Pharmaceutical storage and mixing syringe having high pressure assisted discharge

• US 5,395,326 A
• Filed: 10/20/1993
• Issued: 03/07/1995
• Est. Priority Date: 10/20/1993
• Status: Expired due to Fees

• Current Assignee: Habley Medical Technology Corporation
• Original Assignee: Habley Medical Technology Corporation
• Inventors: Foster, Clark B., Smedley, William H., Haber, Terry M.
• Primary Examiner(s): Yasko, John D.
• Assistant Examiner(s): CERMAK, ADAM
• Application Number:
  US08/140,288
• Time in Patent Office: 503 Days
• Field of Search: 604/82, 604/85, 604/89, 604/90, 604/187, 604/191, 604/219, 604/221, 604/222, 604/228, 604/230, 604/236, 604/237, 604/207, 604/416, 604/56
• US Class Current: 604/90
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/31513 Piston constructions to improve sealing or sliding

Abstract

A hand held syringe has a stationary handle and a moving handle to enable both stored and transported pharmaceuticals to be mixed and injecting the mixed pharmaceuticals under high pressure immediately after mixing through a long needle to a site interior of the body. The syringe is provided for squeeze grip at the stationary and moving handles between fingers and palm and includes a jell storage chamber side-by-side with a diluent storage chamber. Upon initial compression of the handles towards one another against a spring bias, the diluent discharges to the jell mix chamber along a one way path. At the same time, a handle actuated piston with loosely fitting O-ring in the jell mix chamber moves through the jell and introduced diluent effecting mixing movement by allowing the jell and diluent to flow between the piston and jell chamber sidewalls. Flow occurs from the jell chamber by the piston to an expansible chamber delimited by a floating seal. When injection is desired, the syringe is fully expanded against the spring bias and an O-ring on the reciprocating piston is tightened to radially dilate the O-ring to effect sealed wiping of the jell chamber. When full dilation of the O-ring has occurred, the long needle replaces a sealing plug at the distal end of the jell chamber of the syringe and injection occurs under the full squeeze force developed by the digits against the human palm.

Claims

1. A hand held pharmaceutical storage and mixing syringe having high pressure assisted discharge comprising:

first and second relatively moveable handles constructed for movement relative to one another;

a jell storage chamber having a dispensing opening and parallel sidewalls affixed to said first handle for coaction with a moving jell storage chamber piston;

a diluent storage chamber having an outlet at one end with parallel sidewalls and a diluent displacing piston;

means for defining a one way fluid flow path from said diluent storage chamber outlet to said jell storage chamber;

means for moving said diluent displacing piston toward said diluent outlet connected for actuation by relative movement between said handles to expel diluent from said diluent storage chamber to said jell storage chamber;

a moveable jell storage chamber piston affixed to said second handle having a perimeter for movement along the walls of said jell storage chamber responsive to movement between said handles,

means for providing said jell storage chamber piston with an expansible perimeter, said means providing to said piston a first normally contracted perimeter for causing fluid within said jell storage chamber to flow between the sides of said jell storage chamber and said piston to effect mixing of the contents within said jell storage chamber and a second expanded disposition for expelling the contents of said jell storage chamber under pressure;

means for containing mixed diluent and jell flowing by said piston during mixing movement of said piston in said jell storage chamber;

a dispensing passageway from said jell chamber, said dispensing passageway having a removable seal for permitting dispensing of the contents of said jell storage chamber upon seal removal; and

,

means for expanding the perimeter of said piston whereby when said handles are moved relative to one another expulsion of the contents of said jell chamber occurs.

2. A hand held pharmaceutical storage and mixing syringe according to claim 1 and wherein:

one of said relatively moving handles is configured for placement against the palm of a human hand and the other of said relatively moving handles is configured for placement against the combined digits of a human hand.

3. A hand held pharmaceutical storage and mixing syringe according to claim 1 and wherein:

said means for defining said one way fluid flow path includes first and second rubber members confronted one to another, said members as confronted defining a path from said diluent storage chamber to said jell storage chamber.

4. A hand held pharmaceutical storage and mixing syringe according to claim 1 and wherein said means for providing said jell storage chamber piston with an expansible perimeter includes:

an expansible O-ring having a normal diameter corresponding to said first normally contracted perimeter;

means for dilating said jell storage chamber O-ring connected to said piston, said means for dilating said O-ring between said first normally contracted perimeter to said second and expanded disposition for expelling said contents of said jell storage chamber.

