Process for forming a fluoromethyl ketone

  • US 5,210,272 A
  • Filed: 08/14/1991
  • Issued: 05/11/1993
  • Est. Priority Date: 02/16/1990
  • Status: Expired due to Fees
First Claim
Patent Images

1. A method for forming a fluoromethyl ketone from a carboxylic acid which comprises the steps ofa. converting the carboxylic acid to give the corresponding imidazolide,b. reacting the imidazolide with a magnesium fluoromalonate of the formula ##STR26## wherein X is --O-- or --S--, andR'"'"' is an a hydrogenatively cleavable groupto yield the corresponding beta-keto-alpha-fluoroester of the carboxylic acid, andc. hydrogenating the beta-keto-alpha-fluoroester of the carboxylic acid thereby causing its decarboxylation and formation of the fluoromethyl ketone.

View all claims
    ×
    ×

    Thank you for your feedback

    ×
    ×