Delivery device providing beneficial agent stability
First Claim
1. An improved fluid-imbibing delivery device for delivering a beneficial agent to a biological environment of use, the dispensing device having a housing which includes a fluid-impermeable first wall section with an open end and a fluid-permeable second wall section with an open end, an internal compartment formed by the first and second wall sections, exit means in the housing, a fluid-sensitive beneficial agent formulation in that portion of the compartment formed by the first wall section, expandable driving means in that portion of the compartment formed by the second wall section, and a partition layer between the beneficial agent formulation and the expandable driving means;
- wherein the improvement comprises the first wall section being comprised of an extremely fluid-impermeable material and the open end of each of the first wall section and the second wall section having reciprocally tapered edges one with the other to form a tapered lap joint for mating engagement, the tapered lap joints being bonded together with a pressure-sensitive contact adhesive to form the housing.
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Accused Products
Abstract
The present invention is directed to an improved fluid-imbibing dispensing device for delivering a beneficial agent to a biological environment of use, the dispensing device being of the type having a housing which includes a fluid-impermeable first wall section with an open end and a fluid-permeable second wall section with an open end, an internal compartment formed by the first and second wall sections, exit means in the housing, a beneficial agent in that portion of the compartment formed by the first wall section, expandable driving means in that portion of the compartment formed by the second wall section, and a partition layer between the beneficial agent and the expandable driving means; wherein the improvement comprises the first wall section being comprised of an extremely fluid-impermeable material and the open end of each of the first wall section and the second wall section having reciprocally tapered edges one with the other to form a tapered lap joint for mating engagement, the tapered lap joints being bonded together with a pressure-sensitive contact adhesive to form the housing.
352 Citations
22 Claims
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1. An improved fluid-imbibing delivery device for delivering a beneficial agent to a biological environment of use, the dispensing device having a housing which includes a fluid-impermeable first wall section with an open end and a fluid-permeable second wall section with an open end, an internal compartment formed by the first and second wall sections, exit means in the housing, a fluid-sensitive beneficial agent formulation in that portion of the compartment formed by the first wall section, expandable driving means in that portion of the compartment formed by the second wall section, and a partition layer between the beneficial agent formulation and the expandable driving means;
- wherein the improvement comprises the first wall section being comprised of an extremely fluid-impermeable material and the open end of each of the first wall section and the second wall section having reciprocally tapered edges one with the other to form a tapered lap joint for mating engagement, the tapered lap joints being bonded together with a pressure-sensitive contact adhesive to form the housing.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for delivering a fluid-sensitive beneficial agent to an animal, wherein the method comprises:
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(1) admitting into the animal an improved fluid-imbibing delivery device having a housing which includes a fluid-impermeable first wall section with an open end and a fluid-permeable second wall section with an open end, an internal compartment formed by the first and second wall sections, exit means in the housing, a fluid-sensitive beneficial agent formulation in that portion of the compartment formed by the first wall section, expandable driving means in that portion of the compartment formed by the second wall section, and a partition layer between the beneficial agent formulation and the expandable driving means;
wherein the improvement comprises the first wall section being comprised of an extremely fluid-impermeable material and the open end of each of the first wall section and the second wall section having reciprocally tapered edges one with the other to form a tapered lap joint for mating engagement, the tapered lap joints being bonded together with a pressure-sensitive contact adhesive to form the housing;(2) allowing fluid to be imbibed through the fluid-permeable second wall section of the dispenser for causing the expandable driving member to increase in volume; and (3) delivering beneficial agent to the animal by the driving member increasing in volume and occupying space in the internal compartment comprising the first wall section, thereby pushing the beneficial agent formulation through the exit means to the animal. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
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18. A method for providing improved stability for a fluid-sensitive beneficial agent formulation in a fluid environment of use, which method comprises:
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(1) admitting into the environment of use an improved fluid-imbibing delivery device having a housing which includes a fluid-impermeable first wall section with an open end and a fluid-permeable second wall section with an open end, an internal compartment formed by the first and second wall sections, exit means in the housing, a fluid-sensitive beneficial agent formulation in that portion of the compartment formed by the first wall section, expandable driving means in that portion of the compartment formed by the second wall section, and a partition layer between the beneficial agent formulation and the expandable driving means;
wherein the improvement comprises the first wall section being comprised of an extremely fluid-impermeable material and the open end of each of the first wall section and the second wall section having reciprocally tapered edges one with the other to form a tapered lap joint for mating engagement, the tapered lap joints being bonded together with a pressure-sensitive contact adhesive to form the housing;(2) allowing fluid to be imbibed through the fluid-permeable second wall section of the dispenser for causing the expandable driving member to increase in volume; and (3) delivering beneficial agent to the animal by the driving member increasing in volume and occupying space in the internal compartment comprising the first wall section, thereby pushing the beneficial agent formulation through the exit means to the animal. - View Dependent Claims (19, 20, 21, 22)
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Specification