Advanced signal processing methodology for the detection, localization and quantification of acute myocardial ischemia

• US 5,365,426 A
• Filed: 09/21/1990
• Issued: 11/15/1994
• Est. Priority Date: 03/13/1987
• Status: Expired due to Fees

• Current Assignee: University of Maryland
• Original Assignee: University of Maryland
• Inventors: Nikias, Chrysostomos L., Siegel, John H.
• Primary Examiner(s): Weinhardt, Robert A.
• Assistant Examiner(s): CHUNG TRANS, XUONG MY
• Application Number:
  US07/586,108
• Time in Patent Office: 1,516 Days
• Field of Search: 364/413.06, 128/702, 128/703, 128/902
• US Class Current: 600/509
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/7246 using correlation, e.g. template matching or determination of similarity
• CPC Class Codes: Y10S 128/92 Computer assisted medical diagnostics

Abstract

Monopolar ECG signals are converted into the multichannel spectrum and autocorrelation domains, and different decision variables are identified from the autospectra. Statistically validated threshold levels are used for comparison with the decision variables to determine the probability of normal and ischemic conditions.

Claims

1. A method of detecting myocardial ischemia from a time-domain ECG signal X(n);

n=0,1, . . . , N, where N is an integer, comprising the steps of;

providing an ECG sensor;

detecting said ECG signal from said ECG sensor;

generating a decision variable from said ECG signal;

comparing said decision variable to a histogram of previously obtained sensor signal data to obtain a myocardial ischemia quantification index corresponding to a probability of ischemia; and

comparing said quantification index to a selected value to determine the presence of myocardial ischemia.

2. A method as defined in claim 1, wherein said generating step comprises converting said ECG signal to the spectrum domain and determining the peak frequency of the converted signal as said variable.

3. A method of detecting myocardial ischemia from a time-domain ECG signal X(n);

n=0,1, . . . , N, where N is an integer, comprising the steps of;

providing an ECG sensor;

detecting said ECG signal from said ECG sensor;

generating a plurality of decision variables from said ECG signal;

comparing said decision variables to at least one histogram of previously obtained sensor signal data to obtain at least one myocardial ischemia quantification index corresponding to a quantification probability of ischemia based on said comparison results; and

comparing said quantification index to a selected value to determine the presence of myocardial ischemia.

4. A method of detecting the existence of muscle dysfunction from a unipolar signal X(n);

n=0,1 . . ., N, representing activation of said muscle, where N is an integer, said method comprising the steps of;

providing an ECG sensor;

detecting said unipolar signal from said muscle activation signal sensor;

generating a decision variable from said unipolar signal;

comparing said decision variable to a threshold value of said decision variable to obtain a muscular dysfunction quantification index corresponding to a quantification probability of the existence of muscle dysfunction; and

comparing said quantification index to a selected value to determine the presence of muscle dysfunction.

5. A method as defined in claim 4, further comprising determining a degree of said dysfunction based on the comparison of said quantification index to said value.

6. A method as defined in claim 5, wherein said muscle dysfunction is myocardial ischemia.

7. A method as defined in claim 4, wherein said muscle dysfunction is myocardial ischemia.

8. A method as defined in claim 7, wherein said histogram has a non-Gaussian distribution.

9. A method of detecting myocardial ischemia from a time-domain ECG signal X(n);

n=0,1, . . . , N, where N is an integer, comprising the steps of;

providing an ECG sensor;

detecting said ECG signal from an ECG sensor;

generating a decision variable from said ECG signal;

generating a histogram from a plurality of preliminary ECG signals corresponding to both normal and ischemic conditions;

comparing said decision variable to said histogram to obtain a myocardial ischemia quantification index corresponding to a quantification probability of ischemia; and

comparing said quantification index to a selected value to determine the presence of myocardial ischemia.

10. A method of detecting the existence of muscle dysfunction from a unipolar signal X(n);

n=0,1, . . . , N, representing activation of said muscle, where N is an integer, said method comprising the steps of;

providing an ECG sensor;

detecting said unipolar signal from said muscle activation sensor;

generating a histogram from a plurality of preliminary unipolar signals corresponding to both normal and dysfunctional conditions;

generating a decision variable from said unipolar signal;

comparing said decision variable to said histogram to obtain a muscular dysfunction quantification index corresponding to a quantification probability of the existence of muscular dysfunction; and

comparing said quantification index to a selected value to determine the existence of muscle dysfunction.

11. A method of detecting myocardial ischemia from a time-domain ECG signal X(n);

n=0,1, . . . , N, where N is an integer, comprising the steps of;

providing an ECG sensor;

detecting said ECG signal from an ECG sensor;

generating a decision variable from said ECG signal;

selecting a threshold value for said decision variable corresponding to a probability of correctly detecting myocardial ischemia when myocardial ischemia is present;

comparing said decision variable to said threshold value of said decision variable to obtain comparison results; and

determining a myocardial ischemia quantification index corresponding to a quantification probability of ischemia based on said comparison results.

12. A method as defined in claim 11, wherein said step of selecting a threshold value comprises selecting said threshold value in accordance with a histogram of previous values of said decision variable.

13. A method of detecting myocardial ischemia from a time-domain ECG signal X(n);

n=0,1, . . . , N, where N is an integer, comprising the steps of;

providing an ECG sensor;

detecting said ECG signal from said ECG sensor;

generating a plurality of decision variables from said ECG signal;

combining said decision variables to form a combined decision variable in a multivariate probability space;

comparing said combined decision variable to a histogram of a plurality of combined decision variables generated from previously obtained sensor signal data to obtain a myocardial ischemia quantification index corresponding to a quantification probability of ischemia; and

comparing said quantification index to a selected value to determine the existence of myocardial ischemia.

14. A method of detecting the existence of muscle dysfunction from a unipolar signal X(n);

n=0,1, . . . , N, representing activation of said muscle, where N is an integer, said method comprising the steps of;

providing a muscle activation signal sensor;

detecting said unipolar signal from said muscle activation sensor;

generating a decision variable from said unipolar signal;

selecting a threshold value for said decision variable corresponding to a probability of correctly detecting myocardial ischemia when myocardial ischemia is present;

comparing said decision variable to said threshold value of said decision variable to obtain comparison results; and

determining a muscular dysfunction quantification index corresponding to a quantification probability of the existence of muscle dysfunction based on said comparison results.