Production of recombinant erythropoietin

  • US 5,441,868 A
  • Filed: 10/23/1987
  • Issued: 08/15/1995
  • Est. Priority Date: 12/13/1983
  • Status: Expired due to Term
First Claim
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1. A process for the production of a glycosylated erythropoietin polypeptide having the in vivo biological property of causing bone marrow cells to increase production of reticulocytes and red blood cells comprising the steps of:

  • (a) growing, under suitable nutrient conditions, mammalian host cells transformed or transfected with an isolated DNA sequence encoding human erythropoietin; and

    (b) isolating said glycosylated erythropoietin polypeptide therefrom.

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