Comparative analysis of body surface potential distribution during cardiac pacing

• US 5,311,873 A
• Filed: 08/28/1992
• Issued: 05/17/1994
• Est. Priority Date: 08/28/1992
• Status: Expired due to Fees

• Current Assignee: Corporation De L'Ecole Polytechnique De Montreal
• Original Assignee: Ecole polytechnique
• Inventors: Savard, Pierre, Nadeau, Reginald, Dubuc, Marc
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Getzow, Scott M.
• Application Number:
  US07/937,487
• Time in Patent Office: 627 Days
• Field of Search: 128/696, 128/419 P, 128/697, 128/786, 128/419 PT, 128/898
• US Class Current: 600/508
• CPC Class Codes: A61B 2034/2053 Tracking an applied voltage gradient
• CPC Class Codes: A61N 1/372 Arrangements in connection with the implantation of stimulators

Abstract

Body surface potential map (BSPM) pace-mapping is a system and method that can be used in medicine to localize with precision the site of origin of abnormal cardiac electrical activity and to guide the positioning of a catheter over this site of origin, such as the site of ventricular preexcitation in patients with the Wolff-Parkinson-White syndrome or the focus of ectopic activity in patients with tachycardia. Body surface potential distributions are measured with a large number of electrodes, e.g. 24 to 128, distributed over the entire torso surface. The electrical signals are first amplified, converted into digital data and treated to remove electrical or muscle artifacts. Data recorded during abnormal activation (reference beat) are aligned with data recorded during cardiac pacing (paced beat) so as to maximize the average value of the correlation coefficient between the reference and the paced potential distributions during a preset time interval following the beginning of the QRS complex. Reference and paced maps showing color-coded isopotential contour lines are displayed side by side for the same time instant. Visual analysis of these maps according to previously published criteria determines the relative position of the pacing catheter with respect to the focus of abnormal activation, and gives information so as to guide the catheter toward the focus.

Claims

1. A method of locating a position of interest in the heart of a patient and in positioning a surgical instrument at this position, comprising the steps of:

A. placing a plurality of electrodes on the surface of said patient in the area of the torso of the patient;

B. obtaining readouts from said electrodes during a pre-excitation phase or at the onset of an abnormal beat and forming therefrom a first body surface potential map (BSPM);

C. estimating said position of interest from said first BSPM;

D. placing said surgical instrument at said estimated position;

E. pacing the heart of said patient with an electrical signal applied through said surgical instrument;

F. obtaining readouts from said electrodes during said paced phase and forming a further BSPM therefrom;

G. determining from said further BSPM, when compared with the first BSPM, if the surgical instrument is in the correct position;

H. if the instrument is not in the correct position, moving the instrument in a direction as indicated by the comparison of the further BSPM with the first BSPM;

I. repeating steps E. to G. until the surgical instrument is at the position of interest.

2. A method as defined in claim 1 wherein said first BSPM is obtained during the delta wave for a sinus rhythm beat in WPW patients or at the beginning of the QRS in patients with ventricular tachycardia.

3. A method as defined in claim 1 wherein said instrument is a catheter and said catheter is inserted into the ventricles of said patient'"'"'s heart.

4. A method as defined in claim 1 wherein said BSPM'"'"'s are displayed on a CRT terminal.

5. A method as defined in claim 4 and including the further step of selecting one of said electrodes to provide a reference signal to permit the manual selection of a window containing the beat to be analyzed.

6. A method as defined in claim 1 and including a preliminary step, carried out before step A, of automatically identifying and correcting faulty leads, that is, leads which carry signals which are saturated as well as signals contaminated by excessive electrical noise.

7. A method as defined in claim 6 wherein said preliminary step includes interpolating signals from valid leads near leads which have been identified as faulty.

8. A method as defined in claim 1 wherein, in steps A and F, the onset of a QRS complex is automatically detected and the value of the potential at the QRS onset is subtracted from the read-outs of all leads so as to correct for any baseline shifts.

9. A method as defined in claim 1 wherein the determination as recited in step G is obtained by as formed in step B and the BSPM as formed in step F.

10. A method as defined in claim 9 wherein the data of the read-outs obtained in step B are aligned with the data of the read-outs obtained in step F so as to maximize the average value of said correlation coefficient.

11. A method as defined in claim 10 wherein said data is aligned by analyzing the correlation coefficient during a preset time interval following the beginning of the QRS complex.

12. A method as defined in claim 11 wherein said BSPMs are displayed on a CRT;

and including the further step of displaying the BSPM formed in step B during said preset time interval alongside of the BSPM formed in step F during said preset time interval on said CRT for visual comparison.

13. A method as defined in claim 12 wherein said BSPMs comprise isopotential lines including a zero isopotential line, a maximum potential marker and a minimum potential marker;

and including the further step of displaying only the zero isopotential line and the locations of the maximum and minimum potential values for said BSPMs.

14. A method as defined in claim 13 and including the step of providing a plot of correlation coefficients for predetremined instances during said preset time interval.

15. A method as defined in claim 6 and including the step of selecting a dynamic range of value for the read-outs obtained from said electrodes;

determining the number of time instances at which each read-out exceeds a preset percentage of this dynamic range;

determining if this number of instances corresponds to a consecutive duration greater than a preset duration; and

if said read-out from an electrode exceeds the preset duration, considering that the output of this read-out of this electrode is faulty.

16. A method as defined in claim 15 wherein the preset percentage is 95% and the preset duration is 50 msec.

17. A method as defined in claim 6 and including filtering the read-out of each electrode with a numerical high-pass filter with a cut-off frequency of 50 Hertz and determining if the total power of the filtered signal exceeds a preset threshold;

and

if the filtered signal exceeds the preset threshold, considering the read-out of said electrode to be faulty.

18. A method as defined in claim 7 wherein the interpolation is performed by using read-outs of neighboring leads within a preset radius around the faulty lead.

19. A method as defined in claim 17 wherein said preset radius is twice the distance between electrodes.

20. A method as defined in claim 1 wherein said plurality of electrodes comprises between 24 and 128 electrodes;

said electrodes being distributed over the front, sides and back of the torso.

21. A method as defined in claim 20 wherein said read-outs from said electrodes are amplified, filtered, digitized and stored on a magnetic disc.