Blood constituent measurement

• US 5,179,951 A
• Filed: 12/20/1991
• Issued: 01/19/1993
• Est. Priority Date: 04/19/1990
• Status: Expired due to Fees

• Current Assignee: Integ Incorporated (Johnson & Johnson)
• Original Assignee: Inomet, Inc.
• Inventors: Knudson, Mark B.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): Pontius, Kevin
• Application Number:
  US07/812,565
• Time in Patent Office: 396 Days
• Field of Search: 128/633, 128/634, 128/664, 128/665, 356/39-41
• US Class Current: 600/310
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/1491 Heated applicators
• CPC Class Codes: A61B 5/6817 Ear canal

Abstract

An apparatus and method are disclosed for determining a level of a constituent such as glucose in a body fluid such as blood. The apparatus and method utilize a light generator for generating a testing light of known intensity with the testing light including a wavelength absorbable by the constituent being measured. The light generator also generates a reference light of known intensity having a wavelength not absorbable by the constituent being measured. The testing light and reference light are directed toward a fluid containing an unknown concentration of a constituent. A light detector is provided for measuring the intensity of the testing light and reference light being spectrally modified by the fluid. A light path distance measurer is provided for measuring a distance of a light path traveled by the testing light and reference light. A circuit is provided for calculating a level of the constituent in the fluid in response to a reduction in intensity of the testing light and reference light and in response to the measured distance.

Claims

1. An apparatus for determining a level of a constituent in a body fluid, said apparatus comprising:

a first light transmitting member;

a second light transmitting member;

separation means for separating said first and second members by a separation distance with said first light transmitting member disposed to direct light to said second light transmitting member;

light generating means for generating a testing light of known intensity with said testing light including a wavelength absorbable by said constituent and directing said testing light to said first light transmitting member, said light generating means further including means for generating the reference light of known intensity and having a wavelength nonabsorbable by said constituent;

light detecting means for measuring an intensity of said testing light and said reference light in said second transmitting member;

light path measurement means for measuring a distance between said first and second light transmitting members;

circuit means for calculating a level of said constituent in a fluid between said first and second transmitting members in response to a reduction in intensities of said testing light and said reference light and in response to said distance measured by said light path measurement means.

2. An apparatus according to claim 1 wherein said separation means includes means for defining an enclosed volume between said first and second light transmitting members with said separation means further including means for selectively passing into said volume a constituent from an exterior of said volume.

3. An apparatus according to claim 2 wherein said separation means includes a constituent permeable membrane.

4. An apparatus according to claim 2 wherein said first and second light transmitting members are optical fibers and said separation means is a permeable membrane tubing with said first and second light transmitting members fixed within opposite ends of said tubing.