Low dose temazepam

• US 5,326,758 A
• Filed: 03/17/1993
• Issued: 07/05/1994
• Est. Priority Date: 09/23/1986
• Status: Expired due to Term

• Current Assignee: Mallinckrodt Incorporated (Mallinckrodt plc)
• Original Assignee: Sandoz Pharmaceuticals Corp. (Novartis Ag)
• Inventors: Sterling, William R.
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US08/032,216
• Time in Patent Office: 475 Days
• Field of Search: 514/221
• US Class Current: 514/221
• CPC Class Codes: A61K 31/55 having seven-membered rings, e.g. azelastine, pentylenetetrazole
• CPC Class Codes: A61K 9/48 Preparations in capsules, e.g. of gelatin, of chocolate A61K9/0004 takes precedence; bite capsules A61K9/0056
• CPC Class Codes: C07D 243/24 Oxygen atoms

Abstract

This invention relates to a hard gelatin capsule containing no more than 5 to 10 milligrams of crystalline temazepam and its use in the treatment of transient insomnia.

Claims

1. A method of treating transient insomnia in a human in need of said treatment which comprises administering orally to said human a temazepam formulation consisting essentially of 5 to 10 milligrams of crystalline temazepam having a surface area of from 0.65 to 1.1 m² /g and 95% of the temazepam having a particle size of less than 65 microns.

2. A method of treating transient insomnia in a human in need of said treatment which comprises administering orally to said human a temazepam formulation consisting essentially of 6 to 8 milligrams of crystalline temazepam having a surface area of from 0.65 to 1.1 m² /g and 95% of the temazepam having a particle size of less than 65 microns.

3. A method of treating transient insomnia in a human in need of said treatment which comprises administering orally to said human a temazepam formulation consisting essentially of 7.5 milligrams of crystalline temazepam having a surface area of from 0.65 to 1.1 m² /g and 95% of the temazepam having a particle size of less than 65 microns.