Crystals of N-(trans-4-isopropylcyclohexycarbonyl)-D-phenylalanine and methods for preparing them

  • US 5,488,150 A
  • Filed: 12/14/1993
  • Issued: 01/30/1996
  • Est. Priority Date: 07/30/1991
  • Status: Expired due to Term
First Claim
Patent Images

1. A method for the production of crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine having at least one of the following properties:

  • (a) a melting point in the range of 136°

    -142°

    C.;

    (b) a powder X-ray diffraction pattern with reflection maxima at 2θ

    of about 8.1°

    , 13.1°

    , 19.6° and

    19.9°

    ;

    comprising dissolving or suspending N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine in a solvent in which it is completely or incompletely soluble at a temperature of at least 10°

    C. and up to the boiling point of the solvent and permitting said crystals to crystallize from or form in said solvent at a temperature of 10°

    C. or in excess thereof.

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