Method for determining blood pressure utilizing a neural network
First Claim
1. A method for on-line calculation of a variable physiological parameter of a patient, said method comprising the steps of:
- (1.1) identifying the physiological parameter to be quantitatively monitored and estimated;
(1.2) coupling at least one sensor to the patient, said sensor being responsive to register changes in the physiological parameter, which changes are quantitatively dependent on a particular value for the parameter;
(1.3) activating the sensor to generate a sequence of on-line signals which register changes in the physiological parameter;
(1.4) transmitting the on-line signals as input signals to a computer system, including input nodes of a neural network supported by the computer system, which neural network is capable of calculating an output signal corresponding to a parameter value from the on-line, input signals;
(1.5) processing the input signals within the neural network to convert the sequence of input signals to an on-line output signal corresponding to a parameter value by applying fixed weighting factors to the input signals;
(1.6) generating said fixed weighting factors by retrieving weighting factors which were previously generated by applying a training algorithm with respect to previously collected training data comprising neural network input signals and corresponding known parameter values.
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Abstract
A method and device for indirect, quantitative estimation of blood pressure attributes and similar variable physiological parameters utilizing indirect techniques. The method of practice includes (i) generating a sequence of signals which are quantitative dependent upon the variable parameter, (ii) transmitting and processing the signals within a computer system and associated neural network capable of generating a single output signal for the combined input signals, (iii) directly determining an actual value for the parameter concurrent with the indirect generation of signals of the previous steps, (iv) applying weighting factors within the neural network at interconnecting nodes to force the output signal of the neural network to match the true value of the parameter as determined invasively, (v) recording the input signals, weighting factors and true value as training data within memory of the computer, and (vi) repeating the previous steps to develop sufficient training data to enable the neural network to accurately estimate parameter value upon future receipt of on-line input signals. Procedures are also described for preclassification of signals and artifact rejection. Following training of the neural network, further direct measurement is unnecessary and the system is ready for diagnostic application and noninvasive estimation of parameter values.
213 Citations
14 Claims
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1. A method for on-line calculation of a variable physiological parameter of a patient, said method comprising the steps of:
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(1.1) identifying the physiological parameter to be quantitatively monitored and estimated; (1.2) coupling at least one sensor to the patient, said sensor being responsive to register changes in the physiological parameter, which changes are quantitatively dependent on a particular value for the parameter; (1.3) activating the sensor to generate a sequence of on-line signals which register changes in the physiological parameter; (1.4) transmitting the on-line signals as input signals to a computer system, including input nodes of a neural network supported by the computer system, which neural network is capable of calculating an output signal corresponding to a parameter value from the on-line, input signals; (1.5) processing the input signals within the neural network to convert the sequence of input signals to an on-line output signal corresponding to a parameter value by applying fixed weighting factors to the input signals; (1.6) generating said fixed weighting factors by retrieving weighting factors which were previously generated by applying a training algorithm with respect to previously collected training data comprising neural network input signals and corresponding known parameter values. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method for on-line calculation of a variable physiological parameter of a patient, said method comprising the steps of:
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(12.1) identifying the physiological parameter to be quantitatively monitored and estimated; (12.2) coupling at least one sensor to the patient, said sensor being responsive to register changes in the physiological parameter, which changes are quantitatively dependent on a particular value for the parameter; (12.3) activating the sensor to generate a sequence of on-line signals which register changes in the physiological parameter; (12.4) transmitting the on-line signals as input signals to a computer system, including input nodes of a neural network supported by the computer system, which neural network is capable of calculating an output signal corresponding to a parameter value from the on-line, input signals; (12.5) processing the input signals within the neural network to convert the sequence of input signals to an on line output signal corresponding to a parameter value in accordance with the following substeps; 12.5a) processing the input signals within the neural network through at least one neural network layer having at least one node by applying fixed weighting factors to the input signals; - View Dependent Claims (14)
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13. 5b) generating said fixed weighting factors by retrieving fixed weighting factors which were previously determined by applying a training algorithm with respect to previously collected training data comprising neural network input signals and corresponding known parameter values to generate said fixed weighting factors;
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12.5c) for each input signal of each node within the neural network layer, calculating a product of the input signal and fixed weighting factor corresponding to each input signal and node combination; 12.5d) for each node within the neural network layer, summing the products of each input signal and fixed weighting factor combination calculated in the previous step 12.5c); 12.5e) for each node within the neural network layer, calculating a node output by applying an input/output function to the sum calculated in the previous step 12.5d); 12.5f) where the output of each node calculated in step 12.5e) represents the neural network output, displaying at least one node output as an estimated physiological parameter, or 12.5g) where the output of each node calculated in step 12.5e) represents the output of at least one hidden layer node, passing at least one output from outputs calculated in 12.5e) as input to any subsequent layer of nodes in the neural network.
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Specification