Topical compositions containing bensoyl peroxide and clindamycin and method of use thereof

  • US 5,466,446 A
  • Filed: 02/16/1994
  • Issued: 11/14/1995
  • Est. Priority Date: 02/16/1994
  • Status: Expired due to Term
First Claim
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1. A topical gel composition for treating skin disorders involving the sebaceous glands and follicles in humans, said composition consisting essentially of an effective amount of a mixture of:

  • (i) at least 4.5% by weight of benzoyl peroxide, and (ii) at least 0.9% by weight of clindamycin, admixed with a topically acceptable pharmaceutical carrier consisting essentially of about 0.04% disodium monolaurel sulfosuccinate, about 2.0% of a carbomer, about 0.1% of disodium ethylene diaminetetraacetic acid, about 0.1% of dimethicone, about 0.25% of hydrated silica, about 0.20% of poloxamer 182 and about 0.31% of sodium hydroxide by weight of said composition, wherein the composition is stable for at least 3 months at ambient temperature.

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