Process for defibrillation pretreatment of a heart

• US 5,314,448 A
• Filed: 10/28/1991
• Issued: 05/24/1994
• Est. Priority Date: 10/28/1991
• Status: Expired due to Term

• Current Assignee: Ela Medical S.A. (LivaNova Plc)
• Original Assignee: Angeion Corporation (Niterra Co., Ltd.)
• Inventors: Kroll, Mark W., Adams, Theodore P.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Getzow, Scott M.
• Application Number:
  US07/783,763
• Time in Patent Office: 939 Days
• Field of Search: 128/419 D
• US Class Current: 607/5
• CPC Class Codes: A61N 1/3906 characterised by the form of the shockwave
• CPC Class Codes: A61N 1/3956 Implantable devices for applying electric shocks to the heart, e.g. for cardioversion

Abstract

The present invention is a process to apply an electrical pretreatment to a fibrillating heart that begins the process of organizing the action of the chaotically contracting myocardial cells, so that the defibrillating waveform applied after the pretreatment can accomplish its task with less energy than would otherwise be required. The same electrodes are employed for both pretreatment and defibrillation. In one preferred embodiment a long-duration, low-voltage pretreatment pulse is generated directly by battery and voltage-conversion circuitry, and is followed by the defibrillation pulse delivered from the previously charged capacitor. In variations on this embodiment, the capacitor is charged during the pretreatment pulse, or between the pretreatment and defibrillation pulses. In other preferred embodiments, pretreatment consists of a train of pulses of appreciably lower energy than the defibrillation pulse, and with inter-pulse time adjusted so that necessary capacitor recharging can be accomplished, so that the same capacitor (a component of dominant size) can be used for all pretreatment pulses and for the defibrillation pulse as well. Wide-ranging variations of pulse duration, height spacing and waveform are included, as well as selected polarity inversions.

Claims

1. A process for the electrical pretreatment of a fibrillating heart comprising:

a. at least one low-energy pretreatment pulse applied to the heart before application of a defibrillation pulse to the heart;

b. at least one of said pretreatment pulses having a duration that is long compared to that of said defibrillation pulse and a voltage that is low compared to that of said defibrillation pulse; and

c. said pretreatment pulses being spaced away from said defibrillation pulse by a time interval.

2. A process for the electrical pretreatment of a fibrillating heart comprising:

a. at least one low-energy pretreatment pulse applied to the heart before application of a defibrillation pulse to the heart; and

,

b. wherein said pretreatment pulse is spaced away from said defibrillation pulse by a time interval of at least 100 milliseconds and said defibrillation pulse is a biphasic pulse.

3. A process for the electrical pretreatment of a fibrillating heart comprising:

a. low-energy pretreatment pulses applied to the heart before application of a defibrillation pulse to the heart; and

,

b. wherein the electrical pretreatment comprises a train of said low-energy pulses with zero-voltage intervals.

4. The process of claim 3 wherein the substantially zero-voltage interval between the pulses in the train is between 100 milliseconds and 400 milliseconds.

5. The process of claim 3 wherein all substantially zero-voltage intervals between the pulses in the train are equal.

6. The process of claim 3 wherein the substantially zero-voltage intervals between the pulses in the train are variable.

7. The process of claim 3 wherein the substantially zero-voltage intervals between the pulses in the train increase monotonically in duration as the train progresses.

8. The process of claim 3 wherein the substantially zero-voltage intervals between the pulses in the train decrease monotonically in duration as the train progresses.

9. The process of claim 3 wherein the substantially zero-voltage intervals between the pulses in the train vary nonmonotonically in duration as the train progresses.

10. The process of claim 3 wherein a capacitor is utilized for generating the pretreatment and defibrillation waveforms.

11. The process of claim 3 wherein each pulse of the train has a duration that is short compared to that of a conventional monophasic defibrillation pulse and a voltage that is comparable to that of a conventional monophasic defibrillation pulse.

12. The process of claim 3 wherein each pulse of the train has a duration that is one-tenth to one-half that of a conventional monophasic defibrillation pulse and a voltage that is one-tenth to one-half that of a conventional monophasic defibrillation pulse.

13. The process of claim 3 wherein the pretreatment increases the temporal organization of the myocardial cells.

14. The process of claim 3 comprising a monophasic defibrillation pulse.

15. The process of claim 3 comprising a biphasic defibrillation pulse.

16. The process of claim 3 wherein a capacitor is utilized for generating the pretreatment and defibrillation waveforms.

17. The process of claim 3 comprising pulses grouped in clusters of at least two.

18. The process of claim 3 comprising short pulses intermixed with longer pulses.

19. The process of claim 3 comprising a pulse train combined with one or more long-duration, low-voltage pulses.

20. The process of claim 3 wherein at least one of these pulse-train attributes is varied within the duration of the train:

pulse length, pulse height, pulse spacing, or pulse waveforms.

21. The process of claim 20 wherein the variation is stepwise.

22. The process of claim 20 wherein the variation is smooth.

23. The process of claim 20 wherein the variation is monotonic.

24. The process of claim 20 wherein the variation is nonmonotonic.

25. The process of claim 20 with the added variation of pulse polarity.

26. A process for the electrical pretreatment of a fibrillating heart comprising:

a. at least one low-energy pretreatment pulse applied to the heart before application of a defibrillation pulse to the heart, wherein said pretreatment pulse is spaced away from the defibrillation pulse by a time interval of sufficient length to permit recharging of a defibrillation capacitor; and

b. at least one pulse having a duration that is long compared to that of said defibrillation pulse and a voltage that is low compared to that of said defibrillation pulse.

27. A process for the electrical pretreatment of a fibrillating heart comprising:

a. at least one low-energy pretreatment pulse applied to the heart before application of a defibrillation pulse to the heart, wherein said pretreatment pulse is spaced away from the defibrillation pulse by a time interval; and

b. at least one pulse having a duration that is long compared to that of said defibrillation pulse and a voltage that is low compared to that of said defibrillation pulse.