Multi-sensor rate-responsive pacemaker and method of operating same

• US 5,423,869 A
• Filed: 01/21/1993
• Issued: 06/13/1995
• Est. Priority Date: 01/21/1993
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Poore, John W., Medlin, Roy B.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US08/006,906
• Time in Patent Office: 873 Days
• Field of Search: 607/9, 607/2, 607/17, 607/18, 607/19, 607/22
• US Class Current: 607/18
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

A rate-response pacemaker includes a plurality of sensors that each sense a physiologic-related parameter suggestive of the physiological needs of a patient, and hence indicative of the pacing rate at which the rate-responsive pacemaker should provide pacing pulses on demand. The pacemaker includes appropriate selection circuitry for selecting which of the sensor parameters or weighted combinations thereof, should be used as the sensor indicated rate (SIR) signal to control the pacing rate of the pacemaker at any given time. In a preferred embodiment, a maximum sensor rate signal (MR_i) is computed for each sensor, and a maximum sensor rate (MSR) signal is defined for the pacemaker, and the SIR signal is selected as the lesser of: (i) the MSR signal; (ii) the largest of the sensed sensor parameters; or (iii) the respective MR_i signals.

Claims

1. An implantable rate-responsive pacemaker comprising:

a plurality of sensors, each sensor being adapted to sense a physiologic-related parameter of a patient and to generate a sensor signal indicative of such sensed physiologic-related parameter;

a sense amplifier that senses natural contractions of the patient'"'"'s heart;

a pulse generator that generates stimulation pulses responsive to a pacing signal, each stimulation pulse having a pacing energy sufficient to cause a contraction of a preselected chamber of the patient'"'"'s heart;

timing circuitry that defines an escape time interval;

control logic circuitry coupled to said sense amplifier, and said timing circuitry that starts said escape time interval at the beginning of a sensed or paced cardiac cycle, and said control logic circuitry further coupled to said pulse generator generates said pacing signal at the end of said escape time interval unless a natural contraction of the patient'"'"'s heart is sensed by the sense amplifier prior to the end of the escape interval, in which case the escape time interval is restarted and no pacing signal is generated;

processing means coupled to said timing circuitry and said plurality of sensors for generating a sensor indicated rate (SIR) signal comprising selection means for respectively comparing each of said plurality of sensor signals against a predetermined threshold signal, and for selecting the smallest of said sensor signal or said predetermined threshold signal as a potential sensor indicated rate (PSIR) signal, thereby generating a plurality of PSIR signals; and

for selecting said SIR signal as either of the largest and smallest of said plurality of PSIR signals,said SIR signal being used by said timing means to define the duration of said escape time interval.

2. The rate-responsive pacemaker, as set forth in claim 1, wherein said plurality of sensors comprise:

an oxygen saturation sensor for sensing the oxygen saturation level of the patient'"'"'s blood;

and an activity sensor for sensing the physical activity of the patient.

3. The rate-responsive pacemaker, as set forth in claim 2, wherein said pacemaker has a base rate (BR) and a maximum sensor rate (MSR) programmed therein for use by said processing means, and wherein said oxygen saturation sensor generates an oxygen saturation indicated rate (OIR) signal, and said activity sensor generates an activity indicated rate (AIR) signal;

and wherein said processing means generates a maximum oxygen saturation indicated rate (MOR) signal that comprises the AIR signal plus n, where n is an integer greater than 20, and a maximum activity indicated rate (MAR) signal equal to;

space="preserve" listing-type="equation">MAR=OIR+m[(MSR-OIR)/(MSR-BR)],

where m is also an integer greater than 20; and

wherein said sensor indicated rate (SIR) signal is equal to the minimum of;

(1) said MSR signal, (2) the maximum of said OIR or AIR signals, (3) said MOR signal, or (4) said MAR signal.

4. An implantable rate-responsive pacemaker comprising:

a plurality of sensors, each being adapted to sense a physiologic-related parameter of a patient and to generate a sensor signal indicative of such sensed physiologic-related parameter;

a sense amplifier that senses natural contractions of the patient'"'"'s heart;

a pulse generator that generates stimulation pulses responsive to a pacing signal, each stimulation pulse having a pacing energy sufficient to cause contraction of a selected chamber of the patient'"'"'s heart;

timing circuitry that defines an escape time interval;

control logic circuitry coupled to said sense amplifier, and said timing circuitry that starts said escape time interval at the beginning of a sensed or paced cardiac cycle, and said control logic circuitry further coupled to said pulse generator generates said pacing signal at the end of said escape time interval unless a natural contraction of the patient'"'"'s heart is sensed by the sense amplifier prior to the end of the escape interval, in which case the escape time interval is restarted and no pacing signal is generated;

processing means coupled to said timing circuitry and said plurality of sensors for generating a sensor indicated rate (SIR) signal, as a prescribed weighted combination of the plurality of sensor signals, with the amount of weight given one sensor signal at any given time varying as a function of which sensor signal best typifies the physiologic need of the patient at that time, said SIR signal being used by said timing means to define the duration of said escape time interval; and

said processing means further comprises;

signal conditioning means for conditioning a predetermined group of said sensor signals to produce at least one conditioned sensor signal; and

selection means for selecting one of said plurality of sensor signals, said at least one conditioned sensor signal, or one of a plurality of reference threshold signals, as a potential sensor indicated rate (PSIR) signal, depending upon which is smallest, and for selecting said PSIR signal as the SIR signal whenever it satisfies a specified criteria.