5. A hand held pharmaceutical storage and mixing syringe according to claim 4 and wherein:

said means for dilating said O-ring includes paired flanges with said O-ring therebetween, said flanges having a V-shaped section for receiving said O-ring therebetween; and

,

means for urging said flanges towards one another whereby said flanges when urged together expand said O-ring by dilating said O-ring into contact with the walls of said jell storage chamber.

6. A hand held pharmaceutical storage and mixing syringe according to claim 1 and wherein:

said means for containing mixed diluent and jell includes a floating seal in said jell storage chamber, said floating seal enabling movement of said jell storage chamber piston along said jell storage chamber between an end of said jell storage chamber and said floating seal.

7. A hand held pharmaceutical storage and mixing syringe according to claim 6 and further including:

a rod communicated to said second handle and extending into said jell storage chamber; and

,

said floating seal moves along said rod at an inner perimeter of said seal and along the sidewalls of said chamber at an outer perimeter of said seal.

8. A hand held pharmaceutical storage and mixing syringe according to claim 1 and wherein:

said removable seal on said dispensing passageway defines an aperture for mounting a needle when said seal is removed.

9. A hand held pharmaceutical storage and mixing syringe according to claim 1 and further including a rod;

said moveable jell storage chamber piston connected to said handle by said rod, said rod extending into said jell storage chamber;

said rod including a first relatively moveable portion and a second relatively moveable portion;

a first flange attached to one of said relatively moveable portions;

a second flange attached to said other relative moveable portion; and

,

said means for providing said jell storage chamber with an expansible perimeter affixed between said flanges, said means for providing said cylinder with an expansible perimeter responsive to movement of said flanges toward one another under force.

10. A hand held pharmaceutical storage and mixing syringe according to claim 9 and wherein:

said means for moving said relatively moveable members of said piston rod together includes a threaded member threaded to one of said piston rod portions and bearing on the other of said piston rod portions.

11. A method for hand held pharmaceutical storage, mixing and syringe injection with high pressure assisted discharge comprising:

providing first and second relatively moving actuators for relative movement to one another;

providing a jell storage chamber having a dispensing opening and parallel sidewalls affixed to said first actuator for coaction with a moving jell storage chamber piston;

providing a diluent storage chamber having an outlet at one end with parallel sidewalls for coaction with a diluent displacing piston;

defining a one way fluid flow path from said diluent storage chamber outlet to said jell storage chamber;

displacing said diluent displacing piston toward said diluent outlet to expel diluent from said diluent storage chamber to said jell storage chamber;

providing a moveable jell storage chamber piston affixed to said second actuator having a perimeter for movement along the walls of said jell storage chamber responsive to movement between said actuators;

providing said jell storage chamber piston with an expansible perimeter, including a first normally contracted perimeter for causing fluid within said chamber to flow between the sides of said jell storage chamber and said piston to effect mixing of the contents within said jell storage chamber and a second expanded disposition for expelling the contents of said jell storage chamber under pressure;

containing mixed diluent and jell flowing by said piston during mixing movement of said piston in said jell storage chamber;

providing a dispensing passageway from said jell chamber including, said dispensing passageway having a removable seal for permitting dispensing of the contents of said jell storage chamber upon seal removal;

moving said actuators towards and away from one another with said piston having said perimeter in said normal contracted state to mix said diluent and jell;

expanding the perimeter of said piston;

removing said seal from said dispensing passageway; and

,

moving said actuators relative to one another until expulsion of the contents of said jell chamber occurs.

12. A method for hand held pharmaceutical storage, mixing and syringe injection with high pressure assisted discharge according to claim 11 and including the steps of:

placing one of said relatively moving actuators against the palm of a human hand and placing the other of said relatively moving actuators against the combined digits of a human hand.

13. A method for hand held pharmaceutical storage, mixing and syringe injection with high pressure assisted discharge according to claim 11 and including the steps of:

placing a needle to said seal of said dispensing passageway after said moving said actuators step.

14. A hand held pharmaceutical storage and mixing syringe having high pressure assisted discharge comprising:

first and second relatively moving actuators for relative movement to one another;

a first pharmaceutical storage chamber having a dispensing opening and parallel sidewalls affixed to said first actuator for coaction with a first pharmaceutical storage chamber piston;

a second pharmaceutical displacing piston;

a second pharmaceutical storage chamber having an outlet at one end with parallel sidewalls for coaction with said second pharmaceutical displacing piston;

means for defining a one way fluid flow path from said second pharmaceutical storage chamber outlet to said first pharmaceutical storage chamber;

means for moving said second pharmaceutical displacing piston toward said second pharmaceutical outlet connected for actuation by relative movement between said actuators to expel second pharmaceutical from said second pharmaceutical storage chamber to said first pharmaceutical storage chamber;

a moveable first pharmaceutical storage chamber piston affixed to said second actuator having an perimeter for movement along the walls of said first pharmaceutical storage chamber responsive to movement between said actuators;

means for providing said first pharmaceutical storage chamber piston with an expansible perimeter, said means providing to said piston a first normally contracted perimeter for causing fluid within said chamber to flow between the sides of said first pharmaceutical storage chamber and said piston to effect mixing of the contents within said first pharmaceutical storage chamber and a second expanded disposition for expelling the contents of said first pharmaceutical storage chamber under pressure;

means for containing mixed second pharmaceutical and first pharmaceutical flowing by said piston during mixing movement of said piston in said first pharmaceutical storage chamber;

a dispensing passageway from said first pharmaceutical chamber, said dispensing passageway having a removable seal for permitting dispensing of the contents of said first pharmaceutical storage chamber upon seal removal; and

,

means for expanding the perimeter of said piston whereby when said actuators are moved relative to one another expulsion of the contents of said chamber occurs.

17. A hand held pharmaceutical storage and mixing syringe according to claim 14 further comprising said first and second pharmaceuticals and wherein said first pharmaceutical comprises a jell and said second pharmaceutical comprises a diluent.

18. A hand held pharmaceutical storage and mixing syringe according to claim 14 and wherein said first and second relatively moving actuators include a first actuator for fitting to the human palm and a second actuator for grasp by the human digits.

19. A hand held pharmaceutical storage and mixing syringe according to claim 17 and wherein said means for moving said diluent displacing piston includes a sliding member moveable into said piston.

20. A hand held pharmaceutical storage and mixing syringe according to claim 17 and wherein said means for providing said jell storage chamber with an expansible perimeter includes first and second flanges with an O-ring disposed therebetween,

a rod;

a cylinder bed rod;

said first flange connected to said rod;

said second flange connected to said cylinder bed rod, and further including a third member having a thread connection to said rod, bearing on said cylinder bed rod, and biasing said cylinder bed rod toward said first flange.

21. A hand held pharmaceutical storage and mixing syringe according to claim 17 and wherein said means for containing mixed diluent and jell includes a floating member in said first pharmaceutical storage chamber.

22. A hand held pharmaceutical storage and mixing syringe according to claim 17 and wherein said means for providing said storage chamber piston with an expansible perimeter includes a rod including and extending to a first flange, a cylinder including and extending to a second flange, and means for compressing said rod to said cylinder and said means for containing mixed diluent includes a seal, said seal bearing on said cylinder on the inside and on said jell storage chamber on the outside.

23. A hand held pharmaceutical storage and mixing syringe according to claim 14 and wherein said dispensing passageway includes an attachment point for a needle.

15. A hand held pharmaceutical storage and mixing syringe having high pressure assisted discharge comprising:

first and second relatively moving actuators for relative movement to one another;

a first pharmaceutical storage chamber having a dispensing opening and parallel sidewalls affixed to said first actuator for coaction with a moveable first pharmaceutical storage chamber piston;

a first pharmaceutical in said first pharmaceutical storage chamber;

a second pharmaceutical storage chamber having an outlet at one end with parallel sidewalls and a second pharmaceutical displacing piston;

a second pharmaceutical in said second pharmaceutical storage chamber;

means for defining a one way fluid flow path from said second pharmaceutical storage chamber outlet to said first pharmaceutical storage chamber;

means for moving said second pharmaceutical displacing piston toward said second pharmaceutical outlet connected for actuation by relative movement between said actuators to expel second pharmaceutical from said second pharmaceutical storage chamber to said first pharmaceutical storage chamber;

a moveable first pharmaceutical storage chamber piston affixed to said second actuator having an perimeter for movement along the walls of said first pharmaceutical storage chamber responsive to movement between said actuators;

means for providing said first pharmaceutical storage chamber piston with an expansible perimeter, said means providing to said first piston a first normally contracted perimeter for causing fluid within said chamber to flow between the sides of said first pharmaceutical storage chamber and said piston to effect mixing of the contents within said first pharmaceutical storage chamber and a second expanded disposition for expelling the contents of said first pharmaceutical storage chamber under pressure;

means for containing mixed second pharmaceutical and first pharmaceutical flowing by said piston during mixing movement of said piston in said first pharmaceutical storage chamber;

a dispensing passageway from said first pharmaceutical chamber, said dispensing passageway having a removable seal for permitting dispensing of the contents of said first pharmaceutical storage chamber upon seal removal; and

,

means for expanding the perimeter of said piston whereby when said actuators are moved relative to one another expulsion of the contents of said first pharmaceutical chamber occurs.

24. A hand held pharmaceutical storage and mixing syringe according to claim 15 and wherein said first pharmaceutical comprises a jell and said second pharmaceutical comprises a diluent.

25. A hand held pharmaceutical storage and mixing syringe according to claim 24 and wherein said jell includes a cytotoxin and bulking agent and said diluent includes a vasoconstricting agent.

26. A hand held pharmaceutical storage and mixing syringe according to claim 24 and wherein said means for defining a one-way fluid flow path from said diluent storage chamber outlet to said jell storage chamber includes an elastic member defining a channel, said channel beginning at said diluent storage chamber outlet and extending to said jell storage chamber dispensing opening, said member stopping short of said jell storage chamber dispensing opening and being deformable responsive to pressure exerted on said diluent.

16. A method for hand held pharmaceutical storage, mixing and syringe injection with high pressure assisted discharge where the syringe includes:

first and second relatively moving actuators for relative movement to one another;

a first pharmaceutical storage chamber having a dispensing opening and parallel sidewalls affixed to said first actuator for coaction with a moveable first pharmaceutical storage chamber piston;

a second pharmaceutical storage chamber having an outlet at one end with parallel sidewalls and a second pharmaceutical displacing piston;

a one way fluid flow path from said second pharmaceutical storage chamber outlet to said first pharmaceutical storage chamber;

a first pharmaceutical in said first pharmaceutical storage chamber;

a second pharmaceutical in said second pharmaceutical storage chamber;

said method comprising the steps of;

displacing said second pharmaceutical displacing piston toward said second pharmaceutical outlet to expel second pharmaceutical from said second pharmaceutical storage chamber to said first pharmaceutical storage chamber;

providing a moveable first pharmaceutical storage chamber piston affixed to said second actuator having an perimeter for movement along the walls of said first pharmaceutical storage chamber responsive to movement between said actuators;

providing said first pharmaceutical storage chamber piston with an expansible perimeter, said means providing to said piston a first normally contracted perimeter for causing fluid within said chamber to flow between the sides of said first pharmaceutical storage chamber and said piston to effect mixing of the contents within said first pharmaceutical storage chamber and a second expanded disposition for expelling the contents of said first pharmaceutical storage chamber under pressure;

containing mixed second pharmaceutical and first pharmaceutical flowing by said piston during mixing movement of said piston in said first pharmaceutical storage chamber;

providing a dispensing passageway from said first pharmaceutical chamber, said dispensing passageway having a removable seal for permitting dispensing of the contents of said first pharmaceutical storage chamber upon seal removal;

moving said actuators towards and away from one another with said piston having said perimeter in said normal contracted state to mix said second pharmaceutical and first pharmaceutical;

expanding the perimeter of said piston;

removing said seal from said dispensing passageway; and

,

moving said actuators relative to one another until expulsion of the contents of said first pharmaceutical chamber occurs.

27. A method for hand held pharmaceutical storage, mixing and syringe injection according to claim 16 and wherein said first pharmaceutical comprises a jell and said second pharmaceutical comprises a diluent.

28. A method for hand held pharmaceutical storage, mixing and syringe injection according to claim 16 including the steps of:

moving said actuators towards and away from another to tactilely detect decreased resistance of said movement indicating complete mixing.

29. A method for hand held pharmaceutical storage, mixing and syringe injection according to claim 27 and including the step of:

providing a needle, and attaching said needle to said dispensing passageway for injection of said mixed diluent and jell.