Solid phase peptide synthesis using a polyacrylic support in aqueous solution

  • US 5,175,254 A
  • Filed: 09/26/1991
  • Issued: 12/29/1992
  • Est. Priority Date: 09/24/1988
  • Status: Expired due to Fees
First Claim
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1. A method for solid phase peptide synthesis, the method comprising attaching a first amino acid residue selected from the twenty naturally occurring L-alpha amino acids to a hydrophilic polyacrylic resin, coupling one or more further amino acid residues of the twenty naturally occurring L-alpha amino acids to form a peptide and detaching the peptide from the resin, characterized in that the coupling of the said amino acid residues to the polyacrylic resin includes steps of washing the resin in water, one or more aqueous solutions, or a combination of the foregoing.

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