5. The rate-responsive pacemaker, as set forth in claim 4, wherein said selection means selects a plurality of PSIR signals, and wherein the largest of said PSIR signals is selected as the SIR signal.

6. An implantable rate-responsive pacing system comprising:

a plurality of sensors, each being adapted to sense a respective physiologic-related parameter of a patient and to generate a physiological signal indicative of such sensed physiologic-related parameter;

a sense amplifier that senses natural contractions of the patient'"'"'s heart;

a pulse generator that generates stimulation pulses responsive to a pacing signal and delivers such stimulation pulses to the patient'"'"'s heart;

control/timing means for defining an escape interval and starting said escape interval at the beginning of a sensed or paced cardiac cycle, and generating said pacing signal at the end of said escape interval unless a natural contraction of the patient'"'"'s heart is sensed by the sense amplifier prior to the conclusion of the escape interval, in which case the escape interval is restarted and no pacing signal is generated;

telemetry means for programming said pacemaker with a desired base rate (BR) signal and a maximum sensor rate (MSR) signal; and

sensor processing means coupled to said control/timing means for generating a sensor indicated rate (SIR) signal, said SIR signal being used by said control/timing means to define the duration of said escape interval, said SIR signal comprising the lesser of;

(a) the MSR signal;

or (b) the largest of said plurality of physiological signals;

whereby said rate-responsive pacing system generates stimulation pulses on demand at a rate determined by the SIR signal.

7. The rate-responsive pacing system, as set forth in claim 6, wherein said sensor processing means is for further computing a first maximum sensor rate (MR₁) for a first sensor of said plurality of sensors and a second maximum sensor rate (MR₂) for a second of said plurality of physiological sensors;

and wherein said SIR signal comprises the lesser of;

(a) the MSR signal;

(b) the largest of said plurality of rate signals;

(c) the MR₁ signal;

or (d) the MR₂ signal.

8. The rate-responsive pacing system of claim 7, wherein said MR₁ signal comprises the sum of the physiological signal generated by the second sensor and a fixed integer value n.

9. The rate-responsive pacing system of claim 7, wherein said MR₂ signal comprises the sum of the physiological signal generated by the first physiological sensor and a variable y, said variable y comprising a function of the difference between the physiological signal of the first physiological sensor and the MSR signal.

10. The rate-responsive pacing system of claim 9, wherein the variable y comprises

11. The rate-responsive pacing system of claim 10, wherein said first physiological sensor comprises a sensor that senses the oxygen saturation content of the patient'"'"'s blood, and said second physiological sensor comprises a sensor that senses the physical activity of the patient.

12. The rate-responsive pacing system of claim 11, wherein m is equal to 30.

13. A method of operating an implantable rate-responsive pacemaker that utilizes a plurality of rate sensors, each of said rate sensors generating a respective rate signal that indicates a sensed physiologic-related parameter of a patient, said method comprising the steps of:

(a) processing said plurality of rate signals to determine a sensor indicated rate (SIR) signal, said processing including;

(1) defining a maximum sensor rate (MSR) signal;

(2) selecting the SIR signal as the lesser of;

(i) the MSR signal, or (ii) the largest of said plurality of rate signals;

(b) using said SIR signal to define an escape interval for said implantable rate-responsive pacemaker;

(c) sensing natural cardiac activity of the patient;

(d) starting said escape interval upon sensing natural cardiac activity; and

(e) generating a stimulation pulse at the end of said escape interval and restarting said escape interval unless a natural contraction of the patient'"'"'s heart is sensed prior to the end of the escape interval, in which case the escape interval is immediately restarted and no stimulation signal is generated;

whereby said rate-responsive pacemaker generates stimulation pulses on demand at a rate determined by the SIR signal, said SIR signal resulting from the specified processing of the plurality of rate signals obtained from the plurality of rate sensors.

14. The method of claim 13, wherein step (a) further includes:

computing a first maximum sensor rate (MR₁) for a first sensor of said plurality of sensors and a second maximum sensor rate (MR₂) for a second of said plurality of sensors; and

selecting the SIR signal as the lesser of;

(i) the MSR signal, (ii) the largest of said plurality of rate signals, (iii) the MR₁ signal, or (iv) the MR₂ signal.

15. The method of claim 14, wherein the step of computing the MR₁ signal comprises adding a fixed increment n to the rate signal of the second sensor.

16. The method of claim 14, wherein the step of computing the MR₂ signal comprises adding a variable y to the rate signal of the first sensor.

17. The method of claim 16, wherein the variable y comprises y=m[(MSR-x)/(MSR-BR)], where m is an integer greater than 20, x is the rate signal of the first sensor, and BR is a base rate of the rate-responsive pacemaker.