System for monitoring and controlling blood and tissue constituent levels

• US 5,368,028 A
• Filed: 06/16/1993
• Issued: 11/29/1994
• Est. Priority Date: 08/11/1989
• Status: Expired due to Term

• Current Assignee: Cb-Carmel Biotechnology Limited
• Original Assignee: Cb-Carmel Biotechnology Limited
• Inventors: Palti, Yoram
• Primary Examiner(s): Cohen, Lee S.
• Application Number:
  US08/077,893
• Time in Patent Office: 531 Days
• Field of Search: 128/635, 604/31, 604/50, 604/66, 604/67, 204/403, 204/415
• US Class Current: 600/345
• CPC Class Codes: A61B 5/0017 transmitting optical signals transmission by light H04B10/00
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/4839 combined with drug delivery

Abstract

Systems are disclosed which utilize implanted chemo-sensitive living cells to monitor tissue or blood concentration levels of chemicals. The implanted cells produce a detectable electrical, optical or chemical signal in response to changes in concentration in surrounding medium. The signal is then detected and interpreted to give a reading indicative of blood concentration levels. Capsules containing chemo-sensitive cells and electrodes for detecting electrical activity are also disclosed. Methods of monitoring the concentration are also described utilizing the systems and capsules disclosed.

Claims

1. A system for monitoring the concentration of a chemical in a patient'"'"'s blood, body or tissues, said system comprising:

implantable living animal cells that are sensitive to said chemical, said animal cells being capable of producing an electrical, optical, or chemical signal in response to the chemical concentration in the medium surrounding said cells in the patient; and

means for detecting said electrical, optical, or chemical signal.

2. The system of claim 1 wherein the animal cells are sensitive to the concentration of a chemical having a biological response in the patient'"'"'s blood, body or tissues.

3. The system of claim 1 wherein said chemical is a hormone.

4. The system of claim 1 wherein said signal is an electrical signal.

5. The system of claim 4 wherein said cells are contained in a capsule and wherein the means for detecting said electrical, optical, or chemical signal comprises collecting means in said capsule for collecting said electrical signal from said cells.

6. The system of claim 5 wherein said collecting means are metal electrodes in contact with said cells such that said signal can be measured as a potential difference between said electrodes.

7. The system of claim 1 wherein said signal is optical.

8. The system of claim 7 wherein said signal results from changes in the optical characteristics of said cells.

9. The system of claim 8 wherein said optical characteristics are changed by dyes in or on the membranes of said cells that are affected by changes in the membrane potential of said membranes.

10. The system of claim 8 wherein the means for detecting said optical signal comprises an implantable optical sensing device positioned with respect to said cells so as to detect and process said signal for transmission.

11. The system of claim 10 wherein the means for detecting said optical signal further comprises transmission means connected to said implantable optical sensing device for transmitting said processed signal through a body surface.

12. The system of claim 1 wherein the means for detecting said electrical, optical or chemical signal comprises sensor means for detecting said signal through a patient'"'"'s body surface and for correlating said signal to said chemical concentration.

13. The system of claim 12 wherein said sensor means comprises:

detector means for detecting said signal;

processor means connected to said detector means for correlating said signal to said chemical concentration; and

output means connected to said processor means for reporting said chemical concentration.

14. The system of claim 1 wherein said cells are selected from the group consisting of beta cells, alpha cells, taste cells, and combinations thereof.

15. The system of claim 14 wherein said cells are beta cells.

16. A method of monitoring the concentration of a chemical in a patient'"'"'s blood, body or tissues, said method comprising:

implanting into said patient chemical sensitive living animal cells which are sensitive to the concentration of said chemical and capable of producing an electrical, optical, or chemical signal in response to said concentration of said chemical in the medium surrounding said cells in the patient;

detecting said signal; and

correlating said signal with said chemical concentration.

17. The method of claim 16 wherein the animal cells are sensitive to the concentration of a chemical having a biological response in the patient'"'"'s blood, body or tissue.

18. The method of claim 16 wherein said chemical is a hormone.

19. The method of claim 16 wherein said signal is detected through a body surface by an external signal sensor.

20. The method of claim 19 wherein said signal is processed by said sensor and correlated with said corresponding chemical concentration.

21. The method of claim 16 wherein the electrical or optical signal is detected by an implantable signal pickup device that processes said signal for transmission through a body surface.

22. The method of claim 21 wherein said processed signal is transmitted through said body surface and is sensed externally thereof.

23. The method of claim 22 wherein said transmitted signal is correlated with said corresponding chemical concentration.

24. A method of administering a drug or chemical dosage, said method comprising:

implanting into said patient chemical sensitive living animal cells capable of producing a signal in response to the concentration of a chemical in the medium surrounding said cells;

detecting said signal;

correlating said signal with said chemical concentration; and

administering said drug or chemical dosage at a level appropriate to said chemical concentration.

25. The method of claim 24 wherein said chemical is a hormone.

26. The method of claim 24 wherein said dosage is administered by an implanted drug or chemical pump.