially anhydrous complex of PVP and H₂ O₂ in which the constituents are present respectively in substantially a 1:1 molar ratio and the complex is a free-flowing, fine white powder.

Claims

1. A composition for treating acne vulgaris consisting essentially of about 1 to 10% by weight of active H₂ O₂ provided by a stable, high purity, substantially anhydrous, 1:

1 molar ratio complex of PVP and H₂ O₂ in the form of a free-flowing, fine white powder in a non-aqueous, organic solvent.

2. A composition according to claim 1 which is a stick formulation which includes a base component therein.

3. A composition according to claim 2 wherein the complex and solvent, and base, are present in amounts of 40-60:

60-40, respectively.

4. A composition according to claim 1 wherein said organic solvent is ethanol, propylene glycol or glycerol.

5. A composition according to claim 4 wherein said complex to solvent weight ratio is about 60:

40, 50;

50 and 25-30;

70-75, respectively.

6. A method for treating acne vulgaris which comprises contacting living tissue affected with the composition of claim 1.

7. A method according to claim 6 wherein said active H₂ O₂ is present in said composition at about a 3 to 7% by weight level.

8. A method according to claim 6 wherein said composition is a stick formulation which includes a base component.

9. A method according to claim 8 wherein said complex in said non-aqueous, organic solvent, and said base component, are present in amount of 40-60:

60;

40, respectively.