DNA encoding and methods of production of insulin-like growth factor binding protein BP53

  • US 5,258,287 A
  • Filed: 03/22/1988
  • Issued: 11/02/1993
  • Est. Priority Date: 03/22/1988
  • Status: Expired due to Term
First Claim
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1. An isolated DNA molecule comprising a sequence that hybridizes, under stringent conditions of 50% formamide with 0.75M NaCl and 0.075M sodium citrate, at 42°

  • C., to the portion of the DNA sequence of FIG. 3 coding for mature BP53 or the preprotein for BP53 and which encodes a BP53 protein that binds to IGF-I or IGF-II, excluding BP28, PP12, and HEP-G2.

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