Transdermal or interdermal drug delivery devices

• US 5,279,544 A
• Filed: 11/25/1992
• Issued: 01/18/1994
• Est. Priority Date: 12/13/1990
• Status: Expired due to Term

• Current Assignee: Elan Pharma International Limited (Perrigo Company PLC)
• Original Assignee: Sil Medics Ltd.
• Inventors: Zucker, Shlomo, Gross, Joseph
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US07/981,652
• Time in Patent Office: 419 Days
• Field of Search: 604/20, 604/145, 604/290, 128/798, 128/802, 128/803
• US Class Current: 604/20
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61N 1/303 Constructional details electrodes for external use A61N1/0428

Abstract

A transdermal drug delivery device includes a liquid reservoir for a liquid drug to be delivered, and a drug delivery body which includes a plurality of tubular elements extending through the body, each having an inlet end communicating with the liquid reservoir, and an outlet end engageable with the subject'"'"'s skin to conduct the liquid drug directly to the subject'"'"'s skin.

Claims

1. A drug delivery device for delivering a liquid drug to a subject via the subject'"'"'s skin, comprising:

a housing;

a liquid reservoir in said housing for a liquid drug to be delivered;

and a drug delivery body of resilient deformable material carried by said housing and having one side communicating with one side of the liquid reservoir, and the opposite side exposed to engage the skin of the subject to receive the drug;

characterized in that said drug delivery body includes a plurality of stiff tubular elements extending through the body, each having an inlet end communicating with said liquid reservoir, and an outlet end at said opposite side of the drug delivery body to conduct the liquid drug directly to said opposite side.

2. The device according to claim 1, further including control means for controlling the pressure in said reservoir for controlling the rate of delivery of the drug therefrom via said plurality of stiff tubular elements extending through the drug delivery body.

3. The device according to claim 2, wherein said control means includes a first displaceable membrane for controlling the pressure in said reservoir in order to control the rate of delivery of the drug from the reservoir via said tubular elements to the subject'"'"'s skin.

4. The device according to claim 3, wherein said drug delivery body is in the form of a second displaceable membrane through which said plurality of stiff tubular elements extend and which is displaceable by the pressure in said reservoir.

5. The device according to claim 4, wherein said control means further includes an electrolytic cell having electrodes and capable of generating a gas to displace said first membrane corresponding to electrical current applied to the electrodes of said electrolytic cell.

6. The device according to claim 5, wherein said housing further includes a compartment for a battery for supplying current to said electrolytic cell.

7. The device according to claim 6, wherein said housing further includes a removable cover carrying electrical contacts engageable with a battery when in said battery compartment and with one of said electrodes in the electrolytic cell when the cover is attached to the housing.

8. The device according to claim 7, wherein said cover is formed with an opening occupied by a third membrane such that one face of the third membrane is exposed to the gas generated by the electrolytic cell and the opposite face is exposed to the atmosphere.

9. The device according to claim 2, wherein said control means includes a partition between the liquid reservoir and the drug delivery body and formed with a metering orifice for metering the flow of the drug from the reservoir to said drug delivery body.

10. The device according to claim 1, wherein said plurality of stiff tubular elements have inner diameters of less than 1 mm.

11. The device according to claim 1, wherein said plurality of stiff tubular elements project at least 0.1 mm from said opposite side of the drug delivery body.

12. The device according to claim 1, wherein tips of said stiff tubular elements are cut at a bias to pierce the outer layer of dead cells on the skin and thereby to enhance the penetration of the drug.

13. The device according to claim 1, wherein said drug delivery body includes at least 50 of said stiff tubular elements.

15. The device according to claim 10, wherein said first electrode extends around the outer periphery of the drug delivery body carrying said plurality of tubular elements.

14. A drug delivery device for delivering a liquid drug to a subject via the subject'"'"'s skin, comprising:

a housing;

a liquid reservoir in said housing for a liquid drug to be delivered;

a drug delivery body carried by said housing and having one side communicating with one side of the liquid reservoir, and an opposite side exposed to engage the skin of the subject to receive the drug;

a plurality of stiff tubular elements extending through the body, each having an inlet end communicating with said liquid reservoir, and an outlet and at said opposite side of the drug delivery body to conduct the liquid drug directly to said opposite side;

a first electrode exposed for contact with the skin of a subject;

a second electrode in contact with the liquid drug in said reservoir;

and means for applying a voltage between said first and second electrodes.

16. A transdermal drug delivery device for delivering a liquid drug to a subject via the subject'"'"'s skin, comprising:

a housing attachable to the subject'"'"'s body;

a liquid reservoir in said housing for a liquid drug to be delivered;

a drug delivery body carried by said housing and having one side communicating with one side of the liquid reservoir and the opposite side exposed to engage the skin of the subject to receive the drug;

a plurality of stiff tubular elements extending through said body, each having an inlet end communicating with said liquid reservoir and an outlet end engageable with the subject'"'"'s skin;

and control means including a displaceable membrane for controlling the rate of delivery of the drug from said reservoir via said tubular elements to the subject'"'"'s skin at a rate controlled by the displacement of said membrane.

17. The device according to claim 16 wherein said drug delivery body includes at least 50 of aid stiff tubular elements each having inner diameters of less than 1 mm.

18. The device according to claim 17, wherein said drug delivery body is of resilient, deformable material.

19. The device according to claim 16, wherein said housing further includes a first electrode exposed for contact with the skin of a subject, a second electrode in contact with the liquid drug in said reservoir, and means for applying a voltage between said first and second electrodes.

20. The device according to claim 19, wherein said first electrode extends around the outer periphery of the drug delivery body carrying said plurality of tubular elements.

21. The device according to claim 19, wherein said first and second electrodes are of a silicone polymer containing an electrically-conductive filler.