Portable fluid administration container with integral heat exchanger

• US 5,263,929 A
• Filed: 08/28/1991
• Issued: 11/23/1993
• Est. Priority Date: 08/28/1991
• Status: Expired due to Fees

• Current Assignee: Normothermic Technologies Incorporated
• Original Assignee: Normothermic Technologies Incorporated
• Inventors: Davis, James F., Falcone, Robert E.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Bockelman, Mark
• Application Number:
  US07/751,396
• Time in Patent Office: 818 Days
• Field of Search: 128/399-403, 128/DIG. 24, 604/113, 604/114, 604/82-91, 604/408, 604/410, 604/416, 126/263
• US Class Current: 604/89
• CPC Class Codes: A61M 2205/364 by chemical reaction
• CPC Class Codes: A61M 5/445 the media being heated in the reservoir, e.g. warming bloodbags

Abstract

The present invention is addressed to providing an infusion administration container which is effective in establishing about a normothermic temperature of a physiologic solution for its infusion into an animal, such as a human medical patient. The infusion administration container comprises an upper flexible bladder adapted to contain at least one first chemical agent and a first lower flexible bladder adapted to contain at least one second chemical agent. These first and second chemical agent(s), when combined, result in an exothermic reaction. A passageway interconnects the upper bladder and first lower bladder with manually openable closure means disposed within the passageway to separate the chemical agents until the closure means is opened. A second lower flexible bladder, adapted to contain an administrable physiologic fluid, is disposed in heat-exchange relationship with the first lower bladder. The passageway is dimensioned such that when the closure means is opened, the first chemical agent(s) flows into the first lower flexible bladder at a rate sufficient so the resulting exothermic reaction generates sufficient heat to maintain the physiologic fluid within a normothermic temperature range for its infusion into the desired patient. The present invention also includes a method of maintaining a physiologic fluid within a normothermic temperature range for its infusion into a desired patient.

Claims

1. An infusion administration container for infusing a physiologic fluid into an animal, which comprises:

a first flexible bladder divided into at least two compartments separated from one another, each of said compartments containing at least one first chemical agent;

a second flexible bladder disposed outside said first flexible bladder and containing at least one second chemical agent, said first and second chemical agents when combined resulting in an exothermic reaction;

passageways interconnecting each of said compartments of said first bladder with said second bladder;

manually openable closure means disposed within each of said passageways;

a third flexible bladder adapted to contain an administrable physiologic fluid and being in a contacting heat-exchange relationship with said second bladder, said first and second chemicals provided in amounts sufficient and said passageways being dimensioned such that when said closure means is opened, said at least one first chemical agent flows into said second flexible bladder at a rate sufficient so that the resulting exothermic reaction with said at least one second chemical agent generates sufficient heat to maintain said physiologic fluid at about 32 degrees to 42 degrees Centigrade for its infusion into said animal; and

fluid conduction means adapted to conduct said physiologic fluid into said animal.

2. The infusion administration container of claim 1 wherein one of said at least one first or at least one second chemical agents comprises water and the other of said at least one second or at least one first chemical agents, respectively, comprises a hydratable compound.

3. The infusion administration container of claim 2 wherein said hydratable compound comprises magnesium sulfate.

4. The infusion administration container of claim 1 wherein one of said at least one first or at least one second chemical agents comprises an acid and the other of said at least on second or at least one first chemical agents, respectively, comprises a base.

5. The infusion administration container of claim 1 wherein said compartments of said first flexible bladder each contain said at least one first chemical agent wherein said at least one first chemical agent contained in each of said compartment differs from said at least one first chemical agent in the respective other of said compartments, with respect to a characteristic selected from the group consisting of:

(a) chemical nature, (b) physical form, (c) concentration, and (d) volume; and

wherein said first lower bladder contains said at least one second chemical agent.

6. The infusion, administration container of claim 1 wherein said second flexible bladder is disposed within said third flexible bladder.

7. The infusion administration container of claim 1 wherein said second flexible bladder is subdivided into a plurality of chambers.

8. The infusion administration container of claim 7 wherein said plurality of chambers comprises between 2 and 8 of said chambers.

9. The infusion administration container of claim 1 wherein said infusion administration container is made from a material selected from the group consisting of polyvinylchlorides.

19. An infusion administration container according to claim 1 wherein said container additionally comprises attachment means whereby said container may be suspended by said attachment means such that said first flexible bladder is held in a position above said second flexible bladder.

10. A method for maintaining a physiologic fluid at about a normothermic temperature for its infusion into an animal which comprises the steps of:

(a) providing an infusion administration container which comprises a first flexible bladder divided into at least two compartments separated from one another, each of said compartments containing at least one first chemical agent, a second flexible bladder disposed outside said first flexible bladder and containing at least one second chemical agent wherein said first and second chemical agents when combined result in an exothermic reaction;

there being passageways interconnecting each of said compartments of said first flexible bladder and said second bladder, with manually openable closure means disposed within each of said passageways to separate said at least one first chemical agent in each of said compartments of said first flexible bladder from said at least one second chemical agent until each said closure means is opened, said closure means thereby comprising a series of said closure means, and a third flexible bladder containing an administrable physiologic fluid, and said third flexible bladder being in a contacting heat exchange relationship with said second flexible bladder and said third flexible bladder containing fluid conduction means adapted to conduct said physiologic fluid into said animal; and

(b) opening each said closure means of said series in sequence, so that the resulting exothermic reaction generates sufficient heat to maintain the physiologic fluid at about 32 degrees to 42 degrees Centigrade for its infusion into said animal; and

`allowing said physiologic fluid to flow through said fluid conduction means into said animal.

11. The method of claim 10 additionally comprising the step of agitating said container upon said opening of said closure means and during said infusion into said animal.

12. The method of claim 10 wherein one of said at least one first or at least one second chemical agents comprises water and the other of said at least one second or at least one first chemical agents, respectively, comprises a hydratable compound.

13. The method of claim 12 wherein said hydratable compound comprises magnesium sulfate.

14. The method of claim 10 wherein one of said at least one first or at least one second chemical agents comprises an acid and the other of said at least one second or at least one first chemical agents, respectively, comprises a base.

15. The method of claim 10 wherein said first lower flexible bladder is disposed within said second lower flexible bladder.

16. The method of claim 10 wherein said second flexible bladder is subdivided into a plurality of chambers.

17. The method of claim 16 wherein said plurality of chambers comprises between 2 and 8 of said chambers.

18. The method of claim 10 which is made from a material selected from the group consisting of polyvinylchlorides.