Reservoir module for a drug delivery system

• US 5,324,258 A
• Filed: 01/22/1993
• Issued: 06/28/1994
• Est. Priority Date: 01/30/1992
• Status: Expired due to Fees

• Current Assignee: Hospira Australia Pty Limited (Pfizer Inc.)
• Original Assignee: F H Faulding & Co Limited (Mayne Pharma)
• Inventors: Rohrbough, John
• Primary Examiner(s): Yasko, John D.
• Assistant Examiner(s): GRING, NOELLE K
• Application Number:
  US08/007,619
• Time in Patent Office: 522 Days
• Field of Search: 604/86, 604/122, 604/123, 604/129, 604/131-133, 604/140, 604/141, 604/143, 604/146, 604/147, 604/148, 604/149, 604/150, 604/151, 604/152, 604/154, 604/207, 604/208 , 604/232-234, 604/236, 604/244, 604/249, 604/403, 604/404, 604/411, 604/415, 604/201, 604/203, 604/205, 604/206, 604/213, 604/214, 604/218, 222/251, 222/257, 222/282, 222/566
• US Class Current: 604/86
• CPC Class Codes: A61M 2039/1077 Adapters, e.g. couplings adapting a connector to one or several other connectors
• CPC Class Codes: A61M 39/14 for connecting tubes having sealed ends needle sets A61M5/162; having valves closing automatically on disconnection of line A61M39/26
• CPC Class Codes: A61M 5/162 Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube in jet-action syringes A61M5/30; connectors for tubes having sealed ends and a needle for piercing them A61M39/14

Abstract

A medicament reservoir module for attachment to a pumping and control module includes a conventional medicament vial closed at one end by a penetrable stopper, which is inserted to operate as a piston in the vial. A hollow needle, attached to an adaptor that releasibly connects to the stopper, pierces the stopper and provides a medicament flow path via a slack length of flexible tubing from the vial to a peristaltic pump in the pumping and control module. A housing supports the vial, encloses the adaptor, hollow needle, and slack tubing, and releasibly connects to the pumping and control module. Thereby, a detachable reservoir module is provided, permitting quick and reliable resupply of medicament directly from filled standard vials.

Claims

1. A medicament reservoir module for attachment to a pumping unit containing pumping means and control mechanism for a drug delivery system, said reservoir module, comprising:

a housing adapted for releasable connection to said pumping unit and for supporting a vial of liquid medicament intended for use in said drug delivery system, said vial having length and being closed at one end by a base and having an open second end and a penetratable vial stopper movable as a piston in said vial;

an adaptor, including;

a collar having first means for attachment to said vial stopper and having second means for attachment to a medicament delivery tube;

a hollow needle mounted to said collar for penetrating said stopper when a vial is connected to said adaptor by said first means for attachment;

a flexible medicament delivery tube means having a first end connected to said second attachment means for movement with said adaptor, and a second end portion releasably fixed in relation to said housing for operative pumping engagement with said pumping means when said pumping unit is connected to said housing, said tube means being resilient and having clack between said second end portion thereof and said adaptor, permitting said adaptor to move a distance at least equal to the length of said vial.

2. A medicament reservoir module for a drug delivery system as in claim 1, wherein said first means for attachment includes a recess formed in said adapter, said needle extending from a base of said recess, a surface portion of said recess releasibly connecting with a surface portion of said penetrable stopper.

3. A medicament reservoir module for a drug delivery system as in claim 2, wherein said stopper and said recess are cylindrical and said surface portions of said stopper and said recess, are threaded with mating threads.

4. A medicament reservoir module for a drug delivery system as in claim 1, wherein a portion of said delivery tube is resiliently coiled to provide at least a portion of said slack.

5. A medicament reservoir module for a drug delivery system as in claim 1, wherein said second means for attachment on said adaptor is a cylindrical nozzle communicating with said needle and said delivery tube.

6. A medicament reservoir module for a drug delivery system as in claim 1, wherein said second end portion of said tubing is releasably fixed outside said housing, whereby said second end portion can be acted on by said pumping means when said housings and said pumping unit are connected together.

7. A medicament reservoir module for a drug delivery system as in claim 1, wherein said second end portion of said tube means is located adjacent the pumping means so that it is acted on lengthwise by said pumping means, which includes a peristaltic pump producing linear pumping action when said housing is connected to the pumping unit.

8. A medicament reservoir module for a drug delivery system as in claim 1, further comprising one of said medicament vials with said penetrable stopper in said second housing, said one vial being attached to said adaptor with said needle penetrating said stopper, whereby a continuous medicament flow path is provided between said vial and said delivery tube.

9. A medicament reservoir module for a drug delivery system as in claim 8, further comprising a second medicament vial in said second housing connected to a second adaptor and being connected in parallel with said one medicament vial to supply medicament flow to be acted on by said pumping means, said tube means including a tube connected to said second adaptor for forming said parallel flow path.

10. A medicament reservoir module for a drug delivery system as in claim 6, wherein said second tubing portion is acted on lengthwise by said pumping means, which includes a peristaltic pump producing linear pumping action.

11. A medicament reservoir module for attachment to a pumping unit containing pumping means and control mechanism for a drug delivery system, said reservoir module, comprising:

a first housing for supporting a vial of liquid medicament intended for use in said drug delivery system, said vial having length and being closed at one end of a base and having an open second end and a penetratable stopper mounted as a piston in said vial;

an adaptor including;

a collar having first means for attachment to said vial stopper, and having second means for attachment to a medicament delivery tube;

a hollow needle mounted to said collar for penetrating said stopper when a vial is connected to said adaptor by said first means for attachment;

a second housing adapted for releasable connection at a first interface with said pumping unit and at a second interface with said first housing;

a flexible medicament delivery tube means in said second housing, said tube means having a first end connected to said second attachment means for movement with said adaptor, and a second portion releasably fixed in relation to said second housing for operative pumping engagement with said pumping means at said first interface when said pumping unit is connected to said second housing, said tube means being resilient and having slack between said second end portion thereof and said adaptor, permitting said adaptor to move a distance at least equal to the length of said vial.

12. A medicament reservoir module for a drug delivery system as in claim 11, wherein said first means for attachment includes a recess formed in said one adaptor end, said needle extending from a base of said recess, a surface portion of said recess releasibly connecting with a surface portion of said penetratable stopper.

13. A medicament reservoir module for a drug delivery system as in claim 12, wherein said stopper and said recess are cylindrical and said surface portions of said stopper and said recess are threaded with mating threads.

14. A medicament reservoir module for a drug delivery system as in claim 11, wherein a portion of said delivery tube means is resiliently coiled in said second housing to provide at least a portion of said slack.

15. A medicament reservoir module for a drug delivery system as in claim 11, wherein said second means for attachment on said adaptor is a cylindrical nozzle communicating with said needle and said delivery tube.

16. A medicament reservoir module for a drug delivery system as in claim 11, wherein said second portion of said tube means is releasably fixed outside said second housing at said first interface, whereby said second portion can be acted on by said pumping means when said pumping unit and second housing are connected together.

17. A medicament reservoir module for a drug delivery system as in claim 11, wherein said second portion of said tube means is located adjacent the pumping means so that it is acted on lengthwise by said pumping means, which includes a peristaltic pump producing linear pumping action when said second housing is connected to the pumping unit.

18. A medicament reservoir module for a drug delivery system as in claim 11, further comprising one of said medicament vials with said penetrable stopper in said first housing, said one vial being attached to said adaptor with said needle penetrating said stopper, whereby a continuous medicament flow path is provided between said vial and said delivery tube means.

19. A medicament reservoir module for a drug delivery system as in claim 18, further comprising a second medicament vial in said first housing connected to a second adaptor and being connected in parallel with said one medicament vial to supply medicament flow to be acted on by said pumping means, said tube means including a tube connected to said second adaptor for forming said parallel flow path.

20. A medicament reservoir module for a drug delivery system as in claim 16, wherein said second portion of said tube means is acted on lengthwise by said pumping means, which includes a peristaltic pump producing linear pumping action.