Blood pressure monitoring system

• US 5,406,952 A
• Filed: 02/11/1993
• Issued: 04/18/1995
• Est. Priority Date: 02/11/1993
• Status: Expired due to Fees

• Current Assignee: Biosyss Corporation
• Original Assignee: Biosyss Corporation
• Inventors: Moore, J. Erik, Barnes, Jeffrey T.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): NASSER, ROBERT L
• Application Number:
  US08/016,435
• Time in Patent Office: 796 Days
• Field of Search: 128/672, 128/677-687, 128/690, 364/413.03
• US Class Current: 600/485
• CPC Class Codes: A61B 2562/02 Details of sensors specially adapted for in-vivo measurements
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02108 from analysis of pulse wave characteristics

Abstract

A blood pressure instrument and method in which analog blood pressure waveform signals are digitized and stored and used to determine blood pressure parameters to make physiological measurements based upon pattern recognition using information empirically obtained from clinical measurements. In a preferred embodiment, the analog waveform signals are obtained non-invasively using an external wrist-mounted displacement transducer.

Claims

1. A non-invasive blood pressure monitoring systems comprising:

a) a transducer means including a piezoelectric element responsive to displacement of a transfer member located on a body portion adjacent a radial artery wall for detecting displacement of said radial artery wall caused by blood pressure pulses and generating an electrical displacement signal in response thereto;

b) a signal processor means for receiving said displacement signal and converting the displacement signal to an electrical analog blood pressure waveform signal;

c) computer means for extracting blood pressure parameters and physiological measurements from said waveform signal by recognizing certain patterns in the waveform of the waveform signal; and

d) display means for displaying said parameters, measurements and waveform signal, and wherein said computer means calculates a compensated dicrotic notch ratio CDR by determining the product of a dicrotic ratio DR and a filling time component FTC.

2. The system of claim 1 in which the computer means also calculates a beat time ratio BTR which is the ratio of a time spent in systole to a time spent in diastole.

3. The system of claim 2 in which the computer means calculates a beat ratio BMR which is a ratio of a mean value of the waveform signal between a beginning of systole and an occurrence of a dicrotic notch and the occurrence of the dicrotic notch and an end of diastole.

4. The system of claim 3 in which the computer means calculates an RC time constant RCTC which is an experimental factor representing said waveform signal between the occurrence of a peak dicrotic and an end of diastole.

5. The system of claim 4 in which the computer means includes means for calculating a mean arterial blood pressure MAP from the equation:

space="preserve" listing-type="equation">MAP=a CDR.sup.2 +bBTR+cBMR+dRCTC+eFTC+k

6. wherein a, b, c, d, e, &

k are constants empirically determined by clinical evaluation.

8. The method of claim 6 in which another extracted parameter is the beat time ratio BTR which is the ratio of a time spent in systole to a time spent in diastole.

10. The method of claim 8 in which another extracted parameter is an RC time constant RCTC which is an experimental factor representing the waveform signal between the occurrence of a peak dicrotic to an end of diastole.

7. A method of non-invasive blood pressure monitoring comprising the steps of:

a) detecting displacement of a radial artery caused by blood pressure pulses and generating an electrical displacement signal in response thereto using a piezoelectric sensor having a displacement transfer member;

b) converting the displacement signal to an analog blood pressure waveform signal; and

c) extracting blood pressure parameters and physiological measurements from said waveform signal by recognizing predetermined patterns in the waveform based upon empirical data obtained from clinical studies and wherein one such extracted parameter is a compensated dicrotic notch ratio CDR which is determined by calculating the product of a dicrotic notch ratio DR and a fill time component FTC.

9. The method of claim 7 in which another extracted parameter is a beat mean ratio BMR which is the ratio of a mean value of the waveform signal between a beginning of systole and an occurrence of a dicrotic notch and the occurrence of the dicrotic notch and an end of diastole.

11. The method of claim 9 in which a mean arterial blood pressure MAP is calculated from the equation:

space="preserve" listing-type="equation">MAP=a CDR.sup.2 +bBTR+cBMR+dRCTC+eFTC+k

wherein a, b, c, d, e, &

k are constants empirically determined by clinical evaluation.

