Time-compressed chromatography in mass spectrometry

  • US 5,175,430 A
  • Filed: 05/17/1991
  • Issued: 12/29/1992
  • Est. Priority Date: 05/17/1991
  • Status: Expired due to Term
First Claim
Patent Images

1. A method for reducing the time required in chromatographic analyses comprising the following:

  • compression in time of a chromatographic separation of analytes on a chromatographic column resulting in a loss of chromatographic resolution;

    transport of the column eluent into a mass spectrometer ion source;

    generation of ions within the ion source;

    mass analysis by rapid array detection mass spectrometry;

    acquisition and computer processing of said mass spectral information including mathematical deconvolution of overlapping chromatographic peaks; and

    said deconvolution constituting recovery of all of the chromatographic analytical information.

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