Octahydroindole-2-carboxylic acids

  • US 5,162,362 A
  • Filed: 12/27/1983
  • Issued: 11/10/1992
  • Est. Priority Date: 08/30/1980
  • Status: Expired due to Term
First Claim
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1. A compound of the formulaor a physiologically tolerated salt thereof, wherein R1 is(a) (C1 -C6)-alkyl or(b) (C1 -C6)-alkyl substituted by(C5 -C7)-cycloalkylamino,(C1 -C6)-alkoxycarbonylamino,(C1 -C6)-alkanoylamino, or(C1 -C6)-alkoxyphenyl;

  • R2 is(a) (C1 -C6)-alkyl,(b) (C1 -C6)-alkyl substituted by1) (C5 -C7)-cycloalkyl,2) phenoxy,3) phenoxy substituted by3.1 halogen,3.2 methyl, or3.3 methoxy,4) amino,5) (C1 -C6)-alkylureido,6) cyclohexylureido,7) phenylureido,8)(C1 -C6)-alkylmercapto,(C1 -C6)-alkylsulfinyl, or(C1 -C6)-alkylsulfonyl,9) phenylmercapto, phenylsulfinyl, or phenylsulfonyl,10) benzylmercapto, benzylsulfinyl, or benzylsulfonyl,11) a heterocycle selected from the group consisting of indole, imidazole, pyrrole, pyrazole, thiophene, thiazole, or12) such a heterocycle substituted by12.1 halogen,12.2 methyl, or12.3 amino; and

    wherein R3 is hydrogen, (C1 -C6)-alkyl, or benzyl.

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