13. The system of claim 11 in which the computer means calculates a beat time ration BTR which is the ratio of a time spent in systole to a time spent in diastole.

15. The system of claim 13 in which the computer means calculates an RC time constant RCTC which is an experimental factor representing the waveform signal between the occurrence of a peak dicrotic and the end of diastole.

12. A blood pressure monitoring system comprising:

a) means for external application to a living body including a piezoelectric element responsive to displacement of a transfer member contacting a body portion adjacent a radial artery wall for generating an electrical digital blood pressure waveform signal in response to displacements of said radial artery wall caused by fluctuations in instantaneous blood pressure within the body;

b) computer means for extracting blood pressure parameters and physiological measurements from said digital signal and measuring the height of the waveform signal and recognizing certain patterns in the waveform of the waveform signal; and

c) display means for displaying said parameters, measurements and waveform signal; and

wherein the computer means calculates a beat time ratio BTR which is the ratio of a time spent in systole to a time spent in diastole.

14. The system of claim 12 in which the computer calculates a beat ratio BMR which is a ratio of a mean value of the waveform signal between a beginning of systole and an occurrence of a dicrotic notch and the occurrence of the dicrotic notch and an end of diastole.

16. The system of claim 14 in which the computer means includes means for calculating a mean arterial blood pressure MAP from the equation:

space="preserve" listing-type="equation">MAP=a CDR.sup.2 +bBTR+cBMR+dRCTC+eFTC+k

wherein a, b, c, d, e, &

k are constants empirically determined by clinical evaluation.

18. The method of claim 16 in which an extracted parameter is a beat time ratio BTR which is the ratio of a time spent in systole to a time spent in diastole.

20. The method of claim 18 in which an extracted parameter is an RC time constant RCTC which is an experimental factor representing the waveform signal between an occurrence of a peak dicrotic to the end of diastole.

17. A method of blood pressure monitoring comprising the steps of:

a) detecting displacement of a radial artery wall caused by blood pressure pulses and generating a displacement signal using a piezoelectric sensor having a displacement transfer member;

b) generating an analog blood pressure waveform signal from said displacement signal;

c) converting the analog waveform signal to a digital signal;

d) extracting blood pressure parameters and physiological measurements from said digital signal by recognizing predetermined patterns in the waveform based upon empirical data obtained from clinical studies and in which an extracted blood pressure parameter is a compensated dicrotic notch ratio CDR which is determined by calculating the product of a dicrotic ratio DR and a fill time component FTC.

19. The method of claim 17 in which an extracted parameter is a beat mean ratio BMR which is the ratio of a mean value of the waveform signal between a beginning of systole and an occurrence of a dicrotic notch and the occurrence of the dicrotic notch and an end of diastole.

21. The method of claim 19 in which a mean arterial blood pressure MAP is calculated from the equation:

space="preserve" listing-type="equation">MAP=a CDR.sup.2 +bBTR+cBMR+dRCTC+eFTC+k

wherein a, b, c, d, e, &

k are constants empirically determined by clinical evaluation.

23. The system of claim 21 in which the computer means includes a means for calculating a mean arterial blood pressure MAP from the equation:

space="preserve" listing-type="equation">MAP=a CDR.sup.2 +bBTR+cBMR+dRCTC+eFTC+k

wherein a, b, c, d, e, &

k are constants empirically determined by clinical evaluation.

22. A non-invasive blood pressure sensing system comprising:

a) a transducer comprised of a piezoceramic element having a housing and attachable to the wrist of a patient by a disposable and removable adhesive, the element being responsive to displacement of a transfer member disposed adjacent a radial artery for detecting displacement of the radial artery caused by blood pressure pulses and generating an electrical displacement signal in response thereto;

b) a signal processor means for receiving said displacement signal and converting the displacement signal to an electrical blood pressure waveform signal;

c) computer means for receiving the blood pressure waveform signal and extracting blood pressure parameters and physiological measurements from said waveform signal by recognizing certain patterns in the waveform of the waveform signal and wherein said parameters include the following;

a compensated dicrotic notch ratio CDR, a beat time ratio BTR, a beat mean ratio BMR, a RC time constant RCTC; and

d) display means for displaying said parameters, measurements and waveform signal.