Cloned genes encoding reverse transcriptase lacking RNase H activity

  • US 5,405,776 A
  • Filed: 01/24/1992
  • Issued: 04/11/1995
  • Est. Priority Date: 01/13/1988
  • Status: Expired due to Term
First Claim
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1. An isolated DNA compound comprising a DNA sequence encoding a polypeptide having DNA polymerase activity and substantially no RNase H activity wherein said polypeptide may be used for the preparation of full length cDNA without significant degradation of the mRNA template during first strand synthesis wherein said DNA compound is derived from an organism selected from the group consisting of a retrovirus, yeast, Neurospora, Drosophila, primates and rodents.

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