Method and apparatus for arousal detection

• US 5,485,851 A
• Filed: 09/21/1994
• Issued: 01/23/1996
• Est. Priority Date: 09/21/1994
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated MS 301
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Erickson, Donald J.
• Primary Examiner(s): Cohen, Lee S.
• Application Number:
  US08/310,125
• Time in Patent Office: 489 Days
• Field of Search: 128/716, 128/721-723, 128/725, 128/782, 607/42
• US Class Current: 600/529
• CPC Class Codes: A61N 1/3601 of respiratory organs

Abstract

A method and device for detecting arousal from sleep in a patient by monitoring a respiratory effort waveform of the patient. At least one parameter of the waveform that is characteristic of a body movement artifact is monitored and compared with a predetermined limit. This method of arousal detection is particularly useful for treating sleep apnea by bursts of electrical stimulation in response to sensed inspiration since it allows the electrical stimulation to be reduced or stopped promptly as the patient wakes.

Claims

1. A method for detecting arousal from sleep in a patient by the steps of:

(a) sensing a signal characteristic of respiratory effort of the patient;

(b) sampling the sensed signal at a predetermined interval to provide a digitized respiratory effort waveform;

(c) monitoring the digitized signal for at least one parameter of the waveform indicating a body movement artifact; and

(d) comparing at least one value for the parameter with a predetermined limit to determine whether the patient is aroused.

2. The method of claim 1 wherein the parameter for comparison with the predetermined limit is selected from the group consisting of inspiratory rise time, inspiratory time-to-peak, time of inspiratory onset to expiratory offset, inspiratory peak-to-peak time, expiratory peak-to-peak time and breath-to-breath time.

3. The method of claim 2 wherein the parameter is inspiratory rise time and the predetermined limit is less than 220 milliseconds.

4. The method of claim 2 wherein the parameter is inspiratory time-to-peak and the predetermined limit is less than 750 milliseconds.

5. The method of claim 2 wherein the parameter is time of inspiratory onset to expiratory offset and the predetermined limit is less than 1000 milliseconds.

6. The method of claim 2 wherein the parameter is inspiratory peak-to-peak time and the predetermined limit is less than 2 seconds.

7. The method of claim 2 wherein the parameter is expiratory peak-to-peak time and the predetermined limit is less than 2 seconds.

8. The method of claim 2 wherein the parameter is breath-to-breath time and the predetermined limit is less than 2 seconds.

9. The method of claim 1 wherein the predetermined limit is based on a baseline average of values for the parameter.

10. The method of claim 9 wherein the parameter is inspiratory rise time and the inspiratory rise time is less than the baseline minus an amount in the range of about 1000 to 1500 milliseconds.

11. The method of claim 9 wherein the parameter is inspiratory time-to-peak time and the inspiratory time-to-peak time is less than the baseline minus an amount in the range of about 1400 to 2100 milliseconds.

12. The method of claim 9 wherein the parameter is the time of inspiratory onset to expiratory offset and the time of inspiratory onset to expiratory offset is less than the baseline minus an amount in the range of about 2200 to 3300 milliseconds.

13. The method of claim 1 wherein the step of comparing at least one value for the parameter with a predetermined limit includes averaging multiple values for the parameter and comparing the average with the predetermined limit.

14. The method of claim 1 also comprising the step of adjusting the predetermined limit.

15. The method of claim 1 also comprising the steps of:

(a) monitoring a signal from an activity sensor measuring activity of the patient;

(b) comparing the activity sensor signal with a predetermined limit; and

(c) determining whether the patient is aroused by comparisons of both activity sensor signal and parameter value.

16. A method for treatment of a patient by electrical stimulation upon detecting arousal from sleep in the patient by the steps of:

(a) providing electrical stimulation to the patient;

(b) monitoring a respiratory effort waveform of the patient for at least one parameter of the waveform indicating a body movement artifact;

(c) comparing at least one value for the parameter with a predetermined limit to determine whether the patient is aroused; and

(d) adjusting treatment of the patient upon detection of arousal by reducing electrical stimulation applied to the patient upon arousal.

17. A medical device for the detection of arousal from sleep in a patient comprising:

(a) signal sensing means for sensing a signal characteristic of respiratory effort of the patient;

(b) signal sampling means for sampling the sensed signal at a predetermined interval to provide a digitized respiratory effort waveform;

(c) monitoring means for monitoring the digitized signal for at least one parameter of the waveform indicating a body movement artifact; and

(d) comparison means associated with said monitoring means for comparing at least one value for the parameter with a predetermined limit to determine whether the patient is aroused.

18. The medical device of claim 17 wherein the parameter for comparison with the predetermined limit is selected from the group consisting of inspiratory rise time, inspiratory time-to-peak, time of inspiratory onset to expiratory offset, inspiratory peak-to-peak time, expiratory peak-to-peak time and breath-to-breath time.

19. The medical device of claim 18 wherein the parameter is inspiratory rise time and the predetermined limit is less than 220 milliseconds.

20. The medical device of claim 18 wherein the parameter is inspiratory time-to-peak and the predetermined limit is less than 750 milliseconds.

21. The medical device of claim 18 wherein the parameter is time of inspiratory onset to expiratory offset and the predetermined limit is less than 1000 milliseconds.

22. The medical device of claim 18 wherein the parameter is inspiratory peak-to-peak time and the predetermined limit is less than 2 seconds.

23. The medical device of claim 18 wherein the parameter is expiratory peak-to-peak time and the predetermined limit is less than 2 seconds.

24. The medical device of claim 18 wherein the parameter is breath-to-breath time and the predetermined limit is less than 2 seconds.

25. The medical device of claim 17 wherein the predetermined limit is based on a baseline average of values for the parameter.

26. The medical device of claim 25 wherein the parameter is inspiratory rise time and the inspiratory rise time is less than the baseline minus an amount in the range of about 1000 to 1500 milliseconds.

27. The medical device of claim 25 wherein the parameter is inspiratory time-to-peak time and the inspiratory time-to-peak time is less than the baseline minus an amount in the range of about 1400 to 2100 milliseconds.

28. The medical device of claim 25 wherein the parameter is the time of inspiratory onset to expiratory offset and the time of inspiratory onset to expiratory offset is less than the baseline minus an amount in the range of about 2200 to 3300 milliseconds.

29. The medical device of claim 17 also comprising averaging means associated with said monitoring means for averaging multiple values for the parameter and comparing the average with the predetermined limit.

30. The medical device of claim 17 also comprising adjusting means for adjusting the predetermined limit.

31. The medical device of claim 17 also comprising:

(a) an activity sensor;

(b) activity comparison means associated with said activity sensor for comparing a signal from the sensor with a predetermined limit; and

(c) arousal determining means associated with said activity comparison means and said comparison means for determining whether the patient is aroused by comparisons of both activity sensor signal and parameter value.

32. A medical device for treatment of a patient by electrical stimulation upon the detection of arousal from sleep in the patient comprising:

(a) stimulation means for electrical stimulation of the patient;

(b) monitoring means for monitoring a respiratory effort waveform of the patient for at least one parameter of the waveform indicating a body movement artifact;

(c) comparison means associated with said monitoring means for comparing at least one value for the parameter with a predetermined limit to determine whether the patient is aroused; and

(d) treatment adjusting means associated with said stimulation means, monitoring means and comparing means for reducing electrical stimulation to the patient upon detection of arousal.