Method for the metered application of a biochemical analytical liquid to a target
First Claim
1. A method for the metered application of a biochemical analytical liquid containing a heat-sensitive protein to a target, comprising the step of successively ejecting a plurality of quantities of the biochemical analytical liquid with high frequency from a jet chamber through a jet associated therewith onto the target by rapidly heating said biochemical analytical liquid by a heating element which is in thermal contact with said chamber for evaporating and expanding a part of the volume of the biochemical analytical liquid in the jet chamber so as to eject a predetermined quantity of the biochemical analytical liquid through the jet, wherein a majority of the heat-sensitive protein is not destroyed or denatured.
1 Assignment
0 Petitions
Accused Products
Abstract
A method for the metered application of a biochemical analytical liquid to a target, wherein the liquid is ejected in small quantities on to the target through a jet from a jet chamber by a procedure in which a partial volume of the liquid in the jet chamber is evaporated and expanded for a short time whenever a quantity of the liquid is to be ejected. The invention further relates to a device with a disposable jet element which contains prepackaged analytical liquid.
192 Citations
16 Claims
- 1. A method for the metered application of a biochemical analytical liquid containing a heat-sensitive protein to a target, comprising the step of successively ejecting a plurality of quantities of the biochemical analytical liquid with high frequency from a jet chamber through a jet associated therewith onto the target by rapidly heating said biochemical analytical liquid by a heating element which is in thermal contact with said chamber for evaporating and expanding a part of the volume of the biochemical analytical liquid in the jet chamber so as to eject a predetermined quantity of the biochemical analytical liquid through the jet, wherein a majority of the heat-sensitive protein is not destroyed or denatured.
-
15. A method of analyzing a biological sample by measuring a physically measurable change caused by the reaction between a biological sample and a reagent containing a heat-sensitive protein which comprises the steps of:
-
ejecting a drop of the reagent through a jet of a jet chamber onto an analysis element by rapidly heating, evaporating and expanding a part of the volume of the reagent contained in the jet chamber, wherein said volume part is expanded in volume by an amount substantially corresponding to the volume of the drop and wherein a majority of the heat-sensitive protein in the reagent is not destroyed or denatured, bringing the sample into contact with the reagent on the analysis element to cause said reaction, and measuring said change.
-
-
16. A method of analyzing a biological sample by measuring a physically measurable change caused by the reaction between a biological sample and a liquid reagent containing a heat-sensitive protein comprising the steps of:
-
successively ejecting a plurality of quantities of said liquid reagent from a jet chamber through a jet associated therewith onto an analysis element reagent domain by heating, evaporating and expanding a part of the volume of the liquid reagent contained in the jet chamber, the plurality of quantities of the liquid reagent being successively ejected in droplet form to form dots on the reagent domain, the jet and the analysis element being moved relative to one another in a manner such that the dots produced by the liquid reagent droplets on the reagent domain form a predetermined pattern on the reagent domain and a majority of the heat-sensitive protein in the reagent not being destroyed or denatured; conveying the analysis element to a sample delivery station; bringing a sample into contact with the dots on the reagent domain; and measuring any physically measurable change which occurs as a result of a reaction between the sample and the reagent.
-
Specification