Human uterine tissue plasminogen activator produced by recombinant DNA

  • US 5,344,773 A
  • Filed: 10/01/1985
  • Issued: 09/06/1994
  • Est. Priority Date: 10/01/1984
  • Status: Expired due to Term
First Claim
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1. A recombinant DNA molecule which encodes human tissue plasminogen activator (TPA) and which differs from a naturally occurring DNA molecule encoding naturally occurring human TPA in that, in place of at least one of the Asn codons in the three DNA sequences which encode an Asn-X-(Ser or Thr) signal for N-linked glycosylation in said naturally occurring human TPA corresponding to amino acids 114-116, 181-184, and 445-447 of FIG. 1A-C hereof, there is substituted a Gln codon.

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