Effervescent dosage form with microparticles

  • US 5,178,878 A
  • Filed: 04/16/1992
  • Issued: 01/12/1993
  • Est. Priority Date: 10/02/1989
  • Status: Expired due to Term
First Claim
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1. A solid pharmaceutical dosage form adapted for direct oral administration to a human comprising:

  • a mixture of at least one saliva activated effervescent agent and a plurality of microparticles, each said microparticle including at least one systemically distributable pharmaceutical ingredient and a protective material substantially encompassing said pharmaceutical ingredient, said microparticles having at least about 70 percent 30-minute release, said mixture being present as a tablet of a size and shape adapted for direct oral administration to a human patient, said tablet being substantially completely disintegrable so as to release said microparticles upon exposure to saliva, said at least one effervescent agent being present in an amount which is effective to aid in rapid disintegration of said tablet, without chewing, and thereby release said microparticles.